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In vivo evidence for a functional role of both tumor necrosis factor (TNF) receptors and transmembrane TNF in experimental hepatitis.

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In vivo evidence for a functional role of both tumor necrosis factor (TNF) receptors and transmembrane TNF in experimental hepatitis. / Küsters, S; Tiegs, Gisa; Alexopoulou, L; Pasparakis, M; Douni, E; Künstle, G; Bluethmann, H; Wendel, A; Pfizenmaier, K; Kollias, G; Grell, M.

In: EUR J IMMUNOL, Vol. 27, No. 11, 11, 1997, p. 2870-2875.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Küsters, S, Tiegs, G, Alexopoulou, L, Pasparakis, M, Douni, E, Künstle, G, Bluethmann, H, Wendel, A, Pfizenmaier, K, Kollias, G & Grell, M 1997, 'In vivo evidence for a functional role of both tumor necrosis factor (TNF) receptors and transmembrane TNF in experimental hepatitis.', EUR J IMMUNOL, vol. 27, no. 11, 11, pp. 2870-2875. <http://www.ncbi.nlm.nih.gov/pubmed/9394812?dopt=Citation>

APA

Küsters, S., Tiegs, G., Alexopoulou, L., Pasparakis, M., Douni, E., Künstle, G., Bluethmann, H., Wendel, A., Pfizenmaier, K., Kollias, G., & Grell, M. (1997). In vivo evidence for a functional role of both tumor necrosis factor (TNF) receptors and transmembrane TNF in experimental hepatitis. EUR J IMMUNOL, 27(11), 2870-2875. [11]. http://www.ncbi.nlm.nih.gov/pubmed/9394812?dopt=Citation

Vancouver

Küsters S, Tiegs G, Alexopoulou L, Pasparakis M, Douni E, Künstle G et al. In vivo evidence for a functional role of both tumor necrosis factor (TNF) receptors and transmembrane TNF in experimental hepatitis. EUR J IMMUNOL. 1997;27(11):2870-2875. 11.

Bibtex

@article{e98867f3ef014a4d9229b0927e9360e2,
title = "In vivo evidence for a functional role of both tumor necrosis factor (TNF) receptors and transmembrane TNF in experimental hepatitis.",
abstract = "The significance of tumor necrosis factor receptor 1 (TNFR1) for TNF function in vivo is well documented, whereas the role of TNFR2 so far remains obscure. In a model of concanavalin A (Con A)-induced, CD4+ T cell-dependent experimental hepatitis in mice, in which TNF is a central mediator of apoptotic and necrotic liver damage, we now provide evidence for an essential in vivo function of TNFR2 in this pathophysiological process. We demonstrate that a cooperation of TNFR1 and TNFR2 is required for hepatotoxicity as mice deficient of either receptor were resistant against Con A. A significant role of TNFR2 for Con A-induced hepatitis is also shown by the enhanced sensitivity of transgenic mice overexpressing the human TNFR2. The ligand for cytotoxic signaling via both TNF receptors is the precursor of soluble TNF, i.e. transmembrane TNF. Indeed, transmembrane TNF is sufficient to mediate hepatic damage, as transgenic mice deficient in wild-type soluble TNF but expressing a mutated nonsecretable form of TNF developed inflammatory liver disease.",
keywords = "Animals, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Immunity, Innate, Antigens, CD/genetics/metabolism, Concanavalin A/toxicity, Mice, Inbred CBA, Receptors, Tumor Necrosis Factor, Type II, Receptors, Tumor Necrosis Factor, Type I, Hepatitis, Animal/chemically induced/genetics/*immunology, Interferon-gamma/biosynthesis/drug effects, Liver Failure, Acute/chemically induced/genetics/immunology, Membrane Proteins/immunology/metabolism/*physiology, Receptors, Tumor Necrosis Factor/genetics/metabolism/*physiology, Tumor Necrosis Factor-alpha/metabolism/*physiology, Animals, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Immunity, Innate, Antigens, CD/genetics/metabolism, Concanavalin A/toxicity, Mice, Inbred CBA, Receptors, Tumor Necrosis Factor, Type II, Receptors, Tumor Necrosis Factor, Type I, Hepatitis, Animal/chemically induced/genetics/*immunology, Interferon-gamma/biosynthesis/drug effects, Liver Failure, Acute/chemically induced/genetics/immunology, Membrane Proteins/immunology/metabolism/*physiology, Receptors, Tumor Necrosis Factor/genetics/metabolism/*physiology, Tumor Necrosis Factor-alpha/metabolism/*physiology",
author = "S K{\"u}sters and Gisa Tiegs and L Alexopoulou and M Pasparakis and E Douni and G K{\"u}nstle and H Bluethmann and A Wendel and K Pfizenmaier and G Kollias and M Grell",
year = "1997",
language = "English",
volume = "27",
pages = "2870--2875",
journal = "EUR J IMMUNOL",
issn = "0014-2980",
publisher = "Wiley-VCH Verlag GmbH",
number = "11",

}

RIS

TY - JOUR

T1 - In vivo evidence for a functional role of both tumor necrosis factor (TNF) receptors and transmembrane TNF in experimental hepatitis.

