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Impact of refugee influx on the epidemiology of late-presenting HIV-infected pregnant women and mother-to-child transmission: comparing a southern and northern medical centre in Germany

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Impact of refugee influx on the epidemiology of late-presenting HIV-infected pregnant women and mother-to-child transmission: comparing a southern and northern medical centre in Germany. / Singer, Katharina; Schulze-Sturm, Ulf; Alba-Alejandre, Irene; Hollwitz, Bettina; Nguyen, Thi Thanh Truc; Sollinger, Franz; Eberle, Josef; Hübner, Johannes; Kobbe, Robin; Genzel-Boroviczény, Orsolya; von Both, Ulrich.

In: INFECTION, Vol. 47, No. 5, 10.2019, p. 847-852.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Singer, K, Schulze-Sturm, U, Alba-Alejandre, I, Hollwitz, B, Nguyen, TTT, Sollinger, F, Eberle, J, Hübner, J, Kobbe, R, Genzel-Boroviczény, O & von Both, U 2019, 'Impact of refugee influx on the epidemiology of late-presenting HIV-infected pregnant women and mother-to-child transmission: comparing a southern and northern medical centre in Germany', INFECTION, vol. 47, no. 5, pp. 847-852. https://doi.org/10.1007/s15010-019-01332-3

APA

Singer, K., Schulze-Sturm, U., Alba-Alejandre, I., Hollwitz, B., Nguyen, T. T. T., Sollinger, F., Eberle, J., Hübner, J., Kobbe, R., Genzel-Boroviczény, O., & von Both, U. (2019). Impact of refugee influx on the epidemiology of late-presenting HIV-infected pregnant women and mother-to-child transmission: comparing a southern and northern medical centre in Germany. INFECTION, 47(5), 847-852. https://doi.org/10.1007/s15010-019-01332-3

Vancouver

Singer K, Schulze-Sturm U, Alba-Alejandre I, Hollwitz B, Nguyen TTT, Sollinger F et al. Impact of refugee influx on the epidemiology of late-presenting HIV-infected pregnant women and mother-to-child transmission: comparing a southern and northern medical centre in Germany. INFECTION. 2019 Oct;47(5):847-852. https://doi.org/10.1007/s15010-019-01332-3

Bibtex

@article{9329d7cb5d0b4df18d7045386097a7ca,
title = "Impact of refugee influx on the epidemiology of late-presenting HIV-infected pregnant women and mother-to-child transmission: comparing a southern and northern medical centre in Germany",
abstract = "PURPOSE: Due to early antenatal screening and treatment, HIV mother-to-child transmission (MTCT) rarely occurs in Germany. The study aimed to investigate the impact on prevalence of HIV infection in the antenatal population and the incidence of late-presenting HIV-infected mothers attributable to increased numbers of refugees.METHODS: Retrospective analysis and comparison were performed for all deliveries in HIV-infected pregnant women presenting to medical care in Munich (southern Germany) and Hamburg (northern Germany) covering two time periods, A (2010-2012) and B (2013-2015).RESULTS: In Munich, deliveries in HIV-infected pregnant women increased 1.6-fold from period A (n = 50) to B (n = 79) with late-presenting cases rising significantly from 2% (1/50) in period A to 13% (10/79) in B. In contrast, late-presenting cases in Hamburg decreased from 14% (14/100) in period A to 7% (7/107) in B, while the total number of HIV-infected women giving birth remained stable. From 2010 to 2015, one late-presenting pregnant woman transmitted HIV in Munich by presumed in utero mode of infection (case reviewed here), while no MTCT occurred in Hamburg.CONCLUSIONS: HIV infections diagnosed late in pregnancy and leading to delayed ART initiation are rising in Munich compared to Hamburg. Antenatal care of HIV-infected pregnant women in Munich appears to have been more affected by the recent refugee influx than Hamburg. Our study highlights the importance of screening all pregnant women for HIV early in pregnancy and providing timely health care access for pregnant refugees and asylum seekers to effectively prevent MTCT in Germany.",
author = "Katharina Singer and Ulf Schulze-Sturm and Irene Alba-Alejandre and Bettina Hollwitz and Nguyen, {Thi Thanh Truc} and Franz Sollinger and Josef Eberle and Johannes H{\"u}bner and Robin Kobbe and Orsolya Genzel-Borovicz{\'e}ny and {von Both}, Ulrich",
year = "2019",
month = oct,
doi = "10.1007/s15010-019-01332-3",
language = "English",
volume = "47",
pages = "847--852",
journal = "INFECTION",
issn = "0300-8126",
publisher = "Urban und Vogel",
number = "5",

