In vivo roles of factor XII.
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In vivo roles of factor XII. / Renné, Thomas; Schmaier, Alvin H; Nickel, Katrin F; Blombäck, Margareta; Maas, Coen.
In: BLOOD, Vol. 120, No. 22, 22, 2012, p. 4296-4303.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - In vivo roles of factor XII.
AU - Renné, Thomas
AU - Schmaier, Alvin H
AU - Nickel, Katrin F
AU - Blombäck, Margareta
AU - Maas, Coen
PY - 2012
Y1 - 2012
N2 - Coagulation factor XII (FXII, Hageman factor, EC = 3.4.21.38) is the zymogen of the serine protease, factor XIIa (FXIIa). FXII is converted to FXIIa through autoactivation induced by "contact" to charged surfaces. FXIIa is of crucial importance for fibrin formation in vitro, but deficiency in the protease is not associated with excessive bleeding. For decades, FXII was considered to have no function for coagulation in vivo. Our laboratory developed the first murine knockout model of FXII. Consistent with their human counterparts, FXII(-/-) mice have a normal hemostatic capacity. However, thrombus formation in FXII(-/-) mice is largely defective, and the animals are protected from experimental cerebral ischemia and pulmonary embolism. This murine model has created new interest in FXII because it raises the possibility for safe anticoagulation, which targets thrombosis without influence on hemostasis. We recently have identified platelet polyphosphate (an inorganic polymer) and mast cell heparin as in vivo FXII activators with implications on the initiation of thrombosis and edema during hypersensitivity reactions. Independent of its protease activity, FXII exerts mitogenic activity with implications for angiogenesis. The goal of this review is to summarize the in vivo functions of FXII, with special focus to its functions in thrombosis and vascular biology.
AB - Coagulation factor XII (FXII, Hageman factor, EC = 3.4.21.38) is the zymogen of the serine protease, factor XIIa (FXIIa). FXII is converted to FXIIa through autoactivation induced by "contact" to charged surfaces. FXIIa is of crucial importance for fibrin formation in vitro, but deficiency in the protease is not associated with excessive bleeding. For decades, FXII was considered to have no function for coagulation in vivo. Our laboratory developed the first murine knockout model of FXII. Consistent with their human counterparts, FXII(-/-) mice have a normal hemostatic capacity. However, thrombus formation in FXII(-/-) mice is largely defective, and the animals are protected from experimental cerebral ischemia and pulmonary embolism. This murine model has created new interest in FXII because it raises the possibility for safe anticoagulation, which targets thrombosis without influence on hemostasis. We recently have identified platelet polyphosphate (an inorganic polymer) and mast cell heparin as in vivo FXII activators with implications on the initiation of thrombosis and edema during hypersensitivity reactions. Independent of its protease activity, FXII exerts mitogenic activity with implications for angiogenesis. The goal of this review is to summarize the in vivo functions of FXII, with special focus to its functions in thrombosis and vascular biology.
KW - Animals
KW - Humans
KW - Mice
KW - Mice, Knockout
KW - Models, Biological
KW - Blood Coagulation/genetics/physiology
KW - Blood Vessels/metabolism/physiology
KW - Factor XII/genetics/metabolism/physiology
KW - Hemostasis/genetics/physiology
KW - Inflammation/blood/etiology/genetics
KW - Thrombosis/blood/etiology/genetics
KW - Animals
KW - Humans
KW - Mice
KW - Mice, Knockout
KW - Models, Biological
KW - Blood Coagulation/genetics/physiology
KW - Blood Vessels/metabolism/physiology
KW - Factor XII/genetics/metabolism/physiology
KW - Hemostasis/genetics/physiology
KW - Inflammation/blood/etiology/genetics
KW - Thrombosis/blood/etiology/genetics
M3 - SCORING: Journal article
VL - 120
SP - 4296
EP - 4303
JO - BLOOD
JF - BLOOD
SN - 0006-4971
IS - 22
M1 - 22
ER -
