In vivo liver visualizations with magnetic particle imaging based on the calibration measurement approach

Standard

In vivo liver visualizations with magnetic particle imaging based on the calibration measurement approach. / Dieckhoff, Jan; Kaul, Michael; Mummert, Tobias; Jung, Caroline; Salamon, Johannes; Adam, Gerhard; Knopp, Tobias; Ludwig, Frank; Balceris, Christoph; Ittrich, Harald.

In: PHYS MED BIOL, Vol. 62, No. 9, 07.05.2017, p. 3470-3482.

Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

Harvard

APA

Vancouver

Bibtex

@article{091035f10ba740c6a3ff854e62d2e41e,
title = "In vivo liver visualizations with magnetic particle imaging based on the calibration measurement approach",
abstract = "Magnetic particle imaging (MPI) facilitates the rapid determination of three-dimensional in vivo magnetic nanoparticle distributions. In this work, liver MPI following intravenous injections of ferucarbotran (Resovist{\textregistered}) was studied. The image reconstruction was based on a calibration measurement, the so called system function. The application of an enhanced system function sample reflecting the particle mobility and aggregation status of ferucarbotran resulted in significantly improved image reconstructions. The finding was supported by characterizations of different ferucarbotran compositions with the magnetorelaxometry and magnetic particle spectroscopy technique, for instance, ferucarbotran embedded in freeze-dried mannitol sugar exhibited similar results compared to harvested liver tissue after ferucarbotran injection. In addition, the combination of multiple shifted measurement patches for a joint reconstruction of the MPI data increased the covering of liver MPI on magnetic resonance images noticeably.",
author = "Jan Dieckhoff and Michael Kaul and Tobias Mummert and Caroline Jung and Johannes Salamon and Gerhard Adam and Tobias Knopp and Frank Ludwig and Christoph Balceris and Harald Ittrich",
note = "Copyright 2016 Institute of Physics and Engineering in Medicine.",
year = "2017",
month = may,
day = "7",
doi = "10.1088/1361-6560/aa562d",
language = "English",
volume = "62",
pages = "3470--3482",
journal = "PHYS MED BIOL",
issn = "0031-9155",
publisher = "IOP Publishing Ltd.",
number = "9",

}

RIS

TY - JOUR

T1 - In vivo liver visualizations with magnetic particle imaging based on the calibration measurement approach

AU - Dieckhoff, Jan

AU - Kaul, Michael

AU - Mummert, Tobias

AU - Jung, Caroline

AU - Salamon, Johannes

AU - Adam, Gerhard

AU - Knopp, Tobias

AU - Ludwig, Frank

AU - Balceris, Christoph

AU - Ittrich, Harald

N1 - Copyright 2016 Institute of Physics and Engineering in Medicine.

PY - 2017/5/7

Y1 - 2017/5/7

N2 - Magnetic particle imaging (MPI) facilitates the rapid determination of three-dimensional in vivo magnetic nanoparticle distributions. In this work, liver MPI following intravenous injections of ferucarbotran (Resovist®) was studied. The image reconstruction was based on a calibration measurement, the so called system function. The application of an enhanced system function sample reflecting the particle mobility and aggregation status of ferucarbotran resulted in significantly improved image reconstructions. The finding was supported by characterizations of different ferucarbotran compositions with the magnetorelaxometry and magnetic particle spectroscopy technique, for instance, ferucarbotran embedded in freeze-dried mannitol sugar exhibited similar results compared to harvested liver tissue after ferucarbotran injection. In addition, the combination of multiple shifted measurement patches for a joint reconstruction of the MPI data increased the covering of liver MPI on magnetic resonance images noticeably.

AB - Magnetic particle imaging (MPI) facilitates the rapid determination of three-dimensional in vivo magnetic nanoparticle distributions. In this work, liver MPI following intravenous injections of ferucarbotran (Resovist®) was studied. The image reconstruction was based on a calibration measurement, the so called system function. The application of an enhanced system function sample reflecting the particle mobility and aggregation status of ferucarbotran resulted in significantly improved image reconstructions. The finding was supported by characterizations of different ferucarbotran compositions with the magnetorelaxometry and magnetic particle spectroscopy technique, for instance, ferucarbotran embedded in freeze-dried mannitol sugar exhibited similar results compared to harvested liver tissue after ferucarbotran injection. In addition, the combination of multiple shifted measurement patches for a joint reconstruction of the MPI data increased the covering of liver MPI on magnetic resonance images noticeably.

U2 - 10.1088/1361-6560/aa562d

DO - 10.1088/1361-6560/aa562d

M3 - SCORING: Journal article

C2 - 28035904

VL - 62

SP - 3470

EP - 3482

JO - PHYS MED BIOL

JF - PHYS MED BIOL

SN - 0031-9155

IS - 9

ER -