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In Vivo Models of HDV Infection: Is Humanizing NTCP Enough?

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In Vivo Models of HDV Infection: Is Humanizing NTCP Enough? / Giersch, Katja; Dandri, Maura.

In: VIRUSES-BASEL, Vol. 13, No. 4, 31.03.2021, p. 588.

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Harvard

Giersch, K & Dandri, M 2021, 'In Vivo Models of HDV Infection: Is Humanizing NTCP Enough?', VIRUSES-BASEL, vol. 13, no. 4, pp. 588. https://doi.org/10.3390/v13040588

APA

Giersch, K., & Dandri, M. (2021). In Vivo Models of HDV Infection: Is Humanizing NTCP Enough? VIRUSES-BASEL, 13(4), 588. https://doi.org/10.3390/v13040588

Vancouver

Giersch K, Dandri M. In Vivo Models of HDV Infection: Is Humanizing NTCP Enough? VIRUSES-BASEL. 2021 Mar 31;13(4):588. https://doi.org/10.3390/v13040588

Bibtex

@article{8912706ecafa490d805d8666e4cf7bde,
title = "In Vivo Models of HDV Infection: Is Humanizing NTCP Enough?",
abstract = "The discovery of sodium taurocholate co-transporting polypeptide (NTCP) as a hepatitis B (HBV) and delta virus (HDV) entry receptor has encouraged the development of new animal models of infection. This review provides an overview of the different in vivo models that are currently available to study HDV either in the absence or presence of HBV. By presenting new advances and remaining drawbacks, we will discuss human host factors which, in addition to NTCP, need to be investigated or identified to enable a persistent HDV infection in murine hepatocytes. Detailed knowledge on species-specific factors involved in HDV persistence also shall contribute to the development of therapeutic strategies.",
author = "Katja Giersch and Maura Dandri",
year = "2021",
month = mar,
day = "31",
doi = "10.3390/v13040588",
language = "English",
volume = "13",
pages = "588",
journal = "VIRUSES-BASEL",
issn = "1999-4915",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "4",

}

RIS

TY - JOUR

T1 - In Vivo Models of HDV Infection: Is Humanizing NTCP Enough?

AU - Giersch, Katja

AU - Dandri, Maura

PY - 2021/3/31

Y1 - 2021/3/31

N2 - The discovery of sodium taurocholate co-transporting polypeptide (NTCP) as a hepatitis B (HBV) and delta virus (HDV) entry receptor has encouraged the development of new animal models of infection. This review provides an overview of the different in vivo models that are currently available to study HDV either in the absence or presence of HBV. By presenting new advances and remaining drawbacks, we will discuss human host factors which, in addition to NTCP, need to be investigated or identified to enable a persistent HDV infection in murine hepatocytes. Detailed knowledge on species-specific factors involved in HDV persistence also shall contribute to the development of therapeutic strategies.

AB - The discovery of sodium taurocholate co-transporting polypeptide (NTCP) as a hepatitis B (HBV) and delta virus (HDV) entry receptor has encouraged the development of new animal models of infection. This review provides an overview of the different in vivo models that are currently available to study HDV either in the absence or presence of HBV. By presenting new advances and remaining drawbacks, we will discuss human host factors which, in addition to NTCP, need to be investigated or identified to enable a persistent HDV infection in murine hepatocytes. Detailed knowledge on species-specific factors involved in HDV persistence also shall contribute to the development of therapeutic strategies.

U2 - 10.3390/v13040588

DO - 10.3390/v13040588

M3 - SCORING: Review article

C2 - 33807170

VL - 13

SP - 588

JO - VIRUSES-BASEL

JF - VIRUSES-BASEL

SN - 1999-4915

IS - 4

ER -