AU - Küsters, S

AU - Tiegs, Gisa

AU - Alexopoulou, L

AU - Pasparakis, M

AU - Douni, E

AU - Künstle, G

AU - Bluethmann, H

AU - Wendel, A

AU - Pfizenmaier, K

AU - Kollias, G

AU - Grell, M

PY - 1997

Y1 - 1997

N2 - The significance of tumor necrosis factor receptor 1 (TNFR1) for TNF function in vivo is well documented, whereas the role of TNFR2 so far remains obscure. In a model of concanavalin A (Con A)-induced, CD4+ T cell-dependent experimental hepatitis in mice, in which TNF is a central mediator of apoptotic and necrotic liver damage, we now provide evidence for an essential in vivo function of TNFR2 in this pathophysiological process. We demonstrate that a cooperation of TNFR1 and TNFR2 is required for hepatotoxicity as mice deficient of either receptor were resistant against Con A. A significant role of TNFR2 for Con A-induced hepatitis is also shown by the enhanced sensitivity of transgenic mice overexpressing the human TNFR2. The ligand for cytotoxic signaling via both TNF receptors is the precursor of soluble TNF, i.e. transmembrane TNF. Indeed, transmembrane TNF is sufficient to mediate hepatic damage, as transgenic mice deficient in wild-type soluble TNF but expressing a mutated nonsecretable form of TNF developed inflammatory liver disease.

AB - The significance of tumor necrosis factor receptor 1 (TNFR1) for TNF function in vivo is well documented, whereas the role of TNFR2 so far remains obscure. In a model of concanavalin A (Con A)-induced, CD4+ T cell-dependent experimental hepatitis in mice, in which TNF is a central mediator of apoptotic and necrotic liver damage, we now provide evidence for an essential in vivo function of TNFR2 in this pathophysiological process. We demonstrate that a cooperation of TNFR1 and TNFR2 is required for hepatotoxicity as mice deficient of either receptor were resistant against Con A. A significant role of TNFR2 for Con A-induced hepatitis is also shown by the enhanced sensitivity of transgenic mice overexpressing the human TNFR2. The ligand for cytotoxic signaling via both TNF receptors is the precursor of soluble TNF, i.e. transmembrane TNF. Indeed, transmembrane TNF is sufficient to mediate hepatic damage, as transgenic mice deficient in wild-type soluble TNF but expressing a mutated nonsecretable form of TNF developed inflammatory liver disease.

KW - Animals

KW - Male

KW - Mice

KW - Mice, Inbred C57BL

KW - Mice, Knockout

KW - Immunity, Innate

KW - Antigens, CD/genetics/metabolism

KW - Concanavalin A/toxicity

KW - Mice, Inbred CBA

KW - Receptors, Tumor Necrosis Factor, Type II

KW - Receptors, Tumor Necrosis Factor, Type I

KW - Hepatitis, Animal/chemically induced/genetics/immunology

KW - Interferon-gamma/biosynthesis/drug effects

KW - Liver Failure, Acute/chemically induced/genetics/immunology

KW - Membrane Proteins/immunology/metabolism/physiology

KW - Receptors, Tumor Necrosis Factor/genetics/metabolism/physiology

KW - Tumor Necrosis Factor-alpha/metabolism/physiology

KW - Animals

KW - Male

KW - Mice

KW - Mice, Inbred C57BL

KW - Mice, Knockout

KW - Immunity, Innate

KW - Antigens, CD/genetics/metabolism

KW - Concanavalin A/toxicity

KW - Mice, Inbred CBA

KW - Receptors, Tumor Necrosis Factor, Type II

KW - Receptors, Tumor Necrosis Factor, Type I

KW - Hepatitis, Animal/chemically induced/genetics/immunology

KW - Interferon-gamma/biosynthesis/drug effects

KW - Liver Failure, Acute/chemically induced/genetics/immunology

KW - Membrane Proteins/immunology/metabolism/physiology

KW - Receptors, Tumor Necrosis Factor/genetics/metabolism/physiology

KW - Tumor Necrosis Factor-alpha/metabolism/physiology

M3 - SCORING: Journal article

VL - 27

SP - 2870

EP - 2875

JO - EUR J IMMUNOL

JF - EUR J IMMUNOL

SN - 0014-2980

IS - 11

M1 - 11

ER -