Impact of stereotactic radiosurgery dose on control of cerebral metastases from renal cell carcinoma

Dirk Rades; Stefan Huttenlocher; Niklas Gebauer; Dagmar Hornung; Ngo Thuy Trang; Mai Trong Khoa; Steven E Schild

Impact of stereotactic radiosurgery dose on control of cerebral metastases from renal cell carcinoma

Standard

Impact of stereotactic radiosurgery dose on control of cerebral metastases from renal cell carcinoma. / Rades, Dirk; Huttenlocher, Stefan; Gebauer, Niklas; Hornung, Dagmar; Trang, Ngo Thuy; Khoa, Mai Trong; Schild, Steven E.

In: ANTICANCER RES, Vol. 35, No. 6, 06.2015, p. 3571-4.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Rades, D, Huttenlocher, S, Gebauer, N, Hornung, D, Trang, NT, Khoa, MT & Schild, SE 2015, 'Impact of stereotactic radiosurgery dose on control of cerebral metastases from renal cell carcinoma', ANTICANCER RES, vol. 35, no. 6, pp. 3571-4.

APA

Rades, D., Huttenlocher, S., Gebauer, N., Hornung, D., Trang, N. T., Khoa, M. T., & Schild, S. E. (2015). Impact of stereotactic radiosurgery dose on control of cerebral metastases from renal cell carcinoma. ANTICANCER RES, 35(6), 3571-4.

Vancouver

Rades D, Huttenlocher S, Gebauer N, Hornung D, Trang NT, Khoa MT et al. Impact of stereotactic radiosurgery dose on control of cerebral metastases from renal cell carcinoma. ANTICANCER RES. 2015 Jun;35(6):3571-4.

Bibtex

@article{cfecbd197a854f9384ec880baf67160f,

title = "Impact of stereotactic radiosurgery dose on control of cerebral metastases from renal cell carcinoma",

abstract = "AIM: Renal cell carcinoma (RCC) is a relatively radioresistant tumor and may require for higher radiation doses than other tumor types.PATIENTS AND METHODS: Nineteen patients treated with 20 Gy of stereotactic radiosurgery (SRS) alone for one to three cerebral metastases were compared to nine patients treated with 16-18 Gy.RESULTS: SRS with 20 Gy led to significantly better local control than did 16-18 Gy (81% vs. 50% at 12 months; p<0.001). Results were also significant on multivariate analysis (risk ratio: 6.30; p=0.033). SRS dose did not associate with freedom from new cerebral metastases (75% vs. 62% at 12 months; p=0.42) or survival (16% vs. 56% at 12 months; p=0.46). On multivariate analyses, better survival was associated with higher Karnofsky performance score (p<0.001) and absence of extracranial metastatic disease (p=0.006).CONCLUSION: In patients treated with SRS alone, local control of cerebral metastases from RCC was better after 20 Gy than after 16-18 Gy.",

keywords = "Aged, Brain Neoplasms, Carcinoma, Renal Cell, Female, Humans, Kaplan-Meier Estimate, Karnofsky Performance Status, Male, Middle Aged, Neoplasms, Radiation-Induced, Proportional Hazards Models, Radiosurgery, Radiotherapy Dosage",

author = "Dirk Rades and Stefan Huttenlocher and Niklas Gebauer and Dagmar Hornung and Trang, {Ngo Thuy} and Khoa, {Mai Trong} and Schild, {Steven E}",

year = "2015",

month = jun,

language = "English",

volume = "35",

pages = "3571--4",

journal = "ANTICANCER RES",

issn = "0250-7005",

publisher = "International Institute of Anticancer Research",

number = "6",

}

RIS

TY - JOUR

T1 - Impact of stereotactic radiosurgery dose on control of cerebral metastases from renal cell carcinoma

AU - Rades, Dirk

AU - Huttenlocher, Stefan

AU - Gebauer, Niklas

AU - Hornung, Dagmar

AU - Trang, Ngo Thuy

AU - Khoa, Mai Trong

AU - Schild, Steven E

PY - 2015/6

Y1 - 2015/6

N2 - AIM: Renal cell carcinoma (RCC) is a relatively radioresistant tumor and may require for higher radiation doses than other tumor types.PATIENTS AND METHODS: Nineteen patients treated with 20 Gy of stereotactic radiosurgery (SRS) alone for one to three cerebral metastases were compared to nine patients treated with 16-18 Gy.RESULTS: SRS with 20 Gy led to significantly better local control than did 16-18 Gy (81% vs. 50% at 12 months; p<0.001). Results were also significant on multivariate analysis (risk ratio: 6.30; p=0.033). SRS dose did not associate with freedom from new cerebral metastases (75% vs. 62% at 12 months; p=0.42) or survival (16% vs. 56% at 12 months; p=0.46). On multivariate analyses, better survival was associated with higher Karnofsky performance score (p<0.001) and absence of extracranial metastatic disease (p=0.006).CONCLUSION: In patients treated with SRS alone, local control of cerebral metastases from RCC was better after 20 Gy than after 16-18 Gy.

AB - AIM: Renal cell carcinoma (RCC) is a relatively radioresistant tumor and may require for higher radiation doses than other tumor types.PATIENTS AND METHODS: Nineteen patients treated with 20 Gy of stereotactic radiosurgery (SRS) alone for one to three cerebral metastases were compared to nine patients treated with 16-18 Gy.RESULTS: SRS with 20 Gy led to significantly better local control than did 16-18 Gy (81% vs. 50% at 12 months; p<0.001). Results were also significant on multivariate analysis (risk ratio: 6.30; p=0.033). SRS dose did not associate with freedom from new cerebral metastases (75% vs. 62% at 12 months; p=0.42) or survival (16% vs. 56% at 12 months; p=0.46). On multivariate analyses, better survival was associated with higher Karnofsky performance score (p<0.001) and absence of extracranial metastatic disease (p=0.006).CONCLUSION: In patients treated with SRS alone, local control of cerebral metastases from RCC was better after 20 Gy than after 16-18 Gy.

KW - Aged

KW - Brain Neoplasms

KW - Carcinoma, Renal Cell

KW - Female

KW - Humans

KW - Kaplan-Meier Estimate

KW - Karnofsky Performance Status

KW - Male

KW - Middle Aged

KW - Neoplasms, Radiation-Induced

KW - Proportional Hazards Models

KW - Radiosurgery

KW - Radiotherapy Dosage

M3 - SCORING: Journal article

C2 - 26026128

VL - 35

SP - 3571

EP - 3574

JO - ANTICANCER RES

JF - ANTICANCER RES

SN - 0250-7005

IS - 6

ER -