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In Vitro Model for Studying of the Role of IGFBP6 Gene in Breast Cancer Metastasizing

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In Vitro Model for Studying of the Role of IGFBP6 Gene in Breast Cancer Metastasizing. / Nikulin, S V; Raigorodskaya, M P; Poloznikov, A A; Zakharova, G S; Schumacher, U; Wicklein, D; Stürken, C; Riecken, K; Fomicheva, K A; Alekseev, B Ya; Shkurnikov, M Yu.

In: B EXP BIOL MED+, Vol. 164, No. 5, 03.2018, p. 688-692.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Nikulin, SV, Raigorodskaya, MP, Poloznikov, AA, Zakharova, GS, Schumacher, U, Wicklein, D, Stürken, C, Riecken, K, Fomicheva, KA, Alekseev, BY & Shkurnikov, MY 2018, 'In Vitro Model for Studying of the Role of IGFBP6 Gene in Breast Cancer Metastasizing', B EXP BIOL MED+, vol. 164, no. 5, pp. 688-692. https://doi.org/10.1007/s10517-018-4060-7

APA

Nikulin, S. V., Raigorodskaya, M. P., Poloznikov, A. A., Zakharova, G. S., Schumacher, U., Wicklein, D., Stürken, C., Riecken, K., Fomicheva, K. A., Alekseev, B. Y., & Shkurnikov, M. Y. (2018). In Vitro Model for Studying of the Role of IGFBP6 Gene in Breast Cancer Metastasizing. B EXP BIOL MED+, 164(5), 688-692. https://doi.org/10.1007/s10517-018-4060-7

Vancouver

Nikulin SV, Raigorodskaya MP, Poloznikov AA, Zakharova GS, Schumacher U, Wicklein D et al. In Vitro Model for Studying of the Role of IGFBP6 Gene in Breast Cancer Metastasizing. B EXP BIOL MED+. 2018 Mar;164(5):688-692. https://doi.org/10.1007/s10517-018-4060-7

Bibtex

@article{7407b5f82c4f4a8fab2a7e369d5f47e7,
title = "In Vitro Model for Studying of the Role of IGFBP6 Gene in Breast Cancer Metastasizing",
abstract = "IGFBP6 gene plays an important role in the pathogenesis of breast cancer. In this work, we performed knockdown of IGFBP6 gene in MDA-MB-231 cells and obtained a stable cell line. Knockdown of IGFBP6 gene was confirmed by the real-time PCR. The influence of IGFBP6 gene on migration and proliferation of breast cancer cells was studied. Knockdown of IGFBP6 gene reduced migration activity of MDA-MB-231 cells and increased their proliferation rate. This in vitro cell model can be used for the further analysis of the role of IGFBP6 gene in the pathogenesis of breast cancer.",
keywords = "Journal Article",
author = "Nikulin, {S V} and Raigorodskaya, {M P} and Poloznikov, {A A} and Zakharova, {G S} and U Schumacher and D Wicklein and C St{\"u}rken and K Riecken and Fomicheva, {K A} and Alekseev, {B Ya} and Shkurnikov, {M Yu}",
year = "2018",
month = mar,
doi = "10.1007/s10517-018-4060-7",
language = "English",
volume = "164",
pages = "688--692",
journal = "B EXP BIOL MED+",
issn = "0007-4888",
publisher = "Springer New York",
number = "5",

}

RIS

TY - JOUR

T1 - In Vitro Model for Studying of the Role of IGFBP6 Gene in Breast Cancer Metastasizing

AU - Nikulin, S V

AU - Raigorodskaya, M P

AU - Poloznikov, A A

AU - Zakharova, G S

AU - Schumacher, U

AU - Wicklein, D

AU - Stürken, C

AU - Riecken, K

AU - Fomicheva, K A

AU - Alekseev, B Ya

AU - Shkurnikov, M Yu

PY - 2018/3

Y1 - 2018/3

N2 - IGFBP6 gene plays an important role in the pathogenesis of breast cancer. In this work, we performed knockdown of IGFBP6 gene in MDA-MB-231 cells and obtained a stable cell line. Knockdown of IGFBP6 gene was confirmed by the real-time PCR. The influence of IGFBP6 gene on migration and proliferation of breast cancer cells was studied. Knockdown of IGFBP6 gene reduced migration activity of MDA-MB-231 cells and increased their proliferation rate. This in vitro cell model can be used for the further analysis of the role of IGFBP6 gene in the pathogenesis of breast cancer.

AB - IGFBP6 gene plays an important role in the pathogenesis of breast cancer. In this work, we performed knockdown of IGFBP6 gene in MDA-MB-231 cells and obtained a stable cell line. Knockdown of IGFBP6 gene was confirmed by the real-time PCR. The influence of IGFBP6 gene on migration and proliferation of breast cancer cells was studied. Knockdown of IGFBP6 gene reduced migration activity of MDA-MB-231 cells and increased their proliferation rate. This in vitro cell model can be used for the further analysis of the role of IGFBP6 gene in the pathogenesis of breast cancer.

KW - Journal Article

U2 - 10.1007/s10517-018-4060-7

DO - 10.1007/s10517-018-4060-7

M3 - SCORING: Journal article

C2 - 29582205

VL - 164

SP - 688

EP - 692

JO - B EXP BIOL MED+

JF - B EXP BIOL MED+

SN - 0007-4888

IS - 5

ER -