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Incomplete Hippocampal Inversion: A Comprehensive MRI Study of Over 2000 Subjects

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Incomplete Hippocampal Inversion: A Comprehensive MRI Study of Over 2000 Subjects. / Cury, Claire; Toro, Roberto; Cohen, Fanny; Fischer, Clara; Mhaya, Amel; Samper-González, Jorge; Hasboun, Dominique; Mangin, Jean-François; Banaschewski, Tobias; Bokde, Arun L W; Bromberg, Uli; Cattrell, Anna; Conrod, Patricia; Flor, Herta; Gallinat, Jürgen; Garavan, Hugh; Gowland, Penny; Heinz, Andreas; Ittermann, Bernd; Lemaitre, Hervé; Martinot, Jean-Luc; Nees, Frauke; Paillère Martinot, Marie-Laure; Orfanos, Dimitri P; Paus, Tomas; Poustka, Luise; Smolka, Michael N; Walter, Henrik; Whelan, Robert; Frouin, Vincent; Schumann, Gunter; Glaunès, Joan A; Colliot, Olivier; IMAGEN Consortium ; Büchel, Christian.

In: FRONT NEUROANAT, Vol. 9, 22.12.2015, p. Art. 160.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Cury, C, Toro, R, Cohen, F, Fischer, C, Mhaya, A, Samper-González, J, Hasboun, D, Mangin, J-F, Banaschewski, T, Bokde, ALW, Bromberg, U, Cattrell, A, Conrod, P, Flor, H, Gallinat, J, Garavan, H, Gowland, P, Heinz, A, Ittermann, B, Lemaitre, H, Martinot, J-L, Nees, F, Paillère Martinot, M-L, Orfanos, DP, Paus, T, Poustka, L, Smolka, MN, Walter, H, Whelan, R, Frouin, V, Schumann, G, Glaunès, JA, Colliot, O, IMAGEN Consortium & Büchel, C 2015, 'Incomplete Hippocampal Inversion: A Comprehensive MRI Study of Over 2000 Subjects', FRONT NEUROANAT, vol. 9, pp. Art. 160. https://doi.org/10.3389/fnana.2015.00160

APA

Cury, C., Toro, R., Cohen, F., Fischer, C., Mhaya, A., Samper-González, J., Hasboun, D., Mangin, J-F., Banaschewski, T., Bokde, A. L. W., Bromberg, U., Cattrell, A., Conrod, P., Flor, H., Gallinat, J., Garavan, H., Gowland, P., Heinz, A., Ittermann, B., ... Büchel, C. (2015). Incomplete Hippocampal Inversion: A Comprehensive MRI Study of Over 2000 Subjects. FRONT NEUROANAT, 9, Art. 160. https://doi.org/10.3389/fnana.2015.00160

Vancouver

Cury C, Toro R, Cohen F, Fischer C, Mhaya A, Samper-González J et al. Incomplete Hippocampal Inversion: A Comprehensive MRI Study of Over 2000 Subjects. FRONT NEUROANAT. 2015 Dec 22;9:Art. 160. https://doi.org/10.3389/fnana.2015.00160

Bibtex

@article{63d075ec43ff4cf3ba4416544056cb9e,
title = "Incomplete Hippocampal Inversion: A Comprehensive MRI Study of Over 2000 Subjects",
abstract = "The incomplete-hippocampal-inversion (IHI), also known as malrotation, is an atypical anatomical pattern of the hippocampus, which has been reported in healthy subjects in different studies. However, extensive characterization of IHI in a large sample has not yet been performed. Furthermore, it is unclear whether IHI are restricted to the medial-temporal lobe or are associated with more extensive anatomical changes. Here, we studied the characteristics of IHI in a community-based sample of 2008 subjects of the IMAGEN database and their association with extra-hippocampal anatomical variations. The presence of IHI was assessed on T1-weighted anatomical magnetic resonance imaging (MRI) using visual criteria. We assessed the association of IHI with other anatomical changes throughout the brain using automatic morphometry of cortical sulci. We found that IHI were much more frequent in the left hippocampus (left: 17%, right: 6%, χ(2)-test, p < 10(-28)). Compared to subjects without IHI, subjects with IHI displayed morphological changes in several sulci located mainly in the limbic lobe. Our results demonstrate that IHI are a common left-sided phenomenon in normal subjects and that they are associated with morphological changes outside the medial temporal lobe.",
author = "Claire Cury and Roberto Toro and Fanny Cohen and Clara Fischer and Amel Mhaya and Jorge Samper-Gonz{\'a}lez and Dominique Hasboun and Jean-Fran{\c c}ois Mangin and Tobias Banaschewski and Bokde, {Arun L W} and Uli Bromberg and Anna Cattrell and Patricia Conrod and Herta Flor and J{\"u}rgen Gallinat and Hugh Garavan and Penny Gowland and Andreas Heinz and Bernd Ittermann and Herv{\'e} Lemaitre and Jean-Luc Martinot and Frauke Nees and {Paill{\`e}re Martinot}, Marie-Laure and Orfanos, {Dimitri P} and Tomas Paus and Luise Poustka and Smolka, {Michael N} and Henrik Walter and Robert Whelan and Vincent Frouin and Gunter Schumann and Glaun{\`e}s, {Joan A} and Olivier Colliot and {IMAGEN Consortium} and Christian B{\"u}chel",
year = "2015",
month = dec,
day = "22",
doi = "10.3389/fnana.2015.00160",
language = "English",
volume = "9",
pages = "Art. 160",
journal = "FRONT NEUROANAT",
issn = "1662-5129",
publisher = "Frontiers Research Foundation",

