Improved detection of alcohol consumption using the novel marker phosphatidylethanol in the transplant setting: results of a prospective study
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Improved detection of alcohol consumption using the novel marker phosphatidylethanol in the transplant setting: results of a prospective study. / Andresen-Streichert, Hilke; Beres, Yannick; Weinmann, Wolfgang; Schröck, Alexandra; Müller, Alexander; Skopp, Gisela; Pischke, Sven; Vettorazzi, Eik; Lohse, Ansgar; Nashan, Björn; Sterneck, Martina.
In: TRANSPL INT, Vol. 30, No. 6, 06.2017, p. 611-620.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Improved detection of alcohol consumption using the novel marker phosphatidylethanol in the transplant setting: results of a prospective study
AU - Andresen-Streichert, Hilke
AU - Beres, Yannick
AU - Weinmann, Wolfgang
AU - Schröck, Alexandra
AU - Müller, Alexander
AU - Skopp, Gisela
AU - Pischke, Sven
AU - Vettorazzi, Eik
AU - Lohse, Ansgar
AU - Nashan, Björn
AU - Sterneck, Martina
N1 - © 2017 Steunstichting ESOT.
PY - 2017/6
Y1 - 2017/6
N2 - Phosphatidylethanol (PEth) is a new, highly specific alcohol marker. The aim of this study was to assess its diagnostic value in the liver transplant setting. In 51 pre- and 61 post-transplant patients with underlying alcoholic liver disease PEth, ethanol, methanol, carbohydrate-deficient transferrin (CDT), and ethyl glucuronide in urine (uEtG) and hair (hEtG) were tested and compared with patients' questionnaire reports. Twenty-eight (25%) patients tested positive for at least one alcohol marker. PEth alone revealed alcohol consumption in 18% of patients. With respect to detection of alcohol intake in the preceding week, PEth showed a 100% sensitivity. PEth testing was more sensitive than the determination of ethanol, methanol, CDT or uEtG alone [sensitivity 25% (confidence interval (CI) 95%, 7-52%), 25% (7-52%), 21% (6-45%) and 71% (41-91%), respectively], or ethanol, methanol and uEtG taken in combination with 73% (45-92%). Specificity of all markers was 92% or higher. Additional testing of hEtG revealed alcohol consumption in seven patients, not being positive for any other marker. Phosphatidylethanol was a highly specific and sensitive marker for detection of recent alcohol consumption in pre- and post-transplant patients. The additional determination of hEtG was useful in disclosing alcohol consumption 3-6 months retrospectively.
AB - Phosphatidylethanol (PEth) is a new, highly specific alcohol marker. The aim of this study was to assess its diagnostic value in the liver transplant setting. In 51 pre- and 61 post-transplant patients with underlying alcoholic liver disease PEth, ethanol, methanol, carbohydrate-deficient transferrin (CDT), and ethyl glucuronide in urine (uEtG) and hair (hEtG) were tested and compared with patients' questionnaire reports. Twenty-eight (25%) patients tested positive for at least one alcohol marker. PEth alone revealed alcohol consumption in 18% of patients. With respect to detection of alcohol intake in the preceding week, PEth showed a 100% sensitivity. PEth testing was more sensitive than the determination of ethanol, methanol, CDT or uEtG alone [sensitivity 25% (confidence interval (CI) 95%, 7-52%), 25% (7-52%), 21% (6-45%) and 71% (41-91%), respectively], or ethanol, methanol and uEtG taken in combination with 73% (45-92%). Specificity of all markers was 92% or higher. Additional testing of hEtG revealed alcohol consumption in seven patients, not being positive for any other marker. Phosphatidylethanol was a highly specific and sensitive marker for detection of recent alcohol consumption in pre- and post-transplant patients. The additional determination of hEtG was useful in disclosing alcohol consumption 3-6 months retrospectively.
KW - Journal Article
U2 - 10.1111/tri.12949
DO - 10.1111/tri.12949
M3 - SCORING: Journal article
C2 - 28295675
VL - 30
SP - 611
EP - 620
JO - TRANSPL INT
JF - TRANSPL INT
SN - 0934-0874
IS - 6
ER -
