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In vitro Anticancer Activities of Some Triterpene Glycosides from Holothurians of Cucumariidae, Stichopodidae, Psolidae, Holothuriidae and Synaptidae families

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In vitro Anticancer Activities of Some Triterpene Glycosides from Holothurians of Cucumariidae, Stichopodidae, Psolidae, Holothuriidae and Synaptidae families. / Fedorov, Sergey N; Dyshlovoy, Sergey; Kuzmich, Aleksandra S; Shubina, Larisa K; Avilov, Sergey A; Silchenko, Alexandra S; Stonik, Valentin A.

In: NAT PROD COMMUN, Vol. 11, No. 9, 2016, p. 1239-1242.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Fedorov, SN, Dyshlovoy, S, Kuzmich, AS, Shubina, LK, Avilov, SA, Silchenko, AS & Stonik, VA 2016, 'In vitro Anticancer Activities of Some Triterpene Glycosides from Holothurians of Cucumariidae, Stichopodidae, Psolidae, Holothuriidae and Synaptidae families', NAT PROD COMMUN, vol. 11, no. 9, pp. 1239-1242.

APA

Fedorov, S. N., Dyshlovoy, S., Kuzmich, A. S., Shubina, L. K., Avilov, S. A., Silchenko, A. S., & Stonik, V. A. (2016). In vitro Anticancer Activities of Some Triterpene Glycosides from Holothurians of Cucumariidae, Stichopodidae, Psolidae, Holothuriidae and Synaptidae families. NAT PROD COMMUN, 11(9), 1239-1242.

Vancouver

Fedorov SN, Dyshlovoy S, Kuzmich AS, Shubina LK, Avilov SA, Silchenko AS et al. In vitro Anticancer Activities of Some Triterpene Glycosides from Holothurians of Cucumariidae, Stichopodidae, Psolidae, Holothuriidae and Synaptidae families. NAT PROD COMMUN. 2016;11(9):1239-1242.

Bibtex

@article{55ef881192df4c03837cc9d86bc85a1e,
title = "In vitro Anticancer Activities of Some Triterpene Glycosides from Holothurians of Cucumariidae, Stichopodidae, Psolidae, Holothuriidae and Synaptidae families",
abstract = "Triterpene glycosides isolated from holothurians are natural products known to possess cytotoxic properties against cancer cells. However, their anticancer prophylactic activity has not been studied sufficiently. The anticancer prophylactic, cytotoxic, and pro-apoptotic properties of 18 triterpene glycosides, as well as their effects on the transcriptional activities of activator protein-1 (AP-1) and nuclear factor-kappa B (NF-kappa B), were examined using methods that included EGF-induced JB6 C141 P+ cell transformation in soft agar, flow cytometry, MTS assessment of cell viability, and a luciferase activity assay. The compounds inhibited EGF-induced neoplastic JB6 C141 P+ cell transformation in soft agar and caused apoptosis and necrosis of human HL-60 and THP-1 leukemia cells. AP-1 and NF-kappa B were involved in the cellular response to the treatment by the compounds. Conclusion: glycosides isolated from holothurians of Cucumariidae, Stichopodidae, Psolidae, Holothuriidae and Synaptidae families have potential for development as new antitumor agents and as instruments to study AP-1 and NF-kappa B.",
author = "Fedorov, {Sergey N} and Sergey Dyshlovoy and Kuzmich, {Aleksandra S} and Shubina, {Larisa K} and Avilov, {Sergey A} and Silchenko, {Alexandra S} and Stonik, {Valentin A}",
year = "2016",
language = "English",
volume = "11",
pages = "1239--1242",
journal = "NAT PROD COMMUN",
issn = "1934-578X",
publisher = "Natural Product Communications",
number = "9",

}

RIS

TY - JOUR

T1 - In vitro Anticancer Activities of Some Triterpene Glycosides from Holothurians of Cucumariidae, Stichopodidae, Psolidae, Holothuriidae and Synaptidae families

AU - Fedorov, Sergey N

AU - Dyshlovoy, Sergey

AU - Kuzmich, Aleksandra S

AU - Shubina, Larisa K

AU - Avilov, Sergey A

AU - Silchenko, Alexandra S

AU - Stonik, Valentin A

PY - 2016

Y1 - 2016

N2 - Triterpene glycosides isolated from holothurians are natural products known to possess cytotoxic properties against cancer cells. However, their anticancer prophylactic activity has not been studied sufficiently. The anticancer prophylactic, cytotoxic, and pro-apoptotic properties of 18 triterpene glycosides, as well as their effects on the transcriptional activities of activator protein-1 (AP-1) and nuclear factor-kappa B (NF-kappa B), were examined using methods that included EGF-induced JB6 C141 P+ cell transformation in soft agar, flow cytometry, MTS assessment of cell viability, and a luciferase activity assay. The compounds inhibited EGF-induced neoplastic JB6 C141 P+ cell transformation in soft agar and caused apoptosis and necrosis of human HL-60 and THP-1 leukemia cells. AP-1 and NF-kappa B were involved in the cellular response to the treatment by the compounds. Conclusion: glycosides isolated from holothurians of Cucumariidae, Stichopodidae, Psolidae, Holothuriidae and Synaptidae families have potential for development as new antitumor agents and as instruments to study AP-1 and NF-kappa B.

AB - Triterpene glycosides isolated from holothurians are natural products known to possess cytotoxic properties against cancer cells. However, their anticancer prophylactic activity has not been studied sufficiently. The anticancer prophylactic, cytotoxic, and pro-apoptotic properties of 18 triterpene glycosides, as well as their effects on the transcriptional activities of activator protein-1 (AP-1) and nuclear factor-kappa B (NF-kappa B), were examined using methods that included EGF-induced JB6 C141 P+ cell transformation in soft agar, flow cytometry, MTS assessment of cell viability, and a luciferase activity assay. The compounds inhibited EGF-induced neoplastic JB6 C141 P+ cell transformation in soft agar and caused apoptosis and necrosis of human HL-60 and THP-1 leukemia cells. AP-1 and NF-kappa B were involved in the cellular response to the treatment by the compounds. Conclusion: glycosides isolated from holothurians of Cucumariidae, Stichopodidae, Psolidae, Holothuriidae and Synaptidae families have potential for development as new antitumor agents and as instruments to study AP-1 and NF-kappa B.

M3 - SCORING: Journal article

VL - 11

SP - 1239

EP - 1242

JO - NAT PROD COMMUN

JF - NAT PROD COMMUN

SN - 1934-578X

IS - 9

ER -