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Impact of reassessment of colonic hyperplastic polyps by expert GI pathologists

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Impact of reassessment of colonic hyperplastic polyps by expert GI pathologists. / Schachschal, Guido; Sehner, Susanne; Choschzick, Matthias; Aust, Daniela; Brandl, Lydia; Vieth, Michael; Wegscheider, Karl; Baretton, Gustavo B; Kirchner, Thomas; Sauter, Guido; Rösch, Thomas.

In: INT J COLORECTAL DIS, Vol. 31, No. 3, 03.2016, p. 675-683.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Schachschal, G, Sehner, S, Choschzick, M, Aust, D, Brandl, L, Vieth, M, Wegscheider, K, Baretton, GB, Kirchner, T, Sauter, G & Rösch, T 2016, 'Impact of reassessment of colonic hyperplastic polyps by expert GI pathologists', INT J COLORECTAL DIS, vol. 31, no. 3, pp. 675-683. https://doi.org/10.1007/s00384-016-2523-8

APA

Schachschal, G., Sehner, S., Choschzick, M., Aust, D., Brandl, L., Vieth, M., Wegscheider, K., Baretton, G. B., Kirchner, T., Sauter, G., & Rösch, T. (2016). Impact of reassessment of colonic hyperplastic polyps by expert GI pathologists. INT J COLORECTAL DIS, 31(3), 675-683. https://doi.org/10.1007/s00384-016-2523-8

Vancouver

Schachschal G, Sehner S, Choschzick M, Aust D, Brandl L, Vieth M et al. Impact of reassessment of colonic hyperplastic polyps by expert GI pathologists. INT J COLORECTAL DIS. 2016 Mar;31(3):675-683. https://doi.org/10.1007/s00384-016-2523-8

Bibtex

@article{b31d300d5d3e4189b7ad65b27bbe70ce,
title = "Impact of reassessment of colonic hyperplastic polyps by expert GI pathologists",
abstract = "BACKGROUND: Recommended follow-up intervals after endoscopic removal of hyperplastic polyps (HP) and sessile serrated adenomas (SSA) differ because of assumed differences in biological behaviour. However, histopathologic differentiation is difficult, with higher SSA rates reported from specialist GI histopathologists.OBJECTIVE: The objective of this study was to clarify the relevance of histologic reassessment of HP.DESIGN AND SETTING: From a prospective screening colonoscopy study relevant serrated lesions (excluding distal small HP ≤5 mm) diagnosed by private practice pathologists were reassessed by four specialized GI pathologistsPATIENTS: One thousand sixty-nine screening colonoscopies were performed in patients.MAIN OUTCOME MEASUREMENTS: In terms of main outcome measurements, there is a likelihood of changes of the HP diagnosis on reassessment, as well as interrater variability.RESULTS: SSA were initially diagnosed in 7 cases (0.7 %) and relevant HP in 83 (7.8 %; 101 lesions). Of the latter, the chance of a change in diagnosis from HP to SSA by any of the four specialist histopathologists was higher for larger (>5 mm) and right-sided lesions (19.1 vs 1.3 %, OR 18.4, p = 0.04) including a higher likelihood to change recommended follow-up intervals (32.1 vs 3.3 %, p < 0.01). However, follow-up intervals were determined by concomitant adenomas in 41 %. Interrater variability was also higher for these lesions (p = 0.04), with an overall kappa value of 0.48. However, this issue related to only 1.2 % of the 1069 study cases.LIMITATION: The limitations this study are the limited case number as well as limited retrospective assessment.CONCLUSIONS: Right-sided HP >5 mm had a higher chance of change in diagnosis to SSA; therefore, they should probably be treated like adenomas and be removed. However, reliable data for recommendations on follow-up intervals of HP or SSA will require follow-up studies.",
author = "Guido Schachschal and Susanne Sehner and Matthias Choschzick and Daniela Aust and Lydia Brandl and Michael Vieth and Karl Wegscheider and Baretton, {Gustavo B} and Thomas Kirchner and Guido Sauter and Thomas R{\"o}sch",
year = "2016",
month = mar,
doi = "10.1007/s00384-016-2523-8",
language = "English",
volume = "31",
pages = "675--683",
journal = "INT J COLORECTAL DIS",
issn = "0179-1958",
publisher = "Springer",
number = "3",

}

RIS

TY - JOUR

T1 - Impact of reassessment of colonic hyperplastic polyps by expert GI pathologists

