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In vivo phage display and vascular heterogeneity: implications for targeted medicine

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In vivo phage display and vascular heterogeneity: implications for targeted medicine. / Trepel, Martin; Arap, Wadih; Pasqualini, Renata.

In: CURR OPIN CHEM BIOL, Vol. 6, No. 3, 06.2002, p. 399-404.

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Harvard

Trepel, M, Arap, W & Pasqualini, R 2002, 'In vivo phage display and vascular heterogeneity: implications for targeted medicine', CURR OPIN CHEM BIOL, vol. 6, no. 3, pp. 399-404.

APA

Trepel, M., Arap, W., & Pasqualini, R. (2002). In vivo phage display and vascular heterogeneity: implications for targeted medicine. CURR OPIN CHEM BIOL, 6(3), 399-404.

Vancouver

Trepel M, Arap W, Pasqualini R. In vivo phage display and vascular heterogeneity: implications for targeted medicine. CURR OPIN CHEM BIOL. 2002 Jun;6(3):399-404.

Bibtex

@article{e5a2153954db4e47863ee97764245c20,
title = "In vivo phage display and vascular heterogeneity: implications for targeted medicine",
abstract = "The vascular endothelium expresses differential receptors depending on the functional state and tissue localization of its cells. A method to characterize this receptor heterogeneity with phage display random peptide libraries has been developed. Using this technology, several peptide ligands have been isolated that home to tissue-specific endothelial cell receptors following intravenous administration. Such peptide ligands, or antibodies directed against specific vascular receptors, can be used to target therapeutic compounds or imaging agents to endothelial cells in vitro and in vivo. Recent advances in the field include identification of novel endothelial receptors expressed differentially in normal and pathological conditions and the isolation of peptides or antibody ligands to such receptors in in vitro assays, in animal models and in a human patient. These milestones, which extend the 'functional map' of the vasculature, should lead to clinical applications in diseases such as cancer and other conditions that exhibit distinct vascular characteristics.",
keywords = "Endothelium, Vascular, Genetic Therapy, Humans, Ligands, Neovascularization, Physiologic, Peptide Library, Receptors, Cell Surface, Journal Article, Review",
author = "Martin Trepel and Wadih Arap and Renata Pasqualini",
year = "2002",
month = jun,
language = "English",
volume = "6",
pages = "399--404",
journal = "CURR OPIN CHEM BIOL",
issn = "1367-5931",
publisher = "Elsevier Limited",
number = "3",

}

RIS

TY - JOUR

T1 - In vivo phage display and vascular heterogeneity: implications for targeted medicine

AU - Trepel, Martin

AU - Arap, Wadih

AU - Pasqualini, Renata

PY - 2002/6

Y1 - 2002/6

N2 - The vascular endothelium expresses differential receptors depending on the functional state and tissue localization of its cells. A method to characterize this receptor heterogeneity with phage display random peptide libraries has been developed. Using this technology, several peptide ligands have been isolated that home to tissue-specific endothelial cell receptors following intravenous administration. Such peptide ligands, or antibodies directed against specific vascular receptors, can be used to target therapeutic compounds or imaging agents to endothelial cells in vitro and in vivo. Recent advances in the field include identification of novel endothelial receptors expressed differentially in normal and pathological conditions and the isolation of peptides or antibody ligands to such receptors in in vitro assays, in animal models and in a human patient. These milestones, which extend the 'functional map' of the vasculature, should lead to clinical applications in diseases such as cancer and other conditions that exhibit distinct vascular characteristics.

AB - The vascular endothelium expresses differential receptors depending on the functional state and tissue localization of its cells. A method to characterize this receptor heterogeneity with phage display random peptide libraries has been developed. Using this technology, several peptide ligands have been isolated that home to tissue-specific endothelial cell receptors following intravenous administration. Such peptide ligands, or antibodies directed against specific vascular receptors, can be used to target therapeutic compounds or imaging agents to endothelial cells in vitro and in vivo. Recent advances in the field include identification of novel endothelial receptors expressed differentially in normal and pathological conditions and the isolation of peptides or antibody ligands to such receptors in in vitro assays, in animal models and in a human patient. These milestones, which extend the 'functional map' of the vasculature, should lead to clinical applications in diseases such as cancer and other conditions that exhibit distinct vascular characteristics.

KW - Endothelium, Vascular

KW - Genetic Therapy

KW - Humans

KW - Ligands

KW - Neovascularization, Physiologic

KW - Peptide Library

KW - Receptors, Cell Surface

KW - Journal Article

KW - Review

M3 - SCORING: Review article

C2 - 12023122

VL - 6

SP - 399

EP - 404

JO - CURR OPIN CHEM BIOL

JF - CURR OPIN CHEM BIOL

SN - 1367-5931

IS - 3

ER -