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In vivo MRI measurement of fetal blood oxygen saturation in cardiac ventricles of fetal sheep: a feasibility study.

Standard

In vivo MRI measurement of fetal blood oxygen saturation in cardiac ventricles of fetal sheep: a feasibility study. / Wedegärtner, Ulrike; Kooijman, Hendrik; Yamamura, Jin; Frisch, Michael; Weber, Christoph; Buchert, Ralph; Huff, Anna; Hecher, Kurt; Adam, Gerhard.

In: MAGN RESON MED, Vol. 64, No. 1, 1, 2010, p. 32-41.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Wedegärtner, U, Kooijman, H, Yamamura, J, Frisch, M, Weber, C, Buchert, R, Huff, A, Hecher, K & Adam, G 2010, 'In vivo MRI measurement of fetal blood oxygen saturation in cardiac ventricles of fetal sheep: a feasibility study.', MAGN RESON MED, vol. 64, no. 1, 1, pp. 32-41. <http://www.ncbi.nlm.nih.gov/pubmed/20572133?dopt=Citation>

APA

Wedegärtner, U., Kooijman, H., Yamamura, J., Frisch, M., Weber, C., Buchert, R., Huff, A., Hecher, K., & Adam, G. (2010). In vivo MRI measurement of fetal blood oxygen saturation in cardiac ventricles of fetal sheep: a feasibility study. MAGN RESON MED, 64(1), 32-41. [1]. http://www.ncbi.nlm.nih.gov/pubmed/20572133?dopt=Citation

Vancouver

Wedegärtner U, Kooijman H, Yamamura J, Frisch M, Weber C, Buchert R et al. In vivo MRI measurement of fetal blood oxygen saturation in cardiac ventricles of fetal sheep: a feasibility study. MAGN RESON MED. 2010;64(1):32-41. 1.

Bibtex

@article{525c00f28efe45eba33276a65c815d5b,
title = "In vivo MRI measurement of fetal blood oxygen saturation in cardiac ventricles of fetal sheep: a feasibility study.",
abstract = "The purpose of this study was to assess the feasibility to determine fetal blood oxygen saturation (sO(2)) with T(2)-weighted MR sequences using a fetal sheep model. T(2) measurements were performed on a 1.5-T scanner using a T(2) preparation pulse in combination with a three-dimensional balanced steady-state free precession sequence repeated at different echo times. Eight sheep fetuses were examined during a control, hypoxic, and recovery phase to perform T(2)-weighted scans of the fetal blood in the heart. Signal intensities in the left and right ventricle were measured to calculate the MR blood sO(2). During each phase, fetal carotid artery sO(2) was directly measured and correlated with MR sO(2). A Bland-Altman plot was performed. Fetal carotid artery sO(2) was 69% sO(2) during control, 16% sO(2) during hypoxemia, and 67% sO(2) during recovery. Mean values of the MR sO(2) were 49% sO(2) and 40% sO(2) for control, 6% sO(2) and 3% sO(2) for hypoxemia, and 51% sO(2) and 43% sO(2) for recovery in left ventricle and right ventricle, respectively. Mean values of fetal carotid artery sO(2) and MR sO(2) were highly correlated (left ventricle: r = 0.87, right ventricle: r = 0.89). According to the Bland-Altman plot, MR sO(2) was lower compared to fetal carotid artery sO(2) (left ventricle: 15%, right ventricle: 20%). Based on our preliminary results, it seems to be possible to assess fetal sO(2) with MR oximetry.",
keywords = "Animals, Humans, Magnetic Resonance Imaging, Feasibility Studies, Fetal Blood metabolism, Fetal Heart radiography, Heart Ventricles metabolism, Models, Theoretical, Oxygen metabolism, Sheep, Animals, Humans, Magnetic Resonance Imaging, Feasibility Studies, Fetal Blood metabolism, Fetal Heart radiography, Heart Ventricles metabolism, Models, Theoretical, Oxygen metabolism, Sheep",
author = "Ulrike Wedeg{\"a}rtner and Hendrik Kooijman and Jin Yamamura and Michael Frisch and Christoph Weber and Ralph Buchert and Anna Huff and Kurt Hecher and Gerhard Adam",
year = "2010",
language = "Deutsch",
volume = "64",
pages = "32--41",
journal = "MAGN RESON MED",
issn = "0740-3194",
publisher = "John Wiley and Sons Inc.",
number = "1",

}

RIS

TY - JOUR

T1 - In vivo MRI measurement of fetal blood oxygen saturation in cardiac ventricles of fetal sheep: a feasibility study.

