Impact of the Lysine-urethane Adhesive TissuGlu® on Postoperative Complications and Interventions After Drain-free Mastectomy
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Impact of the Lysine-urethane Adhesive TissuGlu® on Postoperative Complications and Interventions After Drain-free Mastectomy. / Ohlinger, Ralf; Rutkowski, Rico; Kohlmann, Thomas; Paepke, Stefan; Alwafai, Zaher; Flieger, Carolin; Möller, Sylke; Lenz, Franziska; Zygmunt, Marek; Unger, Julia.
In: ANTICANCER RES, Vol. 40, No. 5, 05.2020, p. 2801-2812.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Impact of the Lysine-urethane Adhesive TissuGlu® on Postoperative Complications and Interventions After Drain-free Mastectomy
AU - Ohlinger, Ralf
AU - Rutkowski, Rico
AU - Kohlmann, Thomas
AU - Paepke, Stefan
AU - Alwafai, Zaher
AU - Flieger, Carolin
AU - Möller, Sylke
AU - Lenz, Franziska
AU - Zygmunt, Marek
AU - Unger, Julia
N1 - Copyright© 2020, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
PY - 2020/5
Y1 - 2020/5
N2 - BACKGROUND/AIM: The influence of a polyurethane-based tissue adhesive (TissuGlu®) on common complications following breast surgery was investigated.PATIENTS AND METHODS: Within a Randomized-Controlled-Trial 70 women (n=35 TissuGlu®, n=35 drain) underwent a mastectomy with or without sentinel lymph node excision (SLNE), followed by a 90-day postoperative follow-up.RESULTS: Postoperative interventions: Non-inferiority of the application of TissuGlu® was seen. Pain-Level/ Hospitalization: A statistically significant pain reduction from day four onwards (p<0.001) and a shorter hospitalization period (p<0.001) was observed. In contrast, the TissuGlu® group showed increased mean puncture incidence (p=0.013), and increased puncture volume (p=0.021).CONCLUSION: Application of the polyurethane-based tissue adhesive TissuGlu® after mastectomy, with or without SLNE, showed potential for improvement of the clinical outcome. In contrast, high intervention rates and increased puncture volume, caused by recurring seromas following application of the surgical adhesive TissuGlu®, have a negative impact on the patient-specific convalescence.
AB - BACKGROUND/AIM: The influence of a polyurethane-based tissue adhesive (TissuGlu®) on common complications following breast surgery was investigated.PATIENTS AND METHODS: Within a Randomized-Controlled-Trial 70 women (n=35 TissuGlu®, n=35 drain) underwent a mastectomy with or without sentinel lymph node excision (SLNE), followed by a 90-day postoperative follow-up.RESULTS: Postoperative interventions: Non-inferiority of the application of TissuGlu® was seen. Pain-Level/ Hospitalization: A statistically significant pain reduction from day four onwards (p<0.001) and a shorter hospitalization period (p<0.001) was observed. In contrast, the TissuGlu® group showed increased mean puncture incidence (p=0.013), and increased puncture volume (p=0.021).CONCLUSION: Application of the polyurethane-based tissue adhesive TissuGlu® after mastectomy, with or without SLNE, showed potential for improvement of the clinical outcome. In contrast, high intervention rates and increased puncture volume, caused by recurring seromas following application of the surgical adhesive TissuGlu®, have a negative impact on the patient-specific convalescence.
KW - Adhesives/adverse effects
KW - Female
KW - Humans
KW - Lysine/adverse effects
KW - Mastectomy/adverse effects
KW - Postoperative Period
KW - Prospective Studies
KW - Retrospective Studies
KW - Treatment Outcome
KW - Urethane/adverse effects
U2 - 10.21873/anticanres.14253
DO - 10.21873/anticanres.14253
M3 - SCORING: Journal article
C2 - 32366427
VL - 40
SP - 2801
EP - 2812
JO - ANTICANCER RES
JF - ANTICANCER RES
SN - 0250-7005
IS - 5
ER -
