Incidence of pulmonary embolism and impact on mortality in patients with malignant melanoma
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Incidence of pulmonary embolism and impact on mortality in patients with malignant melanoma. / Rennebaum, Shereen; Schneider, Stefan W; Henzler, Thomas; Desch, Anna; Weiß, Christel; Haubenreisser, Holger; Goerdt, Sergij; Morelli, John N; Utikal, Jochen S; Schoenberg, Stefan O; Riffel, Julia.
In: CLIN IMAG, Vol. 83, 03.2022, p. 72-76.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Incidence of pulmonary embolism and impact on mortality in patients with malignant melanoma
AU - Rennebaum, Shereen
AU - Schneider, Stefan W
AU - Henzler, Thomas
AU - Desch, Anna
AU - Weiß, Christel
AU - Haubenreisser, Holger
AU - Goerdt, Sergij
AU - Morelli, John N
AU - Utikal, Jochen S
AU - Schoenberg, Stefan O
AU - Riffel, Julia
N1 - Copyright © 2022 Elsevier Inc. All rights reserved.
PY - 2022/3
Y1 - 2022/3
N2 - PURPOSE: Pulmonary embolism (PE) occurs frequently in patients with malignant melanoma (MM). The aim of this study is to determine the incidence of PE in patients with MM and to assess the clinical characteristics and mortality of MM patients with PE.MATERIAL AND METHODS: Medical records from 381 MM patients who underwent contrast-enhanced computed tomography were evaluated. Imaging parameters including location of PE and measurements of right heart dysfunction and clinical parameters including D-Dimer levels, local and distant tumor stage and time of death were analyzed.RESULTS: PE was found in 23/381 (6%) MM patients, whereby 17/23 (74%) were detected incidentally and only 6/23 (26%) were symptomatic. The presence of PE significantly correlated with elevated D-Dimers (p < 0.001), right ventricular dysfunction (p = 0.04), higher local tumor stage (≥T3) (p = 0.05), presence of visceral (p = 0.02) or cerebral metastases (p = 0.03) and increased mortality (p = 0.05). Further, patients with central PE showed an increased mortality compared to peripheral PE (p = 0.03), but no correlation was found between the localization of PE and the occurrence of clinical symptoms (p = 0.36).CONCLUSION: PE in patients with MM often occurs without clinical symptoms and is indicative for advanced disease and a poorer prognosis.
AB - PURPOSE: Pulmonary embolism (PE) occurs frequently in patients with malignant melanoma (MM). The aim of this study is to determine the incidence of PE in patients with MM and to assess the clinical characteristics and mortality of MM patients with PE.MATERIAL AND METHODS: Medical records from 381 MM patients who underwent contrast-enhanced computed tomography were evaluated. Imaging parameters including location of PE and measurements of right heart dysfunction and clinical parameters including D-Dimer levels, local and distant tumor stage and time of death were analyzed.RESULTS: PE was found in 23/381 (6%) MM patients, whereby 17/23 (74%) were detected incidentally and only 6/23 (26%) were symptomatic. The presence of PE significantly correlated with elevated D-Dimers (p < 0.001), right ventricular dysfunction (p = 0.04), higher local tumor stage (≥T3) (p = 0.05), presence of visceral (p = 0.02) or cerebral metastases (p = 0.03) and increased mortality (p = 0.05). Further, patients with central PE showed an increased mortality compared to peripheral PE (p = 0.03), but no correlation was found between the localization of PE and the occurrence of clinical symptoms (p = 0.36).CONCLUSION: PE in patients with MM often occurs without clinical symptoms and is indicative for advanced disease and a poorer prognosis.
KW - Humans
KW - Incidence
KW - Melanoma/diagnostic imaging
KW - Pulmonary Embolism/diagnostic imaging
KW - Retrospective Studies
KW - Ventricular Dysfunction, Right/etiology
U2 - 10.1016/j.clinimag.2021.12.012
DO - 10.1016/j.clinimag.2021.12.012
M3 - SCORING: Journal article
C2 - 34990983
VL - 83
SP - 72
EP - 76
JO - CLIN IMAG
JF - CLIN IMAG
SN - 0899-7071
ER -
