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Increased concentrations of C-reactive protein and IL-6 but not IL-18 are independently associated with incident coronary events in middle-aged men and women

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Increased concentrations of C-reactive protein and IL-6 but not IL-18 are independently associated with incident coronary events in middle-aged men and women : results from the MONICA/KORA Augsburg case-cohort study, 1984-2002. / Koenig, Wolfgang; Khuseyinova, Natalie; Baumert, Jens; Thorand, Barbara; Loewel, Hannelore; Chambless, Lloyd; Meisinger, Christa; Schneider, Andrea; Martin, Stephan; Kolb, Hubert; Herder, Christian.

In: ARTERIOSCL THROM VAS, Vol. 26, No. 12, 12.2006, p. 2745-2751.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research

Harvard

Koenig, W, Khuseyinova, N, Baumert, J, Thorand, B, Loewel, H, Chambless, L, Meisinger, C, Schneider, A, Martin, S, Kolb, H & Herder, C 2006, 'Increased concentrations of C-reactive protein and IL-6 but not IL-18 are independently associated with incident coronary events in middle-aged men and women: results from the MONICA/KORA Augsburg case-cohort study, 1984-2002', ARTERIOSCL THROM VAS, vol. 26, no. 12, pp. 2745-2751. https://doi.org/10.1161/01.ATV.0000248096.62495.73

APA

Koenig, W., Khuseyinova, N., Baumert, J., Thorand, B., Loewel, H., Chambless, L., Meisinger, C., Schneider, A., Martin, S., Kolb, H., & Herder, C. (2006). Increased concentrations of C-reactive protein and IL-6 but not IL-18 are independently associated with incident coronary events in middle-aged men and women: results from the MONICA/KORA Augsburg case-cohort study, 1984-2002. ARTERIOSCL THROM VAS, 26(12), 2745-2751. https://doi.org/10.1161/01.ATV.0000248096.62495.73

Vancouver

Koenig W, Khuseyinova N, Baumert J, Thorand B, Loewel H, Chambless L et al. Increased concentrations of C-reactive protein and IL-6 but not IL-18 are independently associated with incident coronary events in middle-aged men and women: results from the MONICA/KORA Augsburg case-cohort study, 1984-2002. ARTERIOSCL THROM VAS. 2006 Dec;26(12):2745-2751. https://doi.org/10.1161/01.ATV.0000248096.62495.73

Bibtex

@article{52dc220db1e44c4fa69ea5698941ea72,
title = "Increased concentrations of C-reactive protein and IL-6 but not IL-18 are independently associated with incident coronary events in middle-aged men and women: results from the MONICA/KORA Augsburg case-cohort study, 1984-2002",
abstract = "OBJECTIVE: We performed a prospective case-cohort study in initially healthy, middle-aged men and women from the MONICA/KORA Augsburg studies conducted between 1984 and 2002 to assess the role of IL-18 in comparison with IL-6 and CRP in the prediction of incident coronary heart disease (CHD).METHODS AND RESULTS: Concentrations of IL-18 were measured in 382 case subjects with incident CHD and 1980 noncases. Mean follow-up was 11 years. Baseline concentrations of IL-18 were slightly higher in cases than in noncases (172.4 [1.0] versus 161.3 [1.0] pg/mL, respectively; P=0.114), but were clearly elevated for C-reactive protein (CRP) and IL-6 in cases compared with noncases. In multivariable analyses, accounting for classical cardiovascular risk factors and inflammatory markers, no statistically significant association was seen between increased concentrations of IL-18 and incident CHD both in men (hazard ratio [HR] and 95% confidence intervals [CIs] comparing extreme tertiles, 1.20; 95% CI, 0.85 to 1.69), and in women (HR, 1.25; 95% CI, 0.67 to 2.34). However, in this population increased concentrations of CRP and IL-6 were found to be independent predictors of future CHD events, even after multivariable adjustment.CONCLUSIONS: Elevated concentrations of CRP and IL-6, but not IL-18, were independently associated with risk of CHD in subjects from an area with moderate absolute risk.",
keywords = "Adult, Age Factors, Aged, C-Reactive Protein/analysis, Case-Control Studies, Coronary Artery Disease/blood, Death, Sudden, Cardiac, Female, Follow-Up Studies, Germany, Humans, Interleukin-18/blood, Interleukin-6/blood, Male, Middle Aged, Multivariate Analysis, Myocardial Infarction/blood, Predictive Value of Tests, Prospective Studies",
author = "Wolfgang Koenig and Natalie Khuseyinova and Jens Baumert and Barbara Thorand and Hannelore Loewel and Lloyd Chambless and Christa Meisinger and Andrea Schneider and Stephan Martin and Hubert Kolb and Christian Herder",
year = "2006",
month = dec,
doi = "10.1161/01.ATV.0000248096.62495.73",
language = "English",
volume = "26",
pages = "2745--2751",
journal = "ARTERIOSCL THROM VAS",
issn = "1079-5642",
publisher = "Lippincott Williams and Wilkins",
number = "12",

