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Incidence of HAV and HBV infections and vaccination rates in patients with autoimmune liver diseases.

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Incidence of HAV and HBV infections and vaccination rates in patients with autoimmune liver diseases. / Wörns, Marcus A; Teufel, Andreas; Kanzler, Stephan; Shrestha, Annette; Victor, Anja; Otto, Gerd; Lohse, Ansgar W.; Galle, Peter R; Höhler, Thomas.

In: AM J GASTROENTEROL, Vol. 103, No. 1, 1, 2008, p. 138-146.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Wörns, MA, Teufel, A, Kanzler, S, Shrestha, A, Victor, A, Otto, G, Lohse, AW, Galle, PR & Höhler, T 2008, 'Incidence of HAV and HBV infections and vaccination rates in patients with autoimmune liver diseases.', AM J GASTROENTEROL, vol. 103, no. 1, 1, pp. 138-146. <http://www.ncbi.nlm.nih.gov/pubmed/17970833?dopt=Citation>

APA

Wörns, M. A., Teufel, A., Kanzler, S., Shrestha, A., Victor, A., Otto, G., Lohse, A. W., Galle, P. R., & Höhler, T. (2008). Incidence of HAV and HBV infections and vaccination rates in patients with autoimmune liver diseases. AM J GASTROENTEROL, 103(1), 138-146. [1]. http://www.ncbi.nlm.nih.gov/pubmed/17970833?dopt=Citation

Vancouver

Wörns MA, Teufel A, Kanzler S, Shrestha A, Victor A, Otto G et al. Incidence of HAV and HBV infections and vaccination rates in patients with autoimmune liver diseases. AM J GASTROENTEROL. 2008;103(1):138-146. 1.

Bibtex

@article{ee8e428e09254c11afde99a741d8f636,
title = "Incidence of HAV and HBV infections and vaccination rates in patients with autoimmune liver diseases.",
abstract = "OBJECTIVES: Hepatitis A virus (HAV) or hepatitis B virus (HBV) superinfection is associated with an increased mortality in patients with chronic liver diseases (CLD). Despite official recommendations, it was reported that the vaccination rate against HAV is low in patients with chronic hepatitis C infection. To evaluate the situation in patients with autoimmune liver diseases, we conducted a retrospective cohort study. METHODS: Susceptibility to HAV and HBV infections, course of HAV and HBV infections, vaccination rates against HAV and HBV, and efficacy of hepatitis A/B vaccines were evaluated by antibody testing in 225 patients with autoimmune liver diseases during 1,677 person-years. RESULTS: Susceptibility to HAV/HBV infection was 51/86%. Incidence of HAV/HBV infection was 1.3/1.4 per 1,000 person-years. One HAV infection occurred, but the patient recovered spontaneously. Two patients were HBV-infected after receiving an anti-HBc-positive (antibody to hepatitis B core antigen) donor graft during orthotopic liver transplantation, and one of them developed chronic HBV infection. Vaccination rates were 11% (HBV) and 13% (HAV), respectively. Seventy-six percent of the vaccinated patients (HBV vaccine) developed anti-HBs (antibody to hepatitis surface antigen) >or=10 UI/L. Ten out of 13 vaccinated patients, showing a low or nonresponse to hepatitis B vaccine, had concomitant immunosuppressive therapy. Anti-HAV was detectable in all patients after administration of HAV vaccine. CONCLUSIONS: Patients with autoimmune liver diseases have a high susceptibility to HAV and HBV infections. Vaccination rates are low in this patient cohort and efficacy of hepatitis B vaccine is reduced due to immunosuppressive therapy. Improving adherence to vaccine recommendations is essential to prevent HAV and HBV infections in patients with autoimmune liver diseases.",
author = "W{\"o}rns, {Marcus A} and Andreas Teufel and Stephan Kanzler and Annette Shrestha and Anja Victor and Gerd Otto and Lohse, {Ansgar W.} and Galle, {Peter R} and Thomas H{\"o}hler",
year = "2008",
language = "Deutsch",
volume = "103",
pages = "138--146",
journal = "AM J GASTROENTEROL",
issn = "0002-9270",
publisher = "NATURE PUBLISHING GROUP",
number = "1",

}

RIS

TY - JOUR

T1 - Incidence of HAV and HBV infections and vaccination rates in patients with autoimmune liver diseases.

