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In vitro susceptibility to 19 agents other than β-lactams among third-generation cephalosporin-resistant Enterobacteriaceae recovered on hospital admission

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In vitro susceptibility to 19 agents other than β-lactams among third-generation cephalosporin-resistant Enterobacteriaceae recovered on hospital admission. / Mischnik, A; Baumert, P; Hamprecht, A; Rohde, A M; Peter, S; Feihl, S; Knobloch, J K.-M.; Gölz, H; Kola, A; Obermann, B; Querbach, C; Willmann, M; Gebhardt, F; Tacconelli, E; Gastmeier, P; Seifert, H; Kern, W V; DZIF-ATHOS Study Group .

In: J ANTIMICROB CHEMOTH, Vol. 72, No. 5, 05.05.2017, p. 1359-1363.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Mischnik, A, Baumert, P, Hamprecht, A, Rohde, AM, Peter, S, Feihl, S, Knobloch, JK-M, Gölz, H, Kola, A, Obermann, B, Querbach, C, Willmann, M, Gebhardt, F, Tacconelli, E, Gastmeier, P, Seifert, H, Kern, WV & DZIF-ATHOS Study Group 2017, 'In vitro susceptibility to 19 agents other than β-lactams among third-generation cephalosporin-resistant Enterobacteriaceae recovered on hospital admission', J ANTIMICROB CHEMOTH, vol. 72, no. 5, pp. 1359-1363. https://doi.org/10.1093/jac/dkw577

APA

Mischnik, A., Baumert, P., Hamprecht, A., Rohde, A. M., Peter, S., Feihl, S., Knobloch, J. K-M., Gölz, H., Kola, A., Obermann, B., Querbach, C., Willmann, M., Gebhardt, F., Tacconelli, E., Gastmeier, P., Seifert, H., Kern, W. V., & DZIF-ATHOS Study Group (2017). In vitro susceptibility to 19 agents other than β-lactams among third-generation cephalosporin-resistant Enterobacteriaceae recovered on hospital admission. J ANTIMICROB CHEMOTH, 72(5), 1359-1363. https://doi.org/10.1093/jac/dkw577

Vancouver

Mischnik A, Baumert P, Hamprecht A, Rohde AM, Peter S, Feihl S et al. In vitro susceptibility to 19 agents other than β-lactams among third-generation cephalosporin-resistant Enterobacteriaceae recovered on hospital admission. J ANTIMICROB CHEMOTH. 2017 May 5;72(5):1359-1363. https://doi.org/10.1093/jac/dkw577

Bibtex

@article{c8a66fb81ebd4e25b1b32bc5f9ed4fed,
title = "In vitro susceptibility to 19 agents other than β-lactams among third-generation cephalosporin-resistant Enterobacteriaceae recovered on hospital admission",
abstract = "OBJECTIVES: As part of the multicentre Antibiotic Therapy Optimisation Study, MIC values of 19 non-β-lactam agents were determined for third-generation cephalosporin-resistant Escherichia coli, Klebsiella species and Enterobacter species (3GCREB) isolates collected in German hospitals.METHODS: A total of 328 E. coli, 35 Klebsiella spp. (1 Klebsiella oxytoca and 34 Klebsiella pneumoniae) and 16 Enterobacter spp. (1 Enterobacter aerogenes and 15 Enterobacter cloacae) isolates were submitted to broth microdilution antimicrobial susceptibility testing with the MICRONAUT system. MICs of fluoroquinolones (levofloxacin and moxifloxacin), aminoglycosides (gentamicin, tobramycin, amikacin, streptomycin, neomycin and paromomycin), tetracyclines (tetracycline, minocycline and tigecycline), macrolides (erythromycin, clarithromycin and azithromycin) and miscellaneous agents [trimethoprim/sulfamethoxazole, chloramphenicol, nitrofurantoin, colistin and fosfomycin intravenous (iv)] were determined and reviewed against 2016 EUCAST breakpoints.RESULTS: The MIC of levofloxacin was >2 mg/L for 128 of 328 E. coli and 8 of 35 Klebsiella spp., but only 1 of 16 Enterobacter spp. Rates of resistance to trimethoprim/sulfamethoxazole were high (>70%), except for Enterobacter spp. Rates of resistance to colistin and fosfomycin iv were still low. About 20% of the tested isolates were resistant to chloramphenicol. Only 1 (of 328) E. coli isolate had an MIC of amikacin >16 mg/L and only 33 of 328 E. coli and 1 of 35 Klebsiella spp. had an MIC of tobramycin >4 mg/L, whereas average gentamicin MICs were in general more elevated. A tigecycline MIC >2 mg/L was only found for 1 of 16 Enterobacter spp., but in none of the E. coli or Klebsiella spp. isolates.CONCLUSIONS: Our study gives insight into previously unreported non-β-lactam MIC distributions of 3GCREB isolates.",
author = "A Mischnik and P Baumert and A Hamprecht and Rohde, {A M} and S Peter and S Feihl and Knobloch, {J K.-M.} and H G{\"o}lz and A Kola and B Obermann and C Querbach and M Willmann and F Gebhardt and E Tacconelli and P Gastmeier and H Seifert and Kern, {W V} and {DZIF-ATHOS Study Group}",
note = "{\textcopyright} The Author 2017. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please email: journals.permissions@oup.com.",
year = "2017",
month = may,
day = "5",
doi = "10.1093/jac/dkw577",
language = "English",
volume = "72",
pages = "1359--1363",
journal = "J ANTIMICROB CHEMOTH",
issn = "0305-7453",
publisher = "Oxford University Press",
number = "5",

}

RIS

TY - JOUR

T1 - In vitro susceptibility to 19 agents other than β-lactams among third-generation cephalosporin-resistant Enterobacteriaceae recovered on hospital admission

AU - Mischnik, A

AU - Baumert, P

AU - Hamprecht, A

AU - Rohde, A M

AU - Peter, S

AU - Feihl, S

AU - Knobloch, J K.-M.