}

RIS

TY - JOUR

T1 - Impact of refugee influx on the epidemiology of late-presenting HIV-infected pregnant women and mother-to-child transmission: comparing a southern and northern medical centre in Germany

AU - Singer, Katharina

AU - Schulze-Sturm, Ulf

AU - Alba-Alejandre, Irene

AU - Hollwitz, Bettina

AU - Nguyen, Thi Thanh Truc

AU - Sollinger, Franz

AU - Eberle, Josef

AU - Hübner, Johannes

AU - Kobbe, Robin

AU - Genzel-Boroviczény, Orsolya

AU - von Both, Ulrich

PY - 2019/10

Y1 - 2019/10

N2 - PURPOSE: Due to early antenatal screening and treatment, HIV mother-to-child transmission (MTCT) rarely occurs in Germany. The study aimed to investigate the impact on prevalence of HIV infection in the antenatal population and the incidence of late-presenting HIV-infected mothers attributable to increased numbers of refugees.METHODS: Retrospective analysis and comparison were performed for all deliveries in HIV-infected pregnant women presenting to medical care in Munich (southern Germany) and Hamburg (northern Germany) covering two time periods, A (2010-2012) and B (2013-2015).RESULTS: In Munich, deliveries in HIV-infected pregnant women increased 1.6-fold from period A (n = 50) to B (n = 79) with late-presenting cases rising significantly from 2% (1/50) in period A to 13% (10/79) in B. In contrast, late-presenting cases in Hamburg decreased from 14% (14/100) in period A to 7% (7/107) in B, while the total number of HIV-infected women giving birth remained stable. From 2010 to 2015, one late-presenting pregnant woman transmitted HIV in Munich by presumed in utero mode of infection (case reviewed here), while no MTCT occurred in Hamburg.CONCLUSIONS: HIV infections diagnosed late in pregnancy and leading to delayed ART initiation are rising in Munich compared to Hamburg. Antenatal care of HIV-infected pregnant women in Munich appears to have been more affected by the recent refugee influx than Hamburg. Our study highlights the importance of screening all pregnant women for HIV early in pregnancy and providing timely health care access for pregnant refugees and asylum seekers to effectively prevent MTCT in Germany.

AB - PURPOSE: Due to early antenatal screening and treatment, HIV mother-to-child transmission (MTCT) rarely occurs in Germany. The study aimed to investigate the impact on prevalence of HIV infection in the antenatal population and the incidence of late-presenting HIV-infected mothers attributable to increased numbers of refugees.METHODS: Retrospective analysis and comparison were performed for all deliveries in HIV-infected pregnant women presenting to medical care in Munich (southern Germany) and Hamburg (northern Germany) covering two time periods, A (2010-2012) and B (2013-2015).RESULTS: In Munich, deliveries in HIV-infected pregnant women increased 1.6-fold from period A (n = 50) to B (n = 79) with late-presenting cases rising significantly from 2% (1/50) in period A to 13% (10/79) in B. In contrast, late-presenting cases in Hamburg decreased from 14% (14/100) in period A to 7% (7/107) in B, while the total number of HIV-infected women giving birth remained stable. From 2010 to 2015, one late-presenting pregnant woman transmitted HIV in Munich by presumed in utero mode of infection (case reviewed here), while no MTCT occurred in Hamburg.CONCLUSIONS: HIV infections diagnosed late in pregnancy and leading to delayed ART initiation are rising in Munich compared to Hamburg. Antenatal care of HIV-infected pregnant women in Munich appears to have been more affected by the recent refugee influx than Hamburg. Our study highlights the importance of screening all pregnant women for HIV early in pregnancy and providing timely health care access for pregnant refugees and asylum seekers to effectively prevent MTCT in Germany.

U2 - 10.1007/s15010-019-01332-3

DO - 10.1007/s15010-019-01332-3

M3 - SCORING: Journal article

C2 - 31190299

VL - 47

SP - 847

EP - 852

JO - INFECTION

JF - INFECTION

SN - 0300-8126

IS - 5

ER -