Impact of Sex and Cardiovascular Risk Factors on Myocardial T1, Extracellular Volume Fraction, and T2 at 3 Tesla: Results From the Population-Based, Hamburg City Health Study
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Impact of Sex and Cardiovascular Risk Factors on Myocardial T1, Extracellular Volume Fraction, and T2 at 3 Tesla: Results From the Population-Based, Hamburg City Health Study. / Cavus, Ersin; Schneider, Jan N; Bei der Kellen, Ramona; di Carluccio, Eleonora; Ziegler, Andreas; Tahir, Enver; Bohnen, Sebastian; Avanesov, Maxim; Radunski, Ulf K; Chevalier, Celeste; Jahnke, Charlotte; Ojeda, Francisco; Kirchhof, Paulus; Blankenberg, Stefan; Adam, Gerhard; Lund, Gunnar K; Muellerleile, Kai.
In: CIRC-CARDIOVASC IMAG, Vol. 15, No. 9, e014158, 09.2022.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Impact of Sex and Cardiovascular Risk Factors on Myocardial T1, Extracellular Volume Fraction, and T2 at 3 Tesla: Results From the Population-Based, Hamburg City Health Study
AU - Cavus, Ersin
AU - Schneider, Jan N
AU - Bei der Kellen, Ramona
AU - di Carluccio, Eleonora
AU - Ziegler, Andreas
AU - Tahir, Enver
AU - Bohnen, Sebastian
AU - Avanesov, Maxim
AU - Radunski, Ulf K
AU - Chevalier, Celeste
AU - Jahnke, Charlotte
AU - Ojeda, Francisco
AU - Kirchhof, Paulus
AU - Blankenberg, Stefan
AU - Adam, Gerhard
AU - Lund, Gunnar K
AU - Muellerleile, Kai
PY - 2022/9
Y1 - 2022/9
N2 - BACKGROUND: Reliable reference intervals are crucial for clinical application of myocardial T1 and T2 mapping cardiovascular magnetic resonance imaging. This study evaluated the impact of sex and cardiovascular risk factors on myocardial T1, extracellular volume fraction (ECV), and T2 at 3T in the population-based HCHS (Hamburg City Health Study).METHODS: The final study sample consisted of 1576 consecutive HCHS participants between 46 and 78 years without prevalent heart disease, including 1020 (67.3%) participants with hypertension and 110 (7.5%) with diabetes. T1 and T2 mapping were performed on a 3T scanner using 5b(3b)3b modified Look-Locker inversion recovery and T2 prepared, fast-low-angle shot sequence, respectively. Stepwise regression analyses were performed to identify variables with an independent impact on T1, ECV, and T2. Reference intervals were defined as the interval between the 2.5% and 97.5% quantiles.RESULTS: Sex was the major independent influencing factor of myocardial native T1, ECV, and T2. Female patients had significantly higher upper limits of reference intervals for native T1 (1112-1261 versus 1079-1241 ms), ECV (23%-33% versus 22%-32%), and T2 (36-46 versus 35-45 ms) compared with male patients (all P<0.001). Cardiovascular risk factors, such as diabetes and hypertension, did not systematically affect native T1. There was an independent association of T2 by hypertension and, to a lesser degree, by left ventricular mass, heart rate (all P<0.001), and body mass index (P=0.001).CONCLUSIONS: Sex needs to be considered as the major, independent influencing factor for clinical application of myocardial T1, ECV, and T2 measurements. Consequently, sex-specific reference intervals should be used in clinical routine. Our findings suggest that there is no need for specific reference intervals for myocardial T1 and ECV measurements in individuals with cardiovascular risk factors. However, hypertension should be considered as an additional factor for clinical application of T2 measurements.REGISTRATION: URL: https://www.CLINICALTRIALS: gov; Unique identifier: NCT03934957.
AB - BACKGROUND: Reliable reference intervals are crucial for clinical application of myocardial T1 and T2 mapping cardiovascular magnetic resonance imaging. This study evaluated the impact of sex and cardiovascular risk factors on myocardial T1, extracellular volume fraction (ECV), and T2 at 3T in the population-based HCHS (Hamburg City Health Study).METHODS: The final study sample consisted of 1576 consecutive HCHS participants between 46 and 78 years without prevalent heart disease, including 1020 (67.3%) participants with hypertension and 110 (7.5%) with diabetes. T1 and T2 mapping were performed on a 3T scanner using 5b(3b)3b modified Look-Locker inversion recovery and T2 prepared, fast-low-angle shot sequence, respectively. Stepwise regression analyses were performed to identify variables with an independent impact on T1, ECV, and T2. Reference intervals were defined as the interval between the 2.5% and 97.5% quantiles.RESULTS: Sex was the major independent influencing factor of myocardial native T1, ECV, and T2. Female patients had significantly higher upper limits of reference intervals for native T1 (1112-1261 versus 1079-1241 ms), ECV (23%-33% versus 22%-32%), and T2 (36-46 versus 35-45 ms) compared with male patients (all P<0.001). Cardiovascular risk factors, such as diabetes and hypertension, did not systematically affect native T1. There was an independent association of T2 by hypertension and, to a lesser degree, by left ventricular mass, heart rate (all P<0.001), and body mass index (P=0.001).CONCLUSIONS: Sex needs to be considered as the major, independent influencing factor for clinical application of myocardial T1, ECV, and T2 measurements. Consequently, sex-specific reference intervals should be used in clinical routine. Our findings suggest that there is no need for specific reference intervals for myocardial T1 and ECV measurements in individuals with cardiovascular risk factors. However, hypertension should be considered as an additional factor for clinical application of T2 measurements.REGISTRATION: URL: https://www.CLINICALTRIALS: gov; Unique identifier: NCT03934957.
KW - Cardiovascular Diseases/diagnostic imaging
KW - Female
KW - Heart Disease Risk Factors
KW - Humans
KW - Hypertension/diagnosis
KW - Magnetic Resonance Imaging, Cine/methods
KW - Male
KW - Risk Factors
U2 - 10.1161/CIRCIMAGING.122.014158
DO - 10.1161/CIRCIMAGING.122.014158
M3 - SCORING: Journal article
C2 - 36126126
VL - 15
JO - CIRC-CARDIOVASC IMAG
JF - CIRC-CARDIOVASC IMAG
SN - 1941-9651
IS - 9
M1 - e014158
ER -