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Impact of Surgery on Long-Term Results of Hearing in Neurofibromatosis Type-2 Associated Vestibular Schwannomas

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Impact of Surgery on Long-Term Results of Hearing in Neurofibromatosis Type-2 Associated Vestibular Schwannomas. / Gugel, Isabel; Grimm, Florian; Liebsch, Marina; Zipfel, Julian; Teuber, Christian; Kluwe, Lan; Mautner, Victor-Felix; Tatagiba, Marcos; Schuhmann, Martin Ulrich.

In: CANCERS, Vol. 11, No. 9, 16.09.2019.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Gugel, I, Grimm, F, Liebsch, M, Zipfel, J, Teuber, C, Kluwe, L, Mautner, V-F, Tatagiba, M & Schuhmann, MU 2019, 'Impact of Surgery on Long-Term Results of Hearing in Neurofibromatosis Type-2 Associated Vestibular Schwannomas', CANCERS, vol. 11, no. 9. https://doi.org/10.3390/cancers11091376

APA

Gugel, I., Grimm, F., Liebsch, M., Zipfel, J., Teuber, C., Kluwe, L., Mautner, V-F., Tatagiba, M., & Schuhmann, M. U. (2019). Impact of Surgery on Long-Term Results of Hearing in Neurofibromatosis Type-2 Associated Vestibular Schwannomas. CANCERS, 11(9). https://doi.org/10.3390/cancers11091376

Vancouver

Gugel I, Grimm F, Liebsch M, Zipfel J, Teuber C, Kluwe L et al. Impact of Surgery on Long-Term Results of Hearing in Neurofibromatosis Type-2 Associated Vestibular Schwannomas. CANCERS. 2019 Sep 16;11(9). https://doi.org/10.3390/cancers11091376

Bibtex

@article{5f021b5795234db7bd88102acd867469,
title = "Impact of Surgery on Long-Term Results of Hearing in Neurofibromatosis Type-2 Associated Vestibular Schwannomas",
abstract = "Hearing preservation is a major goal in the treatment of neurofibromatosis type 2 (NF2) associated vestibular schwannoma (VS), particularly in children and adolescents. In this study, we retrospectively reviewed hearing and volumetry data sets of 39 operated tumors (ears) in 23 patients under the age of 25 and in a follow-up period of 21 to 167 months. Hearing data over a compatible period on 20 other tumors, which did not receive surgery due to their less aggressive nature, were included for comparison. Surgery was carried out via a retrosigmoid approach with the brainstem auditory evoked potential (BAEP) guide. Immediately after surgery, functional hearing was maintained in 82% of ears. Average hearing scores were better in the non-surgery ears. However, the hearing scores in both groups worsened gradually with a similar dynamic during the 42-month postoperative follow-up period. No accelerated impairment of hearing was evident for the operated cases. Rather, the gap between the two hearing deterioration lines tended to close at the end of the follow-up period. Our result suggested that the BAEP-guided surgery did not cause additional hearing deterioration in the long-term and seemed to slow down hearing deterioration of those tumors that were initially more aggressive.",
author = "Isabel Gugel and Florian Grimm and Marina Liebsch and Julian Zipfel and Christian Teuber and Lan Kluwe and Victor-Felix Mautner and Marcos Tatagiba and Schuhmann, {Martin Ulrich}",
year = "2019",
month = sep,
day = "16",
doi = "10.3390/cancers11091376",
language = "English",
volume = "11",
journal = "CANCERS",
issn = "2072-6694",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "9",

}

RIS

TY - JOUR

T1 - Impact of Surgery on Long-Term Results of Hearing in Neurofibromatosis Type-2 Associated Vestibular Schwannomas

AU - Gugel, Isabel

AU - Grimm, Florian

AU - Liebsch, Marina

AU - Zipfel, Julian

AU - Teuber, Christian

AU - Kluwe, Lan

AU - Mautner, Victor-Felix

AU - Tatagiba, Marcos

AU - Schuhmann, Martin Ulrich

PY - 2019/9/16

Y1 - 2019/9/16

N2 - Hearing preservation is a major goal in the treatment of neurofibromatosis type 2 (NF2) associated vestibular schwannoma (VS), particularly in children and adolescents. In this study, we retrospectively reviewed hearing and volumetry data sets of 39 operated tumors (ears) in 23 patients under the age of 25 and in a follow-up period of 21 to 167 months. Hearing data over a compatible period on 20 other tumors, which did not receive surgery due to their less aggressive nature, were included for comparison. Surgery was carried out via a retrosigmoid approach with the brainstem auditory evoked potential (BAEP) guide. Immediately after surgery, functional hearing was maintained in 82% of ears. Average hearing scores were better in the non-surgery ears. However, the hearing scores in both groups worsened gradually with a similar dynamic during the 42-month postoperative follow-up period. No accelerated impairment of hearing was evident for the operated cases. Rather, the gap between the two hearing deterioration lines tended to close at the end of the follow-up period. Our result suggested that the BAEP-guided surgery did not cause additional hearing deterioration in the long-term and seemed to slow down hearing deterioration of those tumors that were initially more aggressive.

AB - Hearing preservation is a major goal in the treatment of neurofibromatosis type 2 (NF2) associated vestibular schwannoma (VS), particularly in children and adolescents. In this study, we retrospectively reviewed hearing and volumetry data sets of 39 operated tumors (ears) in 23 patients under the age of 25 and in a follow-up period of 21 to 167 months. Hearing data over a compatible period on 20 other tumors, which did not receive surgery due to their less aggressive nature, were included for comparison. Surgery was carried out via a retrosigmoid approach with the brainstem auditory evoked potential (BAEP) guide. Immediately after surgery, functional hearing was maintained in 82% of ears. Average hearing scores were better in the non-surgery ears. However, the hearing scores in both groups worsened gradually with a similar dynamic during the 42-month postoperative follow-up period. No accelerated impairment of hearing was evident for the operated cases. Rather, the gap between the two hearing deterioration lines tended to close at the end of the follow-up period. Our result suggested that the BAEP-guided surgery did not cause additional hearing deterioration in the long-term and seemed to slow down hearing deterioration of those tumors that were initially more aggressive.

U2 - 10.3390/cancers11091376

DO - 10.3390/cancers11091376

M3 - SCORING: Journal article

C2 - 31527541

VL - 11

JO - CANCERS

JF - CANCERS

SN - 2072-6694

IS - 9

ER -