Increased facilitatory connectivity from the pre-SMA to the left dorsal premotor cortex during pseudoword repetition

TY - JOUR

T1 - Increased facilitatory connectivity from the pre-SMA to the left dorsal premotor cortex during pseudoword repetition

AU - Hartwigsen, Gesa

AU - Saur, Dorothee

AU - Price, Cathy J

AU - Baumgärtner, Annette

AU - Ulmer, Stephan

AU - Siebner, Hartwig R

PY - 2013/4/1

Y1 - 2013/4/1

N2 - Previous studies have demonstrated that the repetition of pseudowords engages a network of premotor areas for articulatory planning and articulation. However, it remains unclear how these premotor areas interact and drive one another during speech production. We used fMRI with dynamic causal modeling to investigate effective connectivity between premotor areas during overt repetition of words and pseudowords presented in both the auditory and visual modalities. Regions involved in phonological aspects of language production were identified as those where regional increases in the BOLD signal were common to repetition in both modalities. We thus obtained three seed regions: the bilateral pre-SMA, left dorsal premotor cortex (PMd), and left ventral premotor cortex that were used to test 63 different models of effective connectivity in the premotor network for pseudoword relative to word repetition. The optimal model was identified with Bayesian model selection and reflected a network with driving input to pre-SMA and an increase in facilitatory drive from pre-SMA to PMd during repetition of pseudowords. The task-specific increase in effective connectivity from pre-SMA to left PMd suggests that the pre-SMA plays a supervisory role in the generation and subsequent sequencing of motor plans. Diffusion tensor imaging-based fiber tracking in another group of healthy volunteers showed that the functional connection between both regions is underpinned by a direct cortico-cortical anatomical connection.

AB - Previous studies have demonstrated that the repetition of pseudowords engages a network of premotor areas for articulatory planning and articulation. However, it remains unclear how these premotor areas interact and drive one another during speech production. We used fMRI with dynamic causal modeling to investigate effective connectivity between premotor areas during overt repetition of words and pseudowords presented in both the auditory and visual modalities. Regions involved in phonological aspects of language production were identified as those where regional increases in the BOLD signal were common to repetition in both modalities. We thus obtained three seed regions: the bilateral pre-SMA, left dorsal premotor cortex (PMd), and left ventral premotor cortex that were used to test 63 different models of effective connectivity in the premotor network for pseudoword relative to word repetition. The optimal model was identified with Bayesian model selection and reflected a network with driving input to pre-SMA and an increase in facilitatory drive from pre-SMA to PMd during repetition of pseudowords. The task-specific increase in effective connectivity from pre-SMA to left PMd suggests that the pre-SMA plays a supervisory role in the generation and subsequent sequencing of motor plans. Diffusion tensor imaging-based fiber tracking in another group of healthy volunteers showed that the functional connection between both regions is underpinned by a direct cortico-cortical anatomical connection.

KW - Acoustic Stimulation

KW - Adult

KW - Brain Mapping

KW - Female

KW - Functional Laterality

KW - Humans

KW - Image Processing, Computer-Assisted

KW - Magnetic Resonance Imaging

KW - Male

KW - Models, Psychological

KW - Motor Cortex

KW - Neural Pathways

KW - Oxygen

KW - Photic Stimulation

KW - Reaction Time

KW - Vocabulary

KW - Young Adult

U2 - 10.1162/jocn_a_00342

DO - 10.1162/jocn_a_00342

M3 - SCORING: Journal article

C2 - 23249347

VL - 25

SP - 580

EP - 594

JO - J COGNITIVE NEUROSCI

JF - J COGNITIVE NEUROSCI

SN - 0898-929X

IS - 4

ER -