Research ExplorerPublicationsIncidence and prognostic impact of bleeding and transfusion ...

Incidence and prognostic impact of bleeding and transfusion after coronary surgery in low-risk patients

Standard

Incidence and prognostic impact of bleeding and transfusion after coronary surgery in low-risk patients. / Kinnunen, Eeva-Maija; De Feo, Marisa; Reichart, Daniel; Tauriainen, Tuomas; Gatti, Giuseppe; Onorati, Francesco; Maschietto, Luca; Bancone, Ciro; Fiorentino, Francesca; Chocron, Sidney; Bounader, Karl; Dalén, Magnus; Svenarud, Peter; Faggian, Giuseppe; Franzese, Ilaria; Santarpino, Giuseppe; Fischlein, Theodor; Maselli, Daniele; Dominici, Carmelo; Nardella, Saverio; Gherli, Riccardo; Musumeci, Francesco; Rubino, Antonino S; Mignosa, Carmelo; Mariscalco, Giovanni; Serraino, Filiberto G; Santini, Francesco; Salsano, Antonio; Nicolini, Francesco; Gherli, Tiziano; Zanobini, Marco; Saccocci, Matteo; Ruggieri, Vito G; Philippe Verhoye, Jean; Perrotti, Andrea; Biancari, Fausto.

In: TRANSFUSION, Vol. 57, No. 1, 01.2017, p. 178-186.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Kinnunen, E-M, De Feo, M, Reichart, D, Tauriainen, T, Gatti, G, Onorati, F, Maschietto, L, Bancone, C, Fiorentino, F, Chocron, S, Bounader, K, Dalén, M, Svenarud, P, Faggian, G, Franzese, I, Santarpino, G, Fischlein, T, Maselli, D, Dominici, C, Nardella, S, Gherli, R, Musumeci, F, Rubino, AS, Mignosa, C, Mariscalco, G, Serraino, FG, Santini, F, Salsano, A, Nicolini, F, Gherli, T, Zanobini, M, Saccocci, M, Ruggieri, VG, Philippe Verhoye, J, Perrotti, A & Biancari, F 2017, 'Incidence and prognostic impact of bleeding and transfusion after coronary surgery in low-risk patients', TRANSFUSION, vol. 57, no. 1, pp. 178-186. https://doi.org/10.1111/trf.13885

APA

Kinnunen, E-M., De Feo, M., Reichart, D., Tauriainen, T., Gatti, G., Onorati, F., Maschietto, L., Bancone, C., Fiorentino, F., Chocron, S., Bounader, K., Dalén, M., Svenarud, P., Faggian, G., Franzese, I., Santarpino, G., Fischlein, T., Maselli, D., Dominici, C., ... Biancari, F. (2017). Incidence and prognostic impact of bleeding and transfusion after coronary surgery in low-risk patients. TRANSFUSION, 57(1), 178-186. https://doi.org/10.1111/trf.13885

Vancouver

Kinnunen E-M, De Feo M, Reichart D, Tauriainen T, Gatti G, Onorati F et al. Incidence and prognostic impact of bleeding and transfusion after coronary surgery in low-risk patients. TRANSFUSION. 2017 Jan;57(1):178-186. https://doi.org/10.1111/trf.13885