}

RIS

TY - JOUR

T1 - Incomplete Hippocampal Inversion: A Comprehensive MRI Study of Over 2000 Subjects

AU - Cury, Claire

AU - Toro, Roberto

AU - Cohen, Fanny

AU - Fischer, Clara

AU - Mhaya, Amel

AU - Samper-González, Jorge

AU - Hasboun, Dominique

AU - Mangin, Jean-François

AU - Banaschewski, Tobias

AU - Bokde, Arun L W

AU - Bromberg, Uli

AU - Cattrell, Anna

AU - Conrod, Patricia

AU - Flor, Herta

AU - Gallinat, Jürgen

AU - Garavan, Hugh

AU - Gowland, Penny

AU - Heinz, Andreas

AU - Ittermann, Bernd

AU - Lemaitre, Hervé

AU - Martinot, Jean-Luc

AU - Nees, Frauke

AU - Paillère Martinot, Marie-Laure

AU - Orfanos, Dimitri P

AU - Paus, Tomas

AU - Poustka, Luise

AU - Smolka, Michael N

AU - Walter, Henrik

AU - Whelan, Robert

AU - Frouin, Vincent

AU - Schumann, Gunter

AU - Glaunès, Joan A

AU - Colliot, Olivier

AU - IMAGEN Consortium

AU - Büchel, Christian

PY - 2015/12/22

Y1 - 2015/12/22

N2 - The incomplete-hippocampal-inversion (IHI), also known as malrotation, is an atypical anatomical pattern of the hippocampus, which has been reported in healthy subjects in different studies. However, extensive characterization of IHI in a large sample has not yet been performed. Furthermore, it is unclear whether IHI are restricted to the medial-temporal lobe or are associated with more extensive anatomical changes. Here, we studied the characteristics of IHI in a community-based sample of 2008 subjects of the IMAGEN database and their association with extra-hippocampal anatomical variations. The presence of IHI was assessed on T1-weighted anatomical magnetic resonance imaging (MRI) using visual criteria. We assessed the association of IHI with other anatomical changes throughout the brain using automatic morphometry of cortical sulci. We found that IHI were much more frequent in the left hippocampus (left: 17%, right: 6%, χ(2)-test, p < 10(-28)). Compared to subjects without IHI, subjects with IHI displayed morphological changes in several sulci located mainly in the limbic lobe. Our results demonstrate that IHI are a common left-sided phenomenon in normal subjects and that they are associated with morphological changes outside the medial temporal lobe.

AB - The incomplete-hippocampal-inversion (IHI), also known as malrotation, is an atypical anatomical pattern of the hippocampus, which has been reported in healthy subjects in different studies. However, extensive characterization of IHI in a large sample has not yet been performed. Furthermore, it is unclear whether IHI are restricted to the medial-temporal lobe or are associated with more extensive anatomical changes. Here, we studied the characteristics of IHI in a community-based sample of 2008 subjects of the IMAGEN database and their association with extra-hippocampal anatomical variations. The presence of IHI was assessed on T1-weighted anatomical magnetic resonance imaging (MRI) using visual criteria. We assessed the association of IHI with other anatomical changes throughout the brain using automatic morphometry of cortical sulci. We found that IHI were much more frequent in the left hippocampus (left: 17%, right: 6%, χ(2)-test, p < 10(-28)). Compared to subjects without IHI, subjects with IHI displayed morphological changes in several sulci located mainly in the limbic lobe. Our results demonstrate that IHI are a common left-sided phenomenon in normal subjects and that they are associated with morphological changes outside the medial temporal lobe.

U2 - 10.3389/fnana.2015.00160

DO - 10.3389/fnana.2015.00160

M3 - SCORING: Journal article

C2 - 26733822

VL - 9

SP - Art. 160

JO - FRONT NEUROANAT

JF - FRONT NEUROANAT

SN - 1662-5129

ER -