AU - Wörns, Marcus A

AU - Teufel, Andreas

AU - Kanzler, Stephan

AU - Shrestha, Annette

AU - Victor, Anja

AU - Otto, Gerd

AU - Lohse, Ansgar W.

AU - Galle, Peter R

AU - Höhler, Thomas

PY - 2008

Y1 - 2008

N2 - OBJECTIVES: Hepatitis A virus (HAV) or hepatitis B virus (HBV) superinfection is associated with an increased mortality in patients with chronic liver diseases (CLD). Despite official recommendations, it was reported that the vaccination rate against HAV is low in patients with chronic hepatitis C infection. To evaluate the situation in patients with autoimmune liver diseases, we conducted a retrospective cohort study. METHODS: Susceptibility to HAV and HBV infections, course of HAV and HBV infections, vaccination rates against HAV and HBV, and efficacy of hepatitis A/B vaccines were evaluated by antibody testing in 225 patients with autoimmune liver diseases during 1,677 person-years. RESULTS: Susceptibility to HAV/HBV infection was 51/86%. Incidence of HAV/HBV infection was 1.3/1.4 per 1,000 person-years. One HAV infection occurred, but the patient recovered spontaneously. Two patients were HBV-infected after receiving an anti-HBc-positive (antibody to hepatitis B core antigen) donor graft during orthotopic liver transplantation, and one of them developed chronic HBV infection. Vaccination rates were 11% (HBV) and 13% (HAV), respectively. Seventy-six percent of the vaccinated patients (HBV vaccine) developed anti-HBs (antibody to hepatitis surface antigen) >or=10 UI/L. Ten out of 13 vaccinated patients, showing a low or nonresponse to hepatitis B vaccine, had concomitant immunosuppressive therapy. Anti-HAV was detectable in all patients after administration of HAV vaccine. CONCLUSIONS: Patients with autoimmune liver diseases have a high susceptibility to HAV and HBV infections. Vaccination rates are low in this patient cohort and efficacy of hepatitis B vaccine is reduced due to immunosuppressive therapy. Improving adherence to vaccine recommendations is essential to prevent HAV and HBV infections in patients with autoimmune liver diseases.

AB - OBJECTIVES: Hepatitis A virus (HAV) or hepatitis B virus (HBV) superinfection is associated with an increased mortality in patients with chronic liver diseases (CLD). Despite official recommendations, it was reported that the vaccination rate against HAV is low in patients with chronic hepatitis C infection. To evaluate the situation in patients with autoimmune liver diseases, we conducted a retrospective cohort study. METHODS: Susceptibility to HAV and HBV infections, course of HAV and HBV infections, vaccination rates against HAV and HBV, and efficacy of hepatitis A/B vaccines were evaluated by antibody testing in 225 patients with autoimmune liver diseases during 1,677 person-years. RESULTS: Susceptibility to HAV/HBV infection was 51/86%. Incidence of HAV/HBV infection was 1.3/1.4 per 1,000 person-years. One HAV infection occurred, but the patient recovered spontaneously. Two patients were HBV-infected after receiving an anti-HBc-positive (antibody to hepatitis B core antigen) donor graft during orthotopic liver transplantation, and one of them developed chronic HBV infection. Vaccination rates were 11% (HBV) and 13% (HAV), respectively. Seventy-six percent of the vaccinated patients (HBV vaccine) developed anti-HBs (antibody to hepatitis surface antigen) >or=10 UI/L. Ten out of 13 vaccinated patients, showing a low or nonresponse to hepatitis B vaccine, had concomitant immunosuppressive therapy. Anti-HAV was detectable in all patients after administration of HAV vaccine. CONCLUSIONS: Patients with autoimmune liver diseases have a high susceptibility to HAV and HBV infections. Vaccination rates are low in this patient cohort and efficacy of hepatitis B vaccine is reduced due to immunosuppressive therapy. Improving adherence to vaccine recommendations is essential to prevent HAV and HBV infections in patients with autoimmune liver diseases.

M3 - SCORING: Zeitschriftenaufsatz

VL - 103

SP - 138

EP - 146

JO - AM J GASTROENTEROL

JF - AM J GASTROENTEROL

SN - 0002-9270

IS - 1

M1 - 1

ER -