AU - Gölz, H

AU - Kola, A

AU - Obermann, B

AU - Querbach, C

AU - Willmann, M

AU - Gebhardt, F

AU - Tacconelli, E

AU - Gastmeier, P

AU - Seifert, H

AU - Kern, W V

AU - DZIF-ATHOS Study Group

N1 - © The Author 2017. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

PY - 2017/5/5

Y1 - 2017/5/5

N2 - OBJECTIVES: As part of the multicentre Antibiotic Therapy Optimisation Study, MIC values of 19 non-β-lactam agents were determined for third-generation cephalosporin-resistant Escherichia coli, Klebsiella species and Enterobacter species (3GCREB) isolates collected in German hospitals.METHODS: A total of 328 E. coli, 35 Klebsiella spp. (1 Klebsiella oxytoca and 34 Klebsiella pneumoniae) and 16 Enterobacter spp. (1 Enterobacter aerogenes and 15 Enterobacter cloacae) isolates were submitted to broth microdilution antimicrobial susceptibility testing with the MICRONAUT system. MICs of fluoroquinolones (levofloxacin and moxifloxacin), aminoglycosides (gentamicin, tobramycin, amikacin, streptomycin, neomycin and paromomycin), tetracyclines (tetracycline, minocycline and tigecycline), macrolides (erythromycin, clarithromycin and azithromycin) and miscellaneous agents [trimethoprim/sulfamethoxazole, chloramphenicol, nitrofurantoin, colistin and fosfomycin intravenous (iv)] were determined and reviewed against 2016 EUCAST breakpoints.RESULTS: The MIC of levofloxacin was >2 mg/L for 128 of 328 E. coli and 8 of 35 Klebsiella spp., but only 1 of 16 Enterobacter spp. Rates of resistance to trimethoprim/sulfamethoxazole were high (>70%), except for Enterobacter spp. Rates of resistance to colistin and fosfomycin iv were still low. About 20% of the tested isolates were resistant to chloramphenicol. Only 1 (of 328) E. coli isolate had an MIC of amikacin >16 mg/L and only 33 of 328 E. coli and 1 of 35 Klebsiella spp. had an MIC of tobramycin >4 mg/L, whereas average gentamicin MICs were in general more elevated. A tigecycline MIC >2 mg/L was only found for 1 of 16 Enterobacter spp., but in none of the E. coli or Klebsiella spp. isolates.CONCLUSIONS: Our study gives insight into previously unreported non-β-lactam MIC distributions of 3GCREB isolates.

AB - OBJECTIVES: As part of the multicentre Antibiotic Therapy Optimisation Study, MIC values of 19 non-β-lactam agents were determined for third-generation cephalosporin-resistant Escherichia coli, Klebsiella species and Enterobacter species (3GCREB) isolates collected in German hospitals.METHODS: A total of 328 E. coli, 35 Klebsiella spp. (1 Klebsiella oxytoca and 34 Klebsiella pneumoniae) and 16 Enterobacter spp. (1 Enterobacter aerogenes and 15 Enterobacter cloacae) isolates were submitted to broth microdilution antimicrobial susceptibility testing with the MICRONAUT system. MICs of fluoroquinolones (levofloxacin and moxifloxacin), aminoglycosides (gentamicin, tobramycin, amikacin, streptomycin, neomycin and paromomycin), tetracyclines (tetracycline, minocycline and tigecycline), macrolides (erythromycin, clarithromycin and azithromycin) and miscellaneous agents [trimethoprim/sulfamethoxazole, chloramphenicol, nitrofurantoin, colistin and fosfomycin intravenous (iv)] were determined and reviewed against 2016 EUCAST breakpoints.RESULTS: The MIC of levofloxacin was >2 mg/L for 128 of 328 E. coli and 8 of 35 Klebsiella spp., but only 1 of 16 Enterobacter spp. Rates of resistance to trimethoprim/sulfamethoxazole were high (>70%), except for Enterobacter spp. Rates of resistance to colistin and fosfomycin iv were still low. About 20% of the tested isolates were resistant to chloramphenicol. Only 1 (of 328) E. coli isolate had an MIC of amikacin >16 mg/L and only 33 of 328 E. coli and 1 of 35 Klebsiella spp. had an MIC of tobramycin >4 mg/L, whereas average gentamicin MICs were in general more elevated. A tigecycline MIC >2 mg/L was only found for 1 of 16 Enterobacter spp., but in none of the E. coli or Klebsiella spp. isolates.CONCLUSIONS: Our study gives insight into previously unreported non-β-lactam MIC distributions of 3GCREB isolates.

U2 - 10.1093/jac/dkw577

DO - 10.1093/jac/dkw577

M3 - SCORING: Journal article

C2 - 28108677

VL - 72

SP - 1359

EP - 1363

JO - J ANTIMICROB CHEMOTH

JF - J ANTIMICROB CHEMOTH

SN - 0305-7453

IS - 5

ER -