Incidence of acute pancreatitis does not increase during Oktoberfest, but is higher than previously described in Germany
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Incidence of acute pancreatitis does not increase during Oktoberfest, but is higher than previously described in Germany. / Phillip, Veit; Huber, Wolfgang; Hagemes, Frank; Lorenz, Sandra; Matheis, Ulrike; Preinfalk, Sigrid; Schuster, Tibor; Lippl, Florian; Saugel, Bernd; Schmid, Roland M.
In: CLIN GASTROENTEROL H, Vol. 9, No. 11, 01.11.2011, p. 995-1000.e3.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Incidence of acute pancreatitis does not increase during Oktoberfest, but is higher than previously described in Germany
AU - Phillip, Veit
AU - Huber, Wolfgang
AU - Hagemes, Frank
AU - Lorenz, Sandra
AU - Matheis, Ulrike
AU - Preinfalk, Sigrid
AU - Schuster, Tibor
AU - Lippl, Florian
AU - Saugel, Bernd
AU - Schmid, Roland M
N1 - Copyright © 2011 AGA Institute. Published by Elsevier Inc. All rights reserved.
PY - 2011/11/1
Y1 - 2011/11/1
N2 - BACKGROUND & AIMS: Increased alcohol consumption can lead to acute pancreatitis (AP). We investigated whether the incidence of alcohol-induced AP increased during the Munich Oktoberfest in 2008, at which 6.6 million liters of beer were sold within 16 days.METHODS: We performed a multicenter, prospective study of 188 patients with AP (36.7% alcohol-induced, 34.6% biliary), treated at 27 hospitals in the greater area of Munich, Germany (2,970,000 inhabitants) during the 2008 Oktoberfest. Data were compared with that from two 18-day control periods.RESULTS: During the Oktoberfest, the overall incidence of AP was 42.8/100,000 person-years, which is 117% higher than previously reported. The incidence of acute attacks of alcoholic pancreatitis (AAP) did not increase during the Oktoberfest, compared with control periods. AAP was independently associated with repeated episodes of AP (P = .001), high levels of chronic alcohol intake (P = .001), low body-mass index (P = .007), male gender (P = .033), and acute alcohol excess (P = .037). Biliary AP was associated with increased levels of alanine-aminotransferase and aspartate-aminotransferase (P = .003), old age (P = .014), and low levels of chronic alcohol intake (P = .032). Death (5/188 patients) was associated with baseline levels of blood urea nitrogen, receiver operating characteristic-area under the curve (ROC-AUC = 0.918), alkaline phosphatase (ROC-AUC = 0.861), and C-reactive protein (ROC-AUC = 0.855).CONCLUSIONS: The incidence of AP does not increase during the Oktoberfest, compared with other time periods; the incidence of AP in Munich is higher than previously described in Germany. AAP was associated with long-term, heavy alcohol exposure rather than short-term, excessive alcohol drinking. Levels of blood urea nitrogen were associated with mortality.
AB - BACKGROUND & AIMS: Increased alcohol consumption can lead to acute pancreatitis (AP). We investigated whether the incidence of alcohol-induced AP increased during the Munich Oktoberfest in 2008, at which 6.6 million liters of beer were sold within 16 days.METHODS: We performed a multicenter, prospective study of 188 patients with AP (36.7% alcohol-induced, 34.6% biliary), treated at 27 hospitals in the greater area of Munich, Germany (2,970,000 inhabitants) during the 2008 Oktoberfest. Data were compared with that from two 18-day control periods.RESULTS: During the Oktoberfest, the overall incidence of AP was 42.8/100,000 person-years, which is 117% higher than previously reported. The incidence of acute attacks of alcoholic pancreatitis (AAP) did not increase during the Oktoberfest, compared with control periods. AAP was independently associated with repeated episodes of AP (P = .001), high levels of chronic alcohol intake (P = .001), low body-mass index (P = .007), male gender (P = .033), and acute alcohol excess (P = .037). Biliary AP was associated with increased levels of alanine-aminotransferase and aspartate-aminotransferase (P = .003), old age (P = .014), and low levels of chronic alcohol intake (P = .032). Death (5/188 patients) was associated with baseline levels of blood urea nitrogen, receiver operating characteristic-area under the curve (ROC-AUC = 0.918), alkaline phosphatase (ROC-AUC = 0.861), and C-reactive protein (ROC-AUC = 0.855).CONCLUSIONS: The incidence of AP does not increase during the Oktoberfest, compared with other time periods; the incidence of AP in Munich is higher than previously described in Germany. AAP was associated with long-term, heavy alcohol exposure rather than short-term, excessive alcohol drinking. Levels of blood urea nitrogen were associated with mortality.
KW - Adult
KW - Aged
KW - Alcohol Drinking
KW - Female
KW - Germany
KW - Humans
KW - Incidence
KW - Male
KW - Middle Aged
KW - Pancreatitis, Acute Necrotizing
KW - Prospective Studies
U2 - 10.1016/j.cgh.2011.06.016
DO - 10.1016/j.cgh.2011.06.016
M3 - SCORING: Journal article
C2 - 21723238
VL - 9
SP - 995-1000.e3
JO - CLIN GASTROENTEROL H
JF - CLIN GASTROENTEROL H
SN - 1542-3565
IS - 11
ER -