}

RIS

TY - JOUR

T1 - Increased concentrations of C-reactive protein and IL-6 but not IL-18 are independently associated with incident coronary events in middle-aged men and women

T2 - results from the MONICA/KORA Augsburg case-cohort study, 1984-2002

AU - Koenig, Wolfgang

AU - Khuseyinova, Natalie

AU - Baumert, Jens

AU - Thorand, Barbara

AU - Loewel, Hannelore

AU - Chambless, Lloyd

AU - Meisinger, Christa

AU - Schneider, Andrea

AU - Martin, Stephan

AU - Kolb, Hubert

AU - Herder, Christian

PY - 2006/12

Y1 - 2006/12

N2 - OBJECTIVE: We performed a prospective case-cohort study in initially healthy, middle-aged men and women from the MONICA/KORA Augsburg studies conducted between 1984 and 2002 to assess the role of IL-18 in comparison with IL-6 and CRP in the prediction of incident coronary heart disease (CHD).METHODS AND RESULTS: Concentrations of IL-18 were measured in 382 case subjects with incident CHD and 1980 noncases. Mean follow-up was 11 years. Baseline concentrations of IL-18 were slightly higher in cases than in noncases (172.4 [1.0] versus 161.3 [1.0] pg/mL, respectively; P=0.114), but were clearly elevated for C-reactive protein (CRP) and IL-6 in cases compared with noncases. In multivariable analyses, accounting for classical cardiovascular risk factors and inflammatory markers, no statistically significant association was seen between increased concentrations of IL-18 and incident CHD both in men (hazard ratio [HR] and 95% confidence intervals [CIs] comparing extreme tertiles, 1.20; 95% CI, 0.85 to 1.69), and in women (HR, 1.25; 95% CI, 0.67 to 2.34). However, in this population increased concentrations of CRP and IL-6 were found to be independent predictors of future CHD events, even after multivariable adjustment.CONCLUSIONS: Elevated concentrations of CRP and IL-6, but not IL-18, were independently associated with risk of CHD in subjects from an area with moderate absolute risk.

AB - OBJECTIVE: We performed a prospective case-cohort study in initially healthy, middle-aged men and women from the MONICA/KORA Augsburg studies conducted between 1984 and 2002 to assess the role of IL-18 in comparison with IL-6 and CRP in the prediction of incident coronary heart disease (CHD).METHODS AND RESULTS: Concentrations of IL-18 were measured in 382 case subjects with incident CHD and 1980 noncases. Mean follow-up was 11 years. Baseline concentrations of IL-18 were slightly higher in cases than in noncases (172.4 [1.0] versus 161.3 [1.0] pg/mL, respectively; P=0.114), but were clearly elevated for C-reactive protein (CRP) and IL-6 in cases compared with noncases. In multivariable analyses, accounting for classical cardiovascular risk factors and inflammatory markers, no statistically significant association was seen between increased concentrations of IL-18 and incident CHD both in men (hazard ratio [HR] and 95% confidence intervals [CIs] comparing extreme tertiles, 1.20; 95% CI, 0.85 to 1.69), and in women (HR, 1.25; 95% CI, 0.67 to 2.34). However, in this population increased concentrations of CRP and IL-6 were found to be independent predictors of future CHD events, even after multivariable adjustment.CONCLUSIONS: Elevated concentrations of CRP and IL-6, but not IL-18, were independently associated with risk of CHD in subjects from an area with moderate absolute risk.

KW - Adult

KW - Age Factors

KW - Aged

KW - C-Reactive Protein/analysis

KW - Case-Control Studies

KW - Coronary Artery Disease/blood

KW - Death, Sudden, Cardiac

KW - Female

KW - Follow-Up Studies

KW - Germany

KW - Humans

KW - Interleukin-18/blood

KW - Interleukin-6/blood

KW - Male

KW - Middle Aged

KW - Multivariate Analysis

KW - Myocardial Infarction/blood

KW - Predictive Value of Tests

KW - Prospective Studies

U2 - 10.1161/01.ATV.0000248096.62495.73

DO - 10.1161/01.ATV.0000248096.62495.73

M3 - SCORING: Journal article

C2 - 17008587

VL - 26

SP - 2745

EP - 2751

JO - ARTERIOSCL THROM VAS

JF - ARTERIOSCL THROM VAS

SN - 1079-5642

IS - 12

ER -