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Increased expression of heparanase in symptomatic carotid atherosclerosis.

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Increased expression of heparanase in symptomatic carotid atherosclerosis. / Osterholm, C; Folkersen, L; Lengquist, M; Pontén, F; Renné, Thomas; Li, Jp; Hedin, U.

In: ATHEROSCLEROSIS, Vol. 226, No. 1, 1, 2013, p. 67-73.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Osterholm, C, Folkersen, L, Lengquist, M, Pontén, F, Renné, T, Li, J & Hedin, U 2013, 'Increased expression of heparanase in symptomatic carotid atherosclerosis.', ATHEROSCLEROSIS, vol. 226, no. 1, 1, pp. 67-73. <http://www.ncbi.nlm.nih.gov/pubmed/23137827?dopt=Citation>

APA

Osterholm, C., Folkersen, L., Lengquist, M., Pontén, F., Renné, T., Li, J., & Hedin, U. (2013). Increased expression of heparanase in symptomatic carotid atherosclerosis. ATHEROSCLEROSIS, 226(1), 67-73. [1]. http://www.ncbi.nlm.nih.gov/pubmed/23137827?dopt=Citation

Vancouver

Osterholm C, Folkersen L, Lengquist M, Pontén F, Renné T, Li J et al. Increased expression of heparanase in symptomatic carotid atherosclerosis. ATHEROSCLEROSIS. 2013;226(1):67-73. 1.

Bibtex

@article{f81204e03519424d99b2b7647a9b10f4,
title = "Increased expression of heparanase in symptomatic carotid atherosclerosis.",
abstract = "Proliferation of smooth muscle cells (SMCs) can stabilize atherosclerotic lesions but the molecular mechanisms that regulate this process in humans are largely unknown. We have previously shown that heparan sulfate proteoglycans (HSPGs), such as perlecan, regulate SMC growth in animal models by modulating heparin-binding mitogens. Since perlecan is expressed at low levels in human atherosclerosis, we speculated that the effect of heparan sulfate (HS) in human disease was rather influenced by HS degradation and investigated the expression of heparanase (HPSE) in human carotid endarterectomies.",
keywords = "Adult, Humans, Middle Aged, Gene Expression Regulation, Carotid Artery Diseases/*enzymology/genetics, Glucuronidase/*biosynthesis/genetics, Adult, Humans, Middle Aged, Gene Expression Regulation, Carotid Artery Diseases/*enzymology/genetics, Glucuronidase/*biosynthesis/genetics",
author = "C Osterholm and L Folkersen and M Lengquist and F Pont{\'e}n and Thomas Renn{\'e} and Jp Li and U Hedin",
year = "2013",
language = "English",
volume = "226",
pages = "67--73",
journal = "ATHEROSCLEROSIS",
issn = "0021-9150",
publisher = "Elsevier Ireland Ltd",
number = "1",

}

RIS

TY - JOUR

T1 - Increased expression of heparanase in symptomatic carotid atherosclerosis.

AU - Osterholm, C

AU - Folkersen, L

AU - Lengquist, M

AU - Pontén, F

AU - Renné, Thomas

AU - Li, Jp

AU - Hedin, U

PY - 2013

Y1 - 2013

N2 - Proliferation of smooth muscle cells (SMCs) can stabilize atherosclerotic lesions but the molecular mechanisms that regulate this process in humans are largely unknown. We have previously shown that heparan sulfate proteoglycans (HSPGs), such as perlecan, regulate SMC growth in animal models by modulating heparin-binding mitogens. Since perlecan is expressed at low levels in human atherosclerosis, we speculated that the effect of heparan sulfate (HS) in human disease was rather influenced by HS degradation and investigated the expression of heparanase (HPSE) in human carotid endarterectomies.

AB - Proliferation of smooth muscle cells (SMCs) can stabilize atherosclerotic lesions but the molecular mechanisms that regulate this process in humans are largely unknown. We have previously shown that heparan sulfate proteoglycans (HSPGs), such as perlecan, regulate SMC growth in animal models by modulating heparin-binding mitogens. Since perlecan is expressed at low levels in human atherosclerosis, we speculated that the effect of heparan sulfate (HS) in human disease was rather influenced by HS degradation and investigated the expression of heparanase (HPSE) in human carotid endarterectomies.

KW - Adult

KW - Humans

KW - Middle Aged

KW - Gene Expression Regulation

KW - Carotid Artery Diseases/enzymology/genetics

KW - Glucuronidase/biosynthesis/genetics

KW - Adult

KW - Humans

KW - Middle Aged

KW - Gene Expression Regulation

KW - Carotid Artery Diseases/enzymology/genetics

KW - Glucuronidase/biosynthesis/genetics

M3 - SCORING: Journal article

VL - 226

SP - 67

EP - 73

JO - ATHEROSCLEROSIS

JF - ATHEROSCLEROSIS

SN - 0021-9150

IS - 1

M1 - 1

ER -