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Increased bone formation and osteosclerosis in mice overexpressing the transcription factor Fra-1

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Increased bone formation and osteosclerosis in mice overexpressing the transcription factor Fra-1. / Jochum, W; David, J P; Elliott, C; Wutz, A; Plenk, H; Matsuo, K; Wagner, E F.

In: NAT MED, Vol. 6, No. 9, 01.09.2000, p. 980-4.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Jochum, W, David, JP, Elliott, C, Wutz, A, Plenk, H, Matsuo, K & Wagner, EF 2000, 'Increased bone formation and osteosclerosis in mice overexpressing the transcription factor Fra-1', NAT MED, vol. 6, no. 9, pp. 980-4. https://doi.org/10.1038/79676

APA

Jochum, W., David, J. P., Elliott, C., Wutz, A., Plenk, H., Matsuo, K., & Wagner, E. F. (2000). Increased bone formation and osteosclerosis in mice overexpressing the transcription factor Fra-1. NAT MED, 6(9), 980-4. https://doi.org/10.1038/79676

Vancouver

Jochum W, David JP, Elliott C, Wutz A, Plenk H, Matsuo K et al. Increased bone formation and osteosclerosis in mice overexpressing the transcription factor Fra-1. NAT MED. 2000 Sep 1;6(9):980-4. https://doi.org/10.1038/79676

Bibtex

@article{acb174fb10334fcbb4edbce122c14704,
title = "Increased bone formation and osteosclerosis in mice overexpressing the transcription factor Fra-1",
abstract = "Bone formation by osteoblasts is essential for skeletal growth and remodeling. Fra-1 is a c-Fos-related protein belonging to the AP-1 family of transcription factors. Here we show that transgenic mice overexpressing Fra-1 in various organs develop a progressive increase in bone mass leading to osteosclerosis of the entire skeleton, which is due to a cell-autonomous increase in the number of mature osteoblasts. Moreover, osteoblast differentiation, but not proliferation, was enhanced and osteoclastogenesis was also elevated in vitro. These data indicate that, unlike c-Fos, which causes osteosarcomas, Fra-1 specifically enhances bone formation, which may be exploited to stimulate bone formation in pathological conditions.",
keywords = "Animals, Calcinosis, Cell Differentiation, Mice, Mice, Transgenic, Osteoblasts, Osteosclerosis, Phenotype, Proto-Oncogene Proteins c-fos",
author = "W Jochum and David, {J P} and C Elliott and A Wutz and H Plenk and K Matsuo and Wagner, {E F}",
year = "2000",
month = sep,
day = "1",
doi = "10.1038/79676",
language = "English",
volume = "6",
pages = "980--4",
journal = "NAT MED",
issn = "1078-8956",
publisher = "NATURE PUBLISHING GROUP",
number = "9",

}

RIS

TY - JOUR

T1 - Increased bone formation and osteosclerosis in mice overexpressing the transcription factor Fra-1

AU - Jochum, W

AU - David, J P

AU - Elliott, C

AU - Wutz, A

AU - Plenk, H

AU - Matsuo, K

AU - Wagner, E F

PY - 2000/9/1

Y1 - 2000/9/1

N2 - Bone formation by osteoblasts is essential for skeletal growth and remodeling. Fra-1 is a c-Fos-related protein belonging to the AP-1 family of transcription factors. Here we show that transgenic mice overexpressing Fra-1 in various organs develop a progressive increase in bone mass leading to osteosclerosis of the entire skeleton, which is due to a cell-autonomous increase in the number of mature osteoblasts. Moreover, osteoblast differentiation, but not proliferation, was enhanced and osteoclastogenesis was also elevated in vitro. These data indicate that, unlike c-Fos, which causes osteosarcomas, Fra-1 specifically enhances bone formation, which may be exploited to stimulate bone formation in pathological conditions.

AB - Bone formation by osteoblasts is essential for skeletal growth and remodeling. Fra-1 is a c-Fos-related protein belonging to the AP-1 family of transcription factors. Here we show that transgenic mice overexpressing Fra-1 in various organs develop a progressive increase in bone mass leading to osteosclerosis of the entire skeleton, which is due to a cell-autonomous increase in the number of mature osteoblasts. Moreover, osteoblast differentiation, but not proliferation, was enhanced and osteoclastogenesis was also elevated in vitro. These data indicate that, unlike c-Fos, which causes osteosarcomas, Fra-1 specifically enhances bone formation, which may be exploited to stimulate bone formation in pathological conditions.

KW - Animals

KW - Calcinosis

KW - Cell Differentiation

KW - Mice

KW - Mice, Transgenic

KW - Osteoblasts

KW - Osteosclerosis

KW - Phenotype

KW - Proto-Oncogene Proteins c-fos

U2 - 10.1038/79676

DO - 10.1038/79676

M3 - SCORING: Journal article

C2 - 10973316

VL - 6

SP - 980

EP - 984

JO - NAT MED

JF - NAT MED

SN - 1078-8956

IS - 9

ER -