Inactivation of yellow fever virus by WHO-recommended hand rub formulations and surface disinfectants
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Inactivation of yellow fever virus by WHO-recommended hand rub formulations and surface disinfectants. / Meister, Toni Luise; Frericks, Nicola; Kleinert, Robin D V; Rodríguez, Estefanía; Steinmann, Joerg; Todt, Daniel; Brown, Richard J P; Steinmann, Eike.
In: PLOS NEGLECT TROP D, Vol. 18, No. 6, e0012264, 06.2024.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Inactivation of yellow fever virus by WHO-recommended hand rub formulations and surface disinfectants
AU - Meister, Toni Luise
AU - Frericks, Nicola
AU - Kleinert, Robin D V
AU - Rodríguez, Estefanía
AU - Steinmann, Joerg
AU - Todt, Daniel
AU - Brown, Richard J P
AU - Steinmann, Eike
N1 - Copyright: © 2024 Meister et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PY - 2024/6
Y1 - 2024/6
N2 - Despite continued outbreaks of yellow fever virus (YFV) in endemic regions, data on its environmental stability or guidelines for its effective inactivation is limited. Here, we evaluated the susceptibility of the YFV 17D vaccine strain to inactivation by ethanol, 2-propanol, World Health Organization (WHO)-recommended hand rub formulations I and II, as well as surface disinfectants. In addition, two pathogenic strains were tested to compare inactivation kinetics by WHO-recommended hand rub formulations I and II. Furthermore, environmental stability of the vaccine strain was assessed. YFV 17D particles displayed infectivity half-life decay profiles of ~13 days at room temperature. Despite this extended environmental stability, YFV was efficiently inactivated by alcohols, WHO-recommended hand formulations, and four out of five tested surface disinfectants. These results are useful in defining disinfection protocols to prevent non-vector borne YFV transmission.
AB - Despite continued outbreaks of yellow fever virus (YFV) in endemic regions, data on its environmental stability or guidelines for its effective inactivation is limited. Here, we evaluated the susceptibility of the YFV 17D vaccine strain to inactivation by ethanol, 2-propanol, World Health Organization (WHO)-recommended hand rub formulations I and II, as well as surface disinfectants. In addition, two pathogenic strains were tested to compare inactivation kinetics by WHO-recommended hand rub formulations I and II. Furthermore, environmental stability of the vaccine strain was assessed. YFV 17D particles displayed infectivity half-life decay profiles of ~13 days at room temperature. Despite this extended environmental stability, YFV was efficiently inactivated by alcohols, WHO-recommended hand formulations, and four out of five tested surface disinfectants. These results are useful in defining disinfection protocols to prevent non-vector borne YFV transmission.
KW - Yellow fever virus/drug effects
KW - Disinfectants/pharmacology
KW - Virus Inactivation/drug effects
KW - Humans
KW - World Health Organization
KW - Yellow Fever/prevention & control
KW - Hand Disinfection/methods
KW - Animals
KW - Chlorocebus aethiops
U2 - 10.1371/journal.pntd.0012264
DO - 10.1371/journal.pntd.0012264
M3 - SCORING: Journal article
C2 - 38900788
VL - 18
JO - PLOS NEGLECT TROP D
JF - PLOS NEGLECT TROP D
SN - 1935-2735
IS - 6
M1 - e0012264
ER -