AU - Schachschal, Guido

AU - Sehner, Susanne

AU - Choschzick, Matthias

AU - Aust, Daniela

AU - Brandl, Lydia

AU - Vieth, Michael

AU - Wegscheider, Karl

AU - Baretton, Gustavo B

AU - Kirchner, Thomas

AU - Sauter, Guido

AU - Rösch, Thomas

PY - 2016/3

Y1 - 2016/3

N2 - BACKGROUND: Recommended follow-up intervals after endoscopic removal of hyperplastic polyps (HP) and sessile serrated adenomas (SSA) differ because of assumed differences in biological behaviour. However, histopathologic differentiation is difficult, with higher SSA rates reported from specialist GI histopathologists.OBJECTIVE: The objective of this study was to clarify the relevance of histologic reassessment of HP.DESIGN AND SETTING: From a prospective screening colonoscopy study relevant serrated lesions (excluding distal small HP ≤5 mm) diagnosed by private practice pathologists were reassessed by four specialized GI pathologistsPATIENTS: One thousand sixty-nine screening colonoscopies were performed in patients.MAIN OUTCOME MEASUREMENTS: In terms of main outcome measurements, there is a likelihood of changes of the HP diagnosis on reassessment, as well as interrater variability.RESULTS: SSA were initially diagnosed in 7 cases (0.7 %) and relevant HP in 83 (7.8 %; 101 lesions). Of the latter, the chance of a change in diagnosis from HP to SSA by any of the four specialist histopathologists was higher for larger (>5 mm) and right-sided lesions (19.1 vs 1.3 %, OR 18.4, p = 0.04) including a higher likelihood to change recommended follow-up intervals (32.1 vs 3.3 %, p < 0.01). However, follow-up intervals were determined by concomitant adenomas in 41 %. Interrater variability was also higher for these lesions (p = 0.04), with an overall kappa value of 0.48. However, this issue related to only 1.2 % of the 1069 study cases.LIMITATION: The limitations this study are the limited case number as well as limited retrospective assessment.CONCLUSIONS: Right-sided HP >5 mm had a higher chance of change in diagnosis to SSA; therefore, they should probably be treated like adenomas and be removed. However, reliable data for recommendations on follow-up intervals of HP or SSA will require follow-up studies.

AB - BACKGROUND: Recommended follow-up intervals after endoscopic removal of hyperplastic polyps (HP) and sessile serrated adenomas (SSA) differ because of assumed differences in biological behaviour. However, histopathologic differentiation is difficult, with higher SSA rates reported from specialist GI histopathologists.OBJECTIVE: The objective of this study was to clarify the relevance of histologic reassessment of HP.DESIGN AND SETTING: From a prospective screening colonoscopy study relevant serrated lesions (excluding distal small HP ≤5 mm) diagnosed by private practice pathologists were reassessed by four specialized GI pathologistsPATIENTS: One thousand sixty-nine screening colonoscopies were performed in patients.MAIN OUTCOME MEASUREMENTS: In terms of main outcome measurements, there is a likelihood of changes of the HP diagnosis on reassessment, as well as interrater variability.RESULTS: SSA were initially diagnosed in 7 cases (0.7 %) and relevant HP in 83 (7.8 %; 101 lesions). Of the latter, the chance of a change in diagnosis from HP to SSA by any of the four specialist histopathologists was higher for larger (>5 mm) and right-sided lesions (19.1 vs 1.3 %, OR 18.4, p = 0.04) including a higher likelihood to change recommended follow-up intervals (32.1 vs 3.3 %, p < 0.01). However, follow-up intervals were determined by concomitant adenomas in 41 %. Interrater variability was also higher for these lesions (p = 0.04), with an overall kappa value of 0.48. However, this issue related to only 1.2 % of the 1069 study cases.LIMITATION: The limitations this study are the limited case number as well as limited retrospective assessment.CONCLUSIONS: Right-sided HP >5 mm had a higher chance of change in diagnosis to SSA; therefore, they should probably be treated like adenomas and be removed. However, reliable data for recommendations on follow-up intervals of HP or SSA will require follow-up studies.

U2 - 10.1007/s00384-016-2523-8

DO - 10.1007/s00384-016-2523-8

M3 - SCORING: Journal article

C2 - 26847619

VL - 31

SP - 675

EP - 683

JO - INT J COLORECTAL DIS

JF - INT J COLORECTAL DIS

SN - 0179-1958

IS - 3

ER -