In and out of control brain mechanisms linking fluency of action selection to self-agency in patients with schizophrenia

Martin Voss; Valérian Chambon; Dorit Wenke; Simone Kühn; Patrick Haggard

doi:10.1093/brain/awx136

In and out of control brain mechanisms linking fluency of action selection to self-agency in patients with schizophrenia

Standard

In and out of control brain mechanisms linking fluency of action selection to self-agency in patients with schizophrenia. / Voss, Martin; Chambon, Valérian; Wenke, Dorit; Kühn, Simone; Haggard, Patrick.

In: BRAIN, Vol. 140, No. 8, 01.08.2017, p. 2226-2239.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Voss, M, Chambon, V, Wenke, D, Kühn, S & Haggard, P 2017, 'In and out of control brain mechanisms linking fluency of action selection to self-agency in patients with schizophrenia', BRAIN, vol. 140, no. 8, pp. 2226-2239. https://doi.org/10.1093/brain/awx136

APA

Voss, M., Chambon, V., Wenke, D., Kühn, S., & Haggard, P. (2017). In and out of control brain mechanisms linking fluency of action selection to self-agency in patients with schizophrenia. BRAIN, 140(8), 2226-2239. https://doi.org/10.1093/brain/awx136

Vancouver

Voss M, Chambon V, Wenke D, Kühn S, Haggard P. In and out of control brain mechanisms linking fluency of action selection to self-agency in patients with schizophrenia. BRAIN. 2017 Aug 1;140(8):2226-2239. https://doi.org/10.1093/brain/awx136

Bibtex

@article{e34252e9946a4f609503661e3f7f5ac8,

title = "In and out of control brain mechanisms linking fluency of action selection to self-agency in patients with schizophrenia",

abstract = "Sense of agency refers to the feeling of control over one's actions, and their consequences. It involves both predictive processes linked to action control, and retrospective 'sense-making' causal inferences. Schizophrenia has been associated with impaired predictive processing, but the underlying mechanisms that impair patients' sense of agency remain unclear. We introduce a new 'prospective' aspect of agency and show that subliminally priming an action not only influences response times, but also influences reported sense of agency over subsequent action outcomes. This effect of priming was associated with altered connectivity between frontal areas and the angular gyrus. The effects on response times and on frontal action selection mechanisms were similar in patients with schizophrenia and in healthy volunteers. However, patients showed no effects of priming on sense of agency, no priming-related activation of angular gyrus, and no priming-related changes in fronto-parietal connectivity. We suggest angular gyrus activation reflects the experiences of agency, or non-agency, in part by processing action selection signals generated in the frontal lobes. The altered action awareness that characterizes schizophrenia may be due to impaired communication between these areas.",

keywords = "Adult, Case-Control Studies, Choice Behavior, Female, Functional Neuroimaging, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Parietal Lobe, Photic Stimulation, Prefrontal Cortex, Reaction Time, Repetition Priming, Schizophrenia, Schizophrenic Psychology, Self-Control, Young Adult, Journal Article",

author = "Martin Voss and Val{\'e}rian Chambon and Dorit Wenke and Simone K{\"u}hn and Patrick Haggard",

note = "{\textcopyright} The Author (2017). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please email: journals.permissions@oup.com.",

year = "2017",

month = aug,

day = "1",

doi = "10.1093/brain/awx136",

language = "English",

volume = "140",

pages = "2226--2239",

journal = "BRAIN",

issn = "0006-8950",

publisher = "Oxford University Press",

number = "8",

}

RIS

TY - JOUR

T1 - In and out of control brain mechanisms linking fluency of action selection to self-agency in patients with schizophrenia

AU - Voss, Martin

AU - Chambon, Valérian

AU - Wenke, Dorit

AU - Kühn, Simone

AU - Haggard, Patrick

PY - 2017/8/1

Y1 - 2017/8/1

N2 - Sense of agency refers to the feeling of control over one's actions, and their consequences. It involves both predictive processes linked to action control, and retrospective 'sense-making' causal inferences. Schizophrenia has been associated with impaired predictive processing, but the underlying mechanisms that impair patients' sense of agency remain unclear. We introduce a new 'prospective' aspect of agency and show that subliminally priming an action not only influences response times, but also influences reported sense of agency over subsequent action outcomes. This effect of priming was associated with altered connectivity between frontal areas and the angular gyrus. The effects on response times and on frontal action selection mechanisms were similar in patients with schizophrenia and in healthy volunteers. However, patients showed no effects of priming on sense of agency, no priming-related activation of angular gyrus, and no priming-related changes in fronto-parietal connectivity. We suggest angular gyrus activation reflects the experiences of agency, or non-agency, in part by processing action selection signals generated in the frontal lobes. The altered action awareness that characterizes schizophrenia may be due to impaired communication between these areas.

AB - Sense of agency refers to the feeling of control over one's actions, and their consequences. It involves both predictive processes linked to action control, and retrospective 'sense-making' causal inferences. Schizophrenia has been associated with impaired predictive processing, but the underlying mechanisms that impair patients' sense of agency remain unclear. We introduce a new 'prospective' aspect of agency and show that subliminally priming an action not only influences response times, but also influences reported sense of agency over subsequent action outcomes. This effect of priming was associated with altered connectivity between frontal areas and the angular gyrus. The effects on response times and on frontal action selection mechanisms were similar in patients with schizophrenia and in healthy volunteers. However, patients showed no effects of priming on sense of agency, no priming-related activation of angular gyrus, and no priming-related changes in fronto-parietal connectivity. We suggest angular gyrus activation reflects the experiences of agency, or non-agency, in part by processing action selection signals generated in the frontal lobes. The altered action awareness that characterizes schizophrenia may be due to impaired communication between these areas.

KW - Adult

KW - Case-Control Studies

KW - Choice Behavior

KW - Female

KW - Functional Neuroimaging

KW - Humans

KW - Magnetic Resonance Imaging

KW - Male

KW - Middle Aged

KW - Parietal Lobe

KW - Photic Stimulation

KW - Prefrontal Cortex

KW - Reaction Time

KW - Repetition Priming

KW - Schizophrenia

KW - Schizophrenic Psychology

KW - Self-Control

KW - Young Adult

KW - Journal Article

U2 - 10.1093/brain/awx136

DO - 10.1093/brain/awx136

M3 - SCORING: Journal article

C2 - 28899009

VL - 140

SP - 2226

EP - 2239

JO - BRAIN

JF - BRAIN

SN - 0006-8950

IS - 8

ER -