Incidence of BK polyomavirus infection after kidney transplantation is independent of type of immunosuppressive therapy
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Incidence of BK polyomavirus infection after kidney transplantation is independent of type of immunosuppressive therapy. / Radtke, Josephine; Dietze, Nina ; Fischer, Lutz; Achilles, Eike-Gert; Li, Jun; Scheidat, Silke ; Thaiss, Friedrich; Nashan, Bjoern; Koch, Martina.
In: TRANSPL INFECT DIS, Vol. 18, No. 6, 12.2016, p. 850-855.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Incidence of BK polyomavirus infection after kidney transplantation is independent of type of immunosuppressive therapy
AU - Radtke, Josephine
AU - Dietze, Nina
AU - Fischer, Lutz
AU - Achilles, Eike-Gert
AU - Li, Jun
AU - Scheidat, Silke
AU - Thaiss, Friedrich
AU - Nashan, Bjoern
AU - Koch, Martina
N1 - © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
PY - 2016/12
Y1 - 2016/12
N2 - BACKGROUND: BK polyomavirus (BKV) infection and BKV nephropathy (BKVN) are risk factors for allograft function and survival.METHODS: We retrospectively analyzed BK viremia and BKVN in 348 patients who received a kidney transplantation donated after brain death (n=232) or living donation (n=116) between 2008 and 2013. A total of 266 patients were treated with standard immunosuppression consisting of basiliximab induction, calcineurin inhibitor (CNI), and mycophenolic acid (MPA, n=219) or everolimus (n=47); 82 patients received more intense immunosuppression with lymphocyte depletion, CNI and MPA (n=38) or everolimus (n=44).RESULTS: BK viremia occurred in 33 (9.5%) patients in the first year and in 7 (2.0%) recipients in the second year after transplantation. BKVN occurred in 4 (1.1%) patients in the first year. Donor and recipient age, diabetes, previous transplantation, and type of transplantation (donated after brain death vs living donation) were not risk factors (P>.05). BK incidence did not differ depending on induction or maintenance immunosuppression.CONCLUSION: Incidence of BK viremia is independent of recipient characteristics, type of transplantation as well as induction and maintenance immunosuppression.
AB - BACKGROUND: BK polyomavirus (BKV) infection and BKV nephropathy (BKVN) are risk factors for allograft function and survival.METHODS: We retrospectively analyzed BK viremia and BKVN in 348 patients who received a kidney transplantation donated after brain death (n=232) or living donation (n=116) between 2008 and 2013. A total of 266 patients were treated with standard immunosuppression consisting of basiliximab induction, calcineurin inhibitor (CNI), and mycophenolic acid (MPA, n=219) or everolimus (n=47); 82 patients received more intense immunosuppression with lymphocyte depletion, CNI and MPA (n=38) or everolimus (n=44).RESULTS: BK viremia occurred in 33 (9.5%) patients in the first year and in 7 (2.0%) recipients in the second year after transplantation. BKVN occurred in 4 (1.1%) patients in the first year. Donor and recipient age, diabetes, previous transplantation, and type of transplantation (donated after brain death vs living donation) were not risk factors (P>.05). BK incidence did not differ depending on induction or maintenance immunosuppression.CONCLUSION: Incidence of BK viremia is independent of recipient characteristics, type of transplantation as well as induction and maintenance immunosuppression.
U2 - 10.1111/tid.12611
DO - 10.1111/tid.12611
M3 - SCORING: Journal article
C2 - 27639176
VL - 18
SP - 850
EP - 855
JO - TRANSPL INFECT DIS
JF - TRANSPL INFECT DIS
SN - 1398-2273
IS - 6
ER -
