Increased beta rhythm as an indicator of inhibitory mechanisms in tourette syndrome
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Increased beta rhythm as an indicator of inhibitory mechanisms in tourette syndrome. / Niccolai, Valentina; van Dijk, Hanneke; Franzkowiak, Stephanie; Finis, Jennifer; Südmeyer, Martin; Jonas, Melanie; Thomalla, Götz; Siebner, Hartwig Roman; Müller-Vahl, Kirsten; Münchau, Alexander; Schnitzler, Alfons; Biermann-Ruben, Katja.
In: MOVEMENT DISORD, Vol. 31, No. 3, 03.2016, p. 384-392.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Increased beta rhythm as an indicator of inhibitory mechanisms in tourette syndrome
AU - Niccolai, Valentina
AU - van Dijk, Hanneke
AU - Franzkowiak, Stephanie
AU - Finis, Jennifer
AU - Südmeyer, Martin
AU - Jonas, Melanie
AU - Thomalla, Götz
AU - Siebner, Hartwig Roman
AU - Müller-Vahl, Kirsten
AU - Münchau, Alexander
AU - Schnitzler, Alfons
AU - Biermann-Ruben, Katja
N1 - © 2015 International Parkinson and Movement Disorder Society.
PY - 2016/3
Y1 - 2016/3
N2 - BACKGROUND: Inhibitory oscillatory mechanisms subserving tic compensation have been put forward in Tourette syndrome. Modulation of the beta rhythm (15-25 Hz) as the well-established oscillatory movement execution-inhibition indicator was tested during a cognitive-motor task in patients with Tourette syndrome.METHODS: Performing a Go/NoGo task, 12 patients with Tourette syndrome and 12 matched controls were recorded using whole-head magnetoencephalography.RESULTS: Compared to healthy participants, patients showed less beta suppression in the sensorimotor area and enhanced beta power in parieto-occipital brain regions contralaterally to the response hand. Average beta power and power gain correlated negatively with tic severity.CONCLUSIONS: Increased motor inhibitory as well as visuomotor attentional processes are likely to subserve tic compensation. Correlational results suggest that stronger inhibitory compensation accompanies less tic severity. © 2015 International Parkinson and Movement Disorder Society.
AB - BACKGROUND: Inhibitory oscillatory mechanisms subserving tic compensation have been put forward in Tourette syndrome. Modulation of the beta rhythm (15-25 Hz) as the well-established oscillatory movement execution-inhibition indicator was tested during a cognitive-motor task in patients with Tourette syndrome.METHODS: Performing a Go/NoGo task, 12 patients with Tourette syndrome and 12 matched controls were recorded using whole-head magnetoencephalography.RESULTS: Compared to healthy participants, patients showed less beta suppression in the sensorimotor area and enhanced beta power in parieto-occipital brain regions contralaterally to the response hand. Average beta power and power gain correlated negatively with tic severity.CONCLUSIONS: Increased motor inhibitory as well as visuomotor attentional processes are likely to subserve tic compensation. Correlational results suggest that stronger inhibitory compensation accompanies less tic severity. © 2015 International Parkinson and Movement Disorder Society.
U2 - 10.1002/mds.26454
DO - 10.1002/mds.26454
M3 - SCORING: Journal article
C2 - 26649991
VL - 31
SP - 384
EP - 392
JO - MOVEMENT DISORD
JF - MOVEMENT DISORD
SN - 0885-3185
IS - 3
ER -