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Incidence and predictors of depression in non-demented primary care attenders aged 75 years and older: results from a 3-year follow-up study

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Incidence and predictors of depression in non-demented primary care attenders aged 75 years and older: results from a 3-year follow-up study. / Weyerer, Siegfried; Eifflaender-Gorfer, Sandra; Wiese, Birgitt; Luppa, Melanie; Pentzek, Michael; Bickel, Horst; Bachmann, Cadja; Scherer, Martin; Maier, Wolfgang; Riedel-Heller, Steffi G.

In: AGE AGEING, Vol. 42, No. 2, 01.03.2013, p. 173-80.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Weyerer, S, Eifflaender-Gorfer, S, Wiese, B, Luppa, M, Pentzek, M, Bickel, H, Bachmann, C, Scherer, M, Maier, W & Riedel-Heller, SG 2013, 'Incidence and predictors of depression in non-demented primary care attenders aged 75 years and older: results from a 3-year follow-up study', AGE AGEING, vol. 42, no. 2, pp. 173-80. https://doi.org/10.1093/ageing/afs184

APA

Weyerer, S., Eifflaender-Gorfer, S., Wiese, B., Luppa, M., Pentzek, M., Bickel, H., Bachmann, C., Scherer, M., Maier, W., & Riedel-Heller, S. G. (2013). Incidence and predictors of depression in non-demented primary care attenders aged 75 years and older: results from a 3-year follow-up study. AGE AGEING, 42(2), 173-80. https://doi.org/10.1093/ageing/afs184

Vancouver

Weyerer S, Eifflaender-Gorfer S, Wiese B, Luppa M, Pentzek M, Bickel H et al. Incidence and predictors of depression in non-demented primary care attenders aged 75 years and older: results from a 3-year follow-up study. AGE AGEING. 2013 Mar 1;42(2):173-80. https://doi.org/10.1093/ageing/afs184

Bibtex

@article{02a023b0cae648e0b7c2918ab9d83720,
title = "Incidence and predictors of depression in non-demented primary care attenders aged 75 years and older: results from a 3-year follow-up study",
abstract = "OBJECTIVE: to determine incidence and predictors of late-life depression.METHODS: this is a 3-year observational cohort study of 3,214 non-demented patients aged 75 and over completing three waves of assessment. The patients were recruited in 138 primary care practices in six urban areas in Germany. Depressive symptoms were measured at baseline, and 18 months and 36 months later using the GDS-15 Geriatric Depression Scale with a cut-off 0-5/6-15. Cox proportional hazard regression models were applied to examine predictors of incident depression, adjusting for sex, age, education, living situation, activities of daily living - and instrumental activities of daily living impairment, somatic comorbidity, alcohol consumption, smoking, mild cognitive impairment and apoE4 status.RESULTS: the incidence of depression was 36.8 (95% CI: 29.6-45.3) per 1,000 person-years in men and 46.0 (95% CI: 39.9-52.8) in women (sex difference P = 0.069). The incidence increased from 35.4 (95% CI: 29.7-41.9) per 1000 person-years between the ages of 75 and 79 to 75.2 (95% CI: 53.2-103.2) for subjects 85 years and older. After full adjustment for confounding variables, hazard ratios (HR) for incident depression were significantly higher for subjects 85 years and older (HR: 1.83, 95% CI: 1.24-2.70) and those with mobility impairment (HR: 2.53, 95% CI: 1.97-3.25), vision impairment (HR: 1.41, 95% CI: 1.04-1.91), mild cognitive impairment (HR: 1.52, 95% CI: 1.10-2.10), subjective memory impairment (HR: 1.33, 95% CI: 1.01-1.74) and current smoking (HR: 1.69, 95% CI: 1.13-2.53).CONCLUSIONS: the incidence of depression increased significantly with age. In designing prevention programmes, it is important to call more attention on functional impairment, cognitive impairment and smoking.",
keywords = "Age Factors, Aged, Aged, 80 and over, Aging, Comorbidity, Depression, Female, Follow-Up Studies, Geriatric Assessment, Germany, Humans, Incidence, Male, Memory Disorders, Mild Cognitive Impairment, Mobility Limitation, Multivariate Analysis, Predictive Value of Tests, Primary Health Care, Proportional Hazards Models, Psychiatric Status Rating Scales, Risk Assessment, Risk Factors, Sex Factors, Smoking, Time Factors, Vision Disorders",
author = "Siegfried Weyerer and Sandra Eifflaender-Gorfer and Birgitt Wiese and Melanie Luppa and Michael Pentzek and Horst Bickel and Cadja Bachmann and Martin Scherer and Wolfgang Maier and Riedel-Heller, {Steffi G}",
year = "2013",
month = mar,
day = "1",
doi = "10.1093/ageing/afs184",
language = "English",
volume = "42",
pages = "173--80",
journal = "AGE AGEING",
issn = "0002-0729",
publisher = "Oxford University Press",
number = "2",

}

RIS

TY - JOUR

T1 - Incidence and predictors of depression in non-demented primary care attenders aged 75 years and older: results from a 3-year follow-up study