Bibtex

@article{fe139a3d82c34121834e1907daa88776,
title = "Incidence and prognostic impact of bleeding and transfusion after coronary surgery in low-risk patients",
abstract = "BACKGROUND: Excessive bleeding and blood transfusion are associated with adverse outcome after cardiac surgery, but their mechanistic effects are difficult to disentangle in patients with increased operative risk. This study aimed to evaluate the incidence and prognostic impact of bleeding and transfusion of blood products in low-risk patients undergoing coronary artery bypass grafting (CABG).STUDY DESIGN AND METHODS: Sixteen tertiary European centers of cardiac surgery contributed to the prospective European registry of CABG (E-CABG). The severity of bleeding was defined by the E-CABG bleeding severity classification and universal definition of perioperative bleeding (UDPB) classification.RESULTS: Of 1213 patients with EuroSCORE II of less than 2% (mean, 1.1 ± 0.4%), 18.5% suffered from mild bleeding (E-CABG bleeding Grade 1) and 3.4% experienced severe bleeding (E-CABG bleeding Grade 2-3). Similarly, 19.7% had UDPB Class 2 and 5.9% had UDPB Classes 3 and 4. Mild and severe bleeding defined by the E-CABG and UDPB classifications were associated with an increased risk of several adverse events as adjusted by multiple covariates. The risk of death, stroke, and acute kidney injury was particularly increased in patients with severe bleeding.CONCLUSION: Severe bleeding is rather uncommon in low-risk patients undergoing CABG, but it is associated with an increased risk of major adverse events. Prevention of excessive perioperative bleeding and patient blood management may improve the outcome of cardiac surgery also in low-risk patients.",
keywords = "Aged, Blood Transfusion, Coronary Artery Bypass/adverse effects, Europe/epidemiology, Female, Humans, Incidence, Male, Middle Aged, Postoperative Hemorrhage/diagnosis, Prognosis, Prospective Studies, Registries, Risk Factors, Tertiary Care Centers",
author = "Eeva-Maija Kinnunen and {De Feo}, Marisa and Daniel Reichart and Tuomas Tauriainen and Giuseppe Gatti and Francesco Onorati and Luca Maschietto and Ciro Bancone and Francesca Fiorentino and Sidney Chocron and Karl Bounader and Magnus Dal{\'e}n and Peter Svenarud and Giuseppe Faggian and Ilaria Franzese and Giuseppe Santarpino and Theodor Fischlein and Daniele Maselli and Carmelo Dominici and Saverio Nardella and Riccardo Gherli and Francesco Musumeci and Rubino, {Antonino S} and Carmelo Mignosa and Giovanni Mariscalco and Serraino, {Filiberto G} and Francesco Santini and Antonio Salsano and Francesco Nicolini and Tiziano Gherli and Marco Zanobini and Matteo Saccocci and Ruggieri, {Vito G} and {Philippe Verhoye}, Jean and Andrea Perrotti and Fausto Biancari",
note = "{\textcopyright} 2016 AABB.",
year = "2017",
month = jan,
doi = "10.1111/trf.13885",
language = "English",
volume = "57",
pages = "178--186",
journal = "TRANSFUSION",
issn = "0041-1132",
publisher = "Wiley-Blackwell",
number = "1",

}

RIS

TY - JOUR

T1 - Incidence and prognostic impact of bleeding and transfusion after coronary surgery in low-risk patients

AU - Kinnunen, Eeva-Maija

AU - De Feo, Marisa

AU - Reichart, Daniel

AU - Tauriainen, Tuomas

AU - Gatti, Giuseppe

AU - Onorati, Francesco

AU - Maschietto, Luca

AU - Bancone, Ciro

AU - Fiorentino, Francesca

AU - Chocron, Sidney

AU - Bounader, Karl

AU - Dalén, Magnus

AU - Svenarud, Peter

AU - Faggian, Giuseppe

AU - Franzese, Ilaria

AU - Santarpino, Giuseppe

AU - Fischlein, Theodor

AU - Maselli, Daniele

AU - Dominici, Carmelo

AU - Nardella, Saverio

AU - Gherli, Riccardo

AU - Musumeci, Francesco

AU - Rubino, Antonino S

AU - Mignosa, Carmelo

AU - Mariscalco, Giovanni

AU - Serraino, Filiberto G

AU - Santini, Francesco

AU - Salsano, Antonio

AU - Nicolini, Francesco

AU - Gherli, Tiziano

AU - Zanobini, Marco

AU - Saccocci, Matteo

AU - Ruggieri, Vito G

AU - Philippe Verhoye, Jean

AU - Perrotti, Andrea

AU - Biancari, Fausto

N1 - © 2016 AABB.

