Incidence, clinical presentation, management, and outcome of acute pericarditis and myopericarditis
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Incidence, clinical presentation, management, and outcome of acute pericarditis and myopericarditis. / Prepoudis, Alexandra; Koechlin, Luca; Nestelberger, Thomas; Boeddinghaus, Jasper; Lopez-Ayala, Pedro; Wussler, Desiree; Zimmermann, Tobias; Rubini Giménez, Maria; Strebel, Ivo; Puelacher, Christian; Shrestha, Samyut; Keller, Dagmar I; Christ, Michael; Gualandro, Danielle M; Twerenbold, Raphael; Martinez-Nadal, Gemma; Lopez-Barbeito, Beatriz; Miro, Oscar; Mueller, Christian.
In: EUR HEART J-ACUTE CA, Vol. 11, No. 2, 08.02.2022, p. 137-147.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Incidence, clinical presentation, management, and outcome of acute pericarditis and myopericarditis
AU - Prepoudis, Alexandra
AU - Koechlin, Luca
AU - Nestelberger, Thomas
AU - Boeddinghaus, Jasper
AU - Lopez-Ayala, Pedro
AU - Wussler, Desiree
AU - Zimmermann, Tobias
AU - Rubini Giménez, Maria
AU - Strebel, Ivo
AU - Puelacher, Christian
AU - Shrestha, Samyut
AU - Keller, Dagmar I
AU - Christ, Michael
AU - Gualandro, Danielle M
AU - Twerenbold, Raphael
AU - Martinez-Nadal, Gemma
AU - Lopez-Barbeito, Beatriz
AU - Miro, Oscar
AU - Mueller, Christian
N1 - Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2021. For permissions, please email: journals.permissions@oup.com.
PY - 2022/2/8
Y1 - 2022/2/8
N2 - AIMS: Little is known about the epidemiology, clinical presentation, management, and outcome of acute pericarditis and myopericarditis.METHODS AND RESULTS: The final diagnoses of acute pericarditis, myopericarditis, and non-ST-segment elevation myocardial infarction (NSTEMI) of patients presenting to seven emergency departments in Switzerland with acute chest pain were centrally adjudicated by two independent cardiologists using all information including serial measurements of high-sensitivity cardiac troponin T. The overall incidence of pericarditis and myopericarditis was estimated relative to the established incidence of NSTEMI. Current management and long-term outcome of both conditions were also assessed. Among 2533 chest pain patients, the incidence of pericarditis, myopericarditis, and NSTEMI were 1.9% (n = 48), 1.1% (n = 29), and 21.6% (n = 548), respectively. Accordingly, the estimated incidence of pericarditis and myopericarditis in Switzerland was 10.1 [95% confidence interval (95% CI) 9.3-10.9] and 6.1 (95% CI 5.6-6.7) cases per 100 000 population per year, respectively, vs. 115.0 (95% CI 112.3-117.6) cases per 100 000 population per year for NSTEMI. Pericarditis (85% male, median age 46 years) and myopericarditis (62% male, median age 56 years) had male predominance, and commonly (50% and 97%, respectively) resulted in hospitalization. No patient with pericarditis or myopericarditis died or had life-threatening arrhythmias within 30 days [incidence 0% (95% CI 0.0-4.8%)]. Compared with NSTEMI, the 2-year all-cause mortality adjusted hazard ratio of pericarditis and myopericarditis was 0.40 (95% CI 0.05-2.96), being 0.59 (95% CI 0.40-0.88) for non-cardiac causes of chest pain.CONCLUSION: Pericarditis and myopericarditis are substantially less common than NSTEMI and have an excellent short- and long-term outcome.CLINICAL TRIAL REGISTRATION: ClinicalTrial.gov, number NCT00470587, https://clinicaltrials.gov/ct2/show/NCT00470587.
AB - AIMS: Little is known about the epidemiology, clinical presentation, management, and outcome of acute pericarditis and myopericarditis.METHODS AND RESULTS: The final diagnoses of acute pericarditis, myopericarditis, and non-ST-segment elevation myocardial infarction (NSTEMI) of patients presenting to seven emergency departments in Switzerland with acute chest pain were centrally adjudicated by two independent cardiologists using all information including serial measurements of high-sensitivity cardiac troponin T. The overall incidence of pericarditis and myopericarditis was estimated relative to the established incidence of NSTEMI. Current management and long-term outcome of both conditions were also assessed. Among 2533 chest pain patients, the incidence of pericarditis, myopericarditis, and NSTEMI were 1.9% (n = 48), 1.1% (n = 29), and 21.6% (n = 548), respectively. Accordingly, the estimated incidence of pericarditis and myopericarditis in Switzerland was 10.1 [95% confidence interval (95% CI) 9.3-10.9] and 6.1 (95% CI 5.6-6.7) cases per 100 000 population per year, respectively, vs. 115.0 (95% CI 112.3-117.6) cases per 100 000 population per year for NSTEMI. Pericarditis (85% male, median age 46 years) and myopericarditis (62% male, median age 56 years) had male predominance, and commonly (50% and 97%, respectively) resulted in hospitalization. No patient with pericarditis or myopericarditis died or had life-threatening arrhythmias within 30 days [incidence 0% (95% CI 0.0-4.8%)]. Compared with NSTEMI, the 2-year all-cause mortality adjusted hazard ratio of pericarditis and myopericarditis was 0.40 (95% CI 0.05-2.96), being 0.59 (95% CI 0.40-0.88) for non-cardiac causes of chest pain.CONCLUSION: Pericarditis and myopericarditis are substantially less common than NSTEMI and have an excellent short- and long-term outcome.CLINICAL TRIAL REGISTRATION: ClinicalTrial.gov, number NCT00470587, https://clinicaltrials.gov/ct2/show/NCT00470587.
U2 - 10.1093/ehjacc/zuab108
DO - 10.1093/ehjacc/zuab108
M3 - SCORING: Journal article
C2 - 34849666
VL - 11
SP - 137
EP - 147
JO - EUR HEART J-ACUTE CA
JF - EUR HEART J-ACUTE CA
SN - 2048-8726
IS - 2
ER -