AU - Weyerer, Siegfried

AU - Eifflaender-Gorfer, Sandra

AU - Wiese, Birgitt

AU - Luppa, Melanie

AU - Pentzek, Michael

AU - Bickel, Horst

AU - Bachmann, Cadja

AU - Scherer, Martin

AU - Maier, Wolfgang

AU - Riedel-Heller, Steffi G

PY - 2013/3/1

Y1 - 2013/3/1

N2 - OBJECTIVE: to determine incidence and predictors of late-life depression.METHODS: this is a 3-year observational cohort study of 3,214 non-demented patients aged 75 and over completing three waves of assessment. The patients were recruited in 138 primary care practices in six urban areas in Germany. Depressive symptoms were measured at baseline, and 18 months and 36 months later using the GDS-15 Geriatric Depression Scale with a cut-off 0-5/6-15. Cox proportional hazard regression models were applied to examine predictors of incident depression, adjusting for sex, age, education, living situation, activities of daily living - and instrumental activities of daily living impairment, somatic comorbidity, alcohol consumption, smoking, mild cognitive impairment and apoE4 status.RESULTS: the incidence of depression was 36.8 (95% CI: 29.6-45.3) per 1,000 person-years in men and 46.0 (95% CI: 39.9-52.8) in women (sex difference P = 0.069). The incidence increased from 35.4 (95% CI: 29.7-41.9) per 1000 person-years between the ages of 75 and 79 to 75.2 (95% CI: 53.2-103.2) for subjects 85 years and older. After full adjustment for confounding variables, hazard ratios (HR) for incident depression were significantly higher for subjects 85 years and older (HR: 1.83, 95% CI: 1.24-2.70) and those with mobility impairment (HR: 2.53, 95% CI: 1.97-3.25), vision impairment (HR: 1.41, 95% CI: 1.04-1.91), mild cognitive impairment (HR: 1.52, 95% CI: 1.10-2.10), subjective memory impairment (HR: 1.33, 95% CI: 1.01-1.74) and current smoking (HR: 1.69, 95% CI: 1.13-2.53).CONCLUSIONS: the incidence of depression increased significantly with age. In designing prevention programmes, it is important to call more attention on functional impairment, cognitive impairment and smoking.

AB - OBJECTIVE: to determine incidence and predictors of late-life depression.METHODS: this is a 3-year observational cohort study of 3,214 non-demented patients aged 75 and over completing three waves of assessment. The patients were recruited in 138 primary care practices in six urban areas in Germany. Depressive symptoms were measured at baseline, and 18 months and 36 months later using the GDS-15 Geriatric Depression Scale with a cut-off 0-5/6-15. Cox proportional hazard regression models were applied to examine predictors of incident depression, adjusting for sex, age, education, living situation, activities of daily living - and instrumental activities of daily living impairment, somatic comorbidity, alcohol consumption, smoking, mild cognitive impairment and apoE4 status.RESULTS: the incidence of depression was 36.8 (95% CI: 29.6-45.3) per 1,000 person-years in men and 46.0 (95% CI: 39.9-52.8) in women (sex difference P = 0.069). The incidence increased from 35.4 (95% CI: 29.7-41.9) per 1000 person-years between the ages of 75 and 79 to 75.2 (95% CI: 53.2-103.2) for subjects 85 years and older. After full adjustment for confounding variables, hazard ratios (HR) for incident depression were significantly higher for subjects 85 years and older (HR: 1.83, 95% CI: 1.24-2.70) and those with mobility impairment (HR: 2.53, 95% CI: 1.97-3.25), vision impairment (HR: 1.41, 95% CI: 1.04-1.91), mild cognitive impairment (HR: 1.52, 95% CI: 1.10-2.10), subjective memory impairment (HR: 1.33, 95% CI: 1.01-1.74) and current smoking (HR: 1.69, 95% CI: 1.13-2.53).CONCLUSIONS: the incidence of depression increased significantly with age. In designing prevention programmes, it is important to call more attention on functional impairment, cognitive impairment and smoking.

KW - Age Factors

KW - Aged

KW - Aged, 80 and over

KW - Aging

KW - Comorbidity

KW - Depression

KW - Female

KW - Follow-Up Studies

KW - Geriatric Assessment

KW - Germany

KW - Humans

KW - Incidence

KW - Male

KW - Memory Disorders

KW - Mild Cognitive Impairment

KW - Mobility Limitation

KW - Multivariate Analysis

KW - Predictive Value of Tests

KW - Primary Health Care

KW - Proportional Hazards Models

KW - Psychiatric Status Rating Scales

KW - Risk Assessment

KW - Risk Factors

KW - Sex Factors

KW - Smoking

KW - Time Factors

KW - Vision Disorders

U2 - 10.1093/ageing/afs184

DO - 10.1093/ageing/afs184

M3 - SCORING: Journal article

C2 - 23315829

VL - 42

SP - 173

EP - 180

JO - AGE AGEING

JF - AGE AGEING

SN - 0002-0729

IS - 2

ER -