AU - Wedegärtner, Ulrike

AU - Kooijman, Hendrik

AU - Yamamura, Jin

AU - Frisch, Michael

AU - Weber, Christoph

AU - Buchert, Ralph

AU - Huff, Anna

AU - Hecher, Kurt

AU - Adam, Gerhard

PY - 2010

Y1 - 2010

N2 - The purpose of this study was to assess the feasibility to determine fetal blood oxygen saturation (sO(2)) with T(2)-weighted MR sequences using a fetal sheep model. T(2) measurements were performed on a 1.5-T scanner using a T(2) preparation pulse in combination with a three-dimensional balanced steady-state free precession sequence repeated at different echo times. Eight sheep fetuses were examined during a control, hypoxic, and recovery phase to perform T(2)-weighted scans of the fetal blood in the heart. Signal intensities in the left and right ventricle were measured to calculate the MR blood sO(2). During each phase, fetal carotid artery sO(2) was directly measured and correlated with MR sO(2). A Bland-Altman plot was performed. Fetal carotid artery sO(2) was 69% sO(2) during control, 16% sO(2) during hypoxemia, and 67% sO(2) during recovery. Mean values of the MR sO(2) were 49% sO(2) and 40% sO(2) for control, 6% sO(2) and 3% sO(2) for hypoxemia, and 51% sO(2) and 43% sO(2) for recovery in left ventricle and right ventricle, respectively. Mean values of fetal carotid artery sO(2) and MR sO(2) were highly correlated (left ventricle: r = 0.87, right ventricle: r = 0.89). According to the Bland-Altman plot, MR sO(2) was lower compared to fetal carotid artery sO(2) (left ventricle: 15%, right ventricle: 20%). Based on our preliminary results, it seems to be possible to assess fetal sO(2) with MR oximetry.

AB - The purpose of this study was to assess the feasibility to determine fetal blood oxygen saturation (sO(2)) with T(2)-weighted MR sequences using a fetal sheep model. T(2) measurements were performed on a 1.5-T scanner using a T(2) preparation pulse in combination with a three-dimensional balanced steady-state free precession sequence repeated at different echo times. Eight sheep fetuses were examined during a control, hypoxic, and recovery phase to perform T(2)-weighted scans of the fetal blood in the heart. Signal intensities in the left and right ventricle were measured to calculate the MR blood sO(2). During each phase, fetal carotid artery sO(2) was directly measured and correlated with MR sO(2). A Bland-Altman plot was performed. Fetal carotid artery sO(2) was 69% sO(2) during control, 16% sO(2) during hypoxemia, and 67% sO(2) during recovery. Mean values of the MR sO(2) were 49% sO(2) and 40% sO(2) for control, 6% sO(2) and 3% sO(2) for hypoxemia, and 51% sO(2) and 43% sO(2) for recovery in left ventricle and right ventricle, respectively. Mean values of fetal carotid artery sO(2) and MR sO(2) were highly correlated (left ventricle: r = 0.87, right ventricle: r = 0.89). According to the Bland-Altman plot, MR sO(2) was lower compared to fetal carotid artery sO(2) (left ventricle: 15%, right ventricle: 20%). Based on our preliminary results, it seems to be possible to assess fetal sO(2) with MR oximetry.

KW - Animals

KW - Humans

KW - Magnetic Resonance Imaging

KW - Feasibility Studies

KW - Fetal Blood metabolism

KW - Fetal Heart radiography

KW - Heart Ventricles metabolism

KW - Models, Theoretical

KW - Oxygen metabolism

KW - Sheep

KW - Animals

KW - Humans

KW - Magnetic Resonance Imaging

KW - Feasibility Studies

KW - Fetal Blood metabolism

KW - Fetal Heart radiography

KW - Heart Ventricles metabolism

KW - Models, Theoretical

KW - Oxygen metabolism

KW - Sheep

M3 - SCORING: Zeitschriftenaufsatz

VL - 64

SP - 32

EP - 41

JO - MAGN RESON MED

JF - MAGN RESON MED

SN - 0740-3194

IS - 1

M1 - 1

ER -