PY - 2017/1

Y1 - 2017/1

N2 - BACKGROUND: Excessive bleeding and blood transfusion are associated with adverse outcome after cardiac surgery, but their mechanistic effects are difficult to disentangle in patients with increased operative risk. This study aimed to evaluate the incidence and prognostic impact of bleeding and transfusion of blood products in low-risk patients undergoing coronary artery bypass grafting (CABG).STUDY DESIGN AND METHODS: Sixteen tertiary European centers of cardiac surgery contributed to the prospective European registry of CABG (E-CABG). The severity of bleeding was defined by the E-CABG bleeding severity classification and universal definition of perioperative bleeding (UDPB) classification.RESULTS: Of 1213 patients with EuroSCORE II of less than 2% (mean, 1.1 ± 0.4%), 18.5% suffered from mild bleeding (E-CABG bleeding Grade 1) and 3.4% experienced severe bleeding (E-CABG bleeding Grade 2-3). Similarly, 19.7% had UDPB Class 2 and 5.9% had UDPB Classes 3 and 4. Mild and severe bleeding defined by the E-CABG and UDPB classifications were associated with an increased risk of several adverse events as adjusted by multiple covariates. The risk of death, stroke, and acute kidney injury was particularly increased in patients with severe bleeding.CONCLUSION: Severe bleeding is rather uncommon in low-risk patients undergoing CABG, but it is associated with an increased risk of major adverse events. Prevention of excessive perioperative bleeding and patient blood management may improve the outcome of cardiac surgery also in low-risk patients.

AB - BACKGROUND: Excessive bleeding and blood transfusion are associated with adverse outcome after cardiac surgery, but their mechanistic effects are difficult to disentangle in patients with increased operative risk. This study aimed to evaluate the incidence and prognostic impact of bleeding and transfusion of blood products in low-risk patients undergoing coronary artery bypass grafting (CABG).STUDY DESIGN AND METHODS: Sixteen tertiary European centers of cardiac surgery contributed to the prospective European registry of CABG (E-CABG). The severity of bleeding was defined by the E-CABG bleeding severity classification and universal definition of perioperative bleeding (UDPB) classification.RESULTS: Of 1213 patients with EuroSCORE II of less than 2% (mean, 1.1 ± 0.4%), 18.5% suffered from mild bleeding (E-CABG bleeding Grade 1) and 3.4% experienced severe bleeding (E-CABG bleeding Grade 2-3). Similarly, 19.7% had UDPB Class 2 and 5.9% had UDPB Classes 3 and 4. Mild and severe bleeding defined by the E-CABG and UDPB classifications were associated with an increased risk of several adverse events as adjusted by multiple covariates. The risk of death, stroke, and acute kidney injury was particularly increased in patients with severe bleeding.CONCLUSION: Severe bleeding is rather uncommon in low-risk patients undergoing CABG, but it is associated with an increased risk of major adverse events. Prevention of excessive perioperative bleeding and patient blood management may improve the outcome of cardiac surgery also in low-risk patients.

KW - Aged

KW - Blood Transfusion

KW - Coronary Artery Bypass/adverse effects

KW - Europe/epidemiology

KW - Female

KW - Humans

KW - Incidence

KW - Male

KW - Middle Aged

KW - Postoperative Hemorrhage/diagnosis

KW - Prognosis

KW - Prospective Studies

KW - Registries

KW - Risk Factors

KW - Tertiary Care Centers

U2 - 10.1111/trf.13885

DO - 10.1111/trf.13885

M3 - SCORING: Journal article

C2 - 27774615

VL - 57

SP - 178

EP - 186

JO - TRANSFUSION

JF - TRANSFUSION

SN - 0041-1132

IS - 1

ER -