In contrast to specific B cells, human basophils are unaffected by the toxic activity of an allergen toxin due to lack of internalization of immunoglobulin E-bound allergen.
Related Research units
Abstract
Specific immunotherapy is the only curative therapy for type I allergies and the alarming increase in allergy prevalence emphasizes the need for additional/alternative strategies for curative treatment. Allergen toxins (AT), fusion products of an allergen with an apoptosis inducing cytotoxin, are a new kind of immunotoxin.
Bibliographical data
| Original language | English |
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| Article number | 4 |
| ISSN | 0954-7894 |
| Publication status | Published - 2006 |
| pubmed | 16630160 |
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