Importance of altered glycoprotein-bound N- and O-glycans for epithelial-to-mesenchymal transition and adhesion of cancer cells

Tobias Lange; Timur R Samatov; Alexander G Tonevitsky; Udo Schumacher

doi:10.1016/j.carres.2014.01.010

Importance of altered glycoprotein-bound N- and O-glycans for epithelial-to-mesenchymal transition and adhesion of cancer cells

Standard

Importance of altered glycoprotein-bound N- and O-glycans for epithelial-to-mesenchymal transition and adhesion of cancer cells. / Lange, Tobias; Samatov, Timur R; Tonevitsky, Alexander G; Schumacher, Udo.

In: CARBOHYD RES, Vol. 389, 07.05.2014, p. 39-45.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Lange, T, Samatov, TR, Tonevitsky, AG & Schumacher, U 2014, 'Importance of altered glycoprotein-bound N- and O-glycans for epithelial-to-mesenchymal transition and adhesion of cancer cells', CARBOHYD RES, vol. 389, pp. 39-45. https://doi.org/10.1016/j.carres.2014.01.010

APA

Lange, T., Samatov, T. R., Tonevitsky, A. G., & Schumacher, U. (2014). Importance of altered glycoprotein-bound N- and O-glycans for epithelial-to-mesenchymal transition and adhesion of cancer cells. CARBOHYD RES, 389, 39-45. https://doi.org/10.1016/j.carres.2014.01.010

Vancouver

Lange T, Samatov TR, Tonevitsky AG, Schumacher U. Importance of altered glycoprotein-bound N- and O-glycans for epithelial-to-mesenchymal transition and adhesion of cancer cells. CARBOHYD RES. 2014 May 7;389:39-45. https://doi.org/10.1016/j.carres.2014.01.010

Bibtex

@article{6f899c3f94cb4ab1ba7195a599dde19c,

title = "Importance of altered glycoprotein-bound N- and O-glycans for epithelial-to-mesenchymal transition and adhesion of cancer cells",

abstract = "Aberrant glycosylation of cell surface glycoproteins acquired during malignant progression is a common characteristic of human cancer cells. Several biological processes and molecular mechanisms relevant for tumour progression are accompanied by altered mRNA expression levels of certain glycosyltransferases resulting in unusual ratios of common glycoconjugates present in a cancer cell's glycocalyx or even in the development of unusual, cancer-characterizing carbohydrates. This mini-review aims to give a concise overview on the current knowledge of the functional relevance of altered O- and N-glycans during two critical steps of tumour progression: (I) epithelial-to-mesenchymal transition of primary tumour cells during intravasation and (II) adhesion of circulating tumour cells towards the vascular wall during extravasation at a distant metastatic site. Characteristic lectin binding patterns reflecting these glycosylation changes and the resulting prognostic impact of certain lectin binding sites in different neoplasias are reviewed as well.",

author = "Tobias Lange and Samatov, {Timur R} and Tonevitsky, {Alexander G} and Udo Schumacher",

year = "2014",

month = may,

day = "7",

doi = "10.1016/j.carres.2014.01.010",

language = "English",

volume = "389",

pages = "39--45",

journal = "CARBOHYD RES",

issn = "0008-6215",

publisher = "Elsevier BV",

}

RIS

TY - JOUR

T1 - Importance of altered glycoprotein-bound N- and O-glycans for epithelial-to-mesenchymal transition and adhesion of cancer cells

AU - Lange, Tobias

AU - Samatov, Timur R

AU - Tonevitsky, Alexander G

AU - Schumacher, Udo

PY - 2014/5/7

Y1 - 2014/5/7

N2 - Aberrant glycosylation of cell surface glycoproteins acquired during malignant progression is a common characteristic of human cancer cells. Several biological processes and molecular mechanisms relevant for tumour progression are accompanied by altered mRNA expression levels of certain glycosyltransferases resulting in unusual ratios of common glycoconjugates present in a cancer cell's glycocalyx or even in the development of unusual, cancer-characterizing carbohydrates. This mini-review aims to give a concise overview on the current knowledge of the functional relevance of altered O- and N-glycans during two critical steps of tumour progression: (I) epithelial-to-mesenchymal transition of primary tumour cells during intravasation and (II) adhesion of circulating tumour cells towards the vascular wall during extravasation at a distant metastatic site. Characteristic lectin binding patterns reflecting these glycosylation changes and the resulting prognostic impact of certain lectin binding sites in different neoplasias are reviewed as well.

AB - Aberrant glycosylation of cell surface glycoproteins acquired during malignant progression is a common characteristic of human cancer cells. Several biological processes and molecular mechanisms relevant for tumour progression are accompanied by altered mRNA expression levels of certain glycosyltransferases resulting in unusual ratios of common glycoconjugates present in a cancer cell's glycocalyx or even in the development of unusual, cancer-characterizing carbohydrates. This mini-review aims to give a concise overview on the current knowledge of the functional relevance of altered O- and N-glycans during two critical steps of tumour progression: (I) epithelial-to-mesenchymal transition of primary tumour cells during intravasation and (II) adhesion of circulating tumour cells towards the vascular wall during extravasation at a distant metastatic site. Characteristic lectin binding patterns reflecting these glycosylation changes and the resulting prognostic impact of certain lectin binding sites in different neoplasias are reviewed as well.

U2 - 10.1016/j.carres.2014.01.010

DO - 10.1016/j.carres.2014.01.010

M3 - SCORING: Journal article

C2 - 24491280

VL - 389

SP - 39

EP - 45

JO - CARBOHYD RES

JF - CARBOHYD RES

SN - 0008-6215

ER -