Research ExplorerPublicationsImpaired negative selection of T cells in Hodgkin's disease ...

Impaired negative selection of T cells in Hodgkin's disease antigen CD30-deficient mice

Standard

Impaired negative selection of T cells in Hodgkin's disease antigen CD30-deficient mice. / Amakawa, R; Hakem, A; Kundig, T M; Matsuyama, T; Simard, J J; Timms, E; Wakeham, A; Mittrücker, Hans-Willi; Griesser, H; Takimoto, H; Schmits, R; Shahinian, A; Ohashi, P; Penninger, J M; Mak, T W; Mittrücker, Hans-Willi.

In: CELL, Vol. 84, No. 4, 23.02.1996, p. 551-62.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Amakawa, R, Hakem, A, Kundig, TM, Matsuyama, T, Simard, JJ, Timms, E, Wakeham, A, Mittrücker, H-W, Griesser, H, Takimoto, H, Schmits, R, Shahinian, A, Ohashi, P, Penninger, JM, Mak, TW & Mittrücker, H-W 1996, 'Impaired negative selection of T cells in Hodgkin's disease antigen CD30-deficient mice', CELL, vol. 84, no. 4, pp. 551-62.

APA

Amakawa, R., Hakem, A., Kundig, T. M., Matsuyama, T., Simard, J. J., Timms, E., Wakeham, A., Mittrücker, H-W., Griesser, H., Takimoto, H., Schmits, R., Shahinian, A., Ohashi, P., Penninger, J. M., Mak, T. W., & Mittrücker, H-W. (1996). Impaired negative selection of T cells in Hodgkin's disease antigen CD30-deficient mice. CELL, 84(4), 551-62.

Vancouver

Amakawa R, Hakem A, Kundig TM, Matsuyama T, Simard JJ, Timms E et al. Impaired negative selection of T cells in Hodgkin's disease antigen CD30-deficient mice. CELL. 1996 Feb 23;84(4):551-62.

Bibtex

@article{ee5db885e21f4f25a826e1e4b9240308,
title = "Impaired negative selection of T cells in Hodgkin's disease antigen CD30-deficient mice",
abstract = "CD30 is found on Reed-Sternberg cells of Hodgkin's disease and on a variety of non-Hodgkin's lymphoma cells and is up-regulated on cells after Epstein-Barr virus, human T cell leukemia virus, and HIV infections. We report here that the thymus in CD30-deficient mice contains elevated numbers of thymocytes. Activation-induced death of thymocytes after CD3 cross-linking is impaired both in vitro and in vivo. Breeding the CD30 mutation separately into alpha beta TCR-or gamma delta TCR-transgenic mice revealed a gross defect in negative but not positive selection. Thus, like TNF-receptors and Fas/Apo-1, the CD30 receptor is involved in cell death signaling. It is also an important coreceptor that participates in thymic deletion.",
keywords = "Animals, Antigens, CD30, B-Lymphocytes, Base Sequence, Cell Death, Cell Differentiation, Cell Separation, Gene Deletion, Gene Expression, Hodgkin Disease, Lymph Nodes, Male, Mice, Mice, Mutant Strains, Molecular Sequence Data, Receptors, Antigen, T-Cell, alpha-beta, Receptors, Antigen, T-Cell, gamma-delta, Signal Transduction, Superantigens, T-Lymphocytes, Thymus Gland",
author = "R Amakawa and A Hakem and Kundig, {T M} and T Matsuyama and Simard, {J J} and E Timms and A Wakeham and Hans-Willi Mittr{\"u}cker and H Griesser and H Takimoto and R Schmits and A Shahinian and P Ohashi and Penninger, {J M} and Mak, {T W} and Hans-Willi Mittr{\"u}cker",
year = "1996",
month = feb,
day = "23",
language = "English",
volume = "84",
pages = "551--62",
journal = "CELL",
issn = "0092-8674",
publisher = "Cell Press",
number = "4",

}

RIS

TY - JOUR

T1 - Impaired negative selection of T cells in Hodgkin's disease antigen CD30-deficient mice

AU - Amakawa, R

AU - Hakem, A

AU - Kundig, T M

AU - Matsuyama, T

AU - Simard, J J

AU - Timms, E

AU - Wakeham, A

AU - Mittrücker, Hans-Willi

AU - Griesser, H

AU - Takimoto, H

AU - Schmits, R

AU - Shahinian, A

AU - Ohashi, P

AU - Penninger, J M

AU - Mak, T W

AU - Mittrücker, Hans-Willi

PY - 1996/2/23

Y1 - 1996/2/23

N2 - CD30 is found on Reed-Sternberg cells of Hodgkin's disease and on a variety of non-Hodgkin's lymphoma cells and is up-regulated on cells after Epstein-Barr virus, human T cell leukemia virus, and HIV infections. We report here that the thymus in CD30-deficient mice contains elevated numbers of thymocytes. Activation-induced death of thymocytes after CD3 cross-linking is impaired both in vitro and in vivo. Breeding the CD30 mutation separately into alpha beta TCR-or gamma delta TCR-transgenic mice revealed a gross defect in negative but not positive selection. Thus, like TNF-receptors and Fas/Apo-1, the CD30 receptor is involved in cell death signaling. It is also an important coreceptor that participates in thymic deletion.

AB - CD30 is found on Reed-Sternberg cells of Hodgkin's disease and on a variety of non-Hodgkin's lymphoma cells and is up-regulated on cells after Epstein-Barr virus, human T cell leukemia virus, and HIV infections. We report here that the thymus in CD30-deficient mice contains elevated numbers of thymocytes. Activation-induced death of thymocytes after CD3 cross-linking is impaired both in vitro and in vivo. Breeding the CD30 mutation separately into alpha beta TCR-or gamma delta TCR-transgenic mice revealed a gross defect in negative but not positive selection. Thus, like TNF-receptors and Fas/Apo-1, the CD30 receptor is involved in cell death signaling. It is also an important coreceptor that participates in thymic deletion.

KW - Animals

KW - Antigens, CD30

KW - B-Lymphocytes

KW - Base Sequence

KW - Cell Death

KW - Cell Differentiation

KW - Cell Separation

KW - Gene Deletion

KW - Gene Expression

KW - Hodgkin Disease

KW - Lymph Nodes

KW - Male

KW - Mice

KW - Mice, Mutant Strains

KW - Molecular Sequence Data

KW - Receptors, Antigen, T-Cell, alpha-beta

KW - Receptors, Antigen, T-Cell, gamma-delta

KW - Signal Transduction

KW - Superantigens

KW - T-Lymphocytes

KW - Thymus Gland

M3 - SCORING: Journal article

C2 - 8598042

VL - 84

SP - 551

EP - 562

JO - CELL

JF - CELL

SN - 0092-8674

IS - 4

ER -