Impact of protein content on proton diffusibility in intracranial cysts.
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Impact of protein content on proton diffusibility in intracranial cysts. / Goebell, E; Fiehler, J; Martens, T; Hagel, C; Forkert, N D; Russjan, A; Rosenkranz, M; Buhk, J-H; Groth, M; Sedlacik, J.
In: ROFO-FORTSCHR RONTG, Vol. 185, No. 1, 1, 2013, p. 60-65.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Impact of protein content on proton diffusibility in intracranial cysts.
AU - Goebell, E
AU - Fiehler, J
AU - Martens, T
AU - Hagel, C
AU - Forkert, N D
AU - Russjan, A
AU - Rosenkranz, M
AU - Buhk, J-H
AU - Groth, M
AU - Sedlacik, J
N1 - © Georg Thieme Verlag KG Stuttgart · New York.
PY - 2013
Y1 - 2013
N2 - PURPOSE: The physical background of diffusion phenomena in intracranial cysts is unclear in some cases. To evaluate a potential dependency of proton diffusion on the concentration of proteins in cystic lesions we investigated the correlation of diffusion weighted imaging (DWI) and magnetization transfer ratio imaging (MTR) in intracranial cystic pathologies in vivo and in vitro with protein solutions.MATERIALS AND METHODS: 21 patients (14 male/7 female) with intracranial cystic lesions underwent preoperative MRI (1.5T) including MTR and DWI sequences. For comparison a series of samples with declining concentration of albumin was investigated in vitro with a 7T animal scanner. Results: In the patients examination mean ADC values were 1.93×10-3mm2/sec and mean MTR values were 0.2. Mean ADC value of the albumin solutions was 0.22× 0-3mm2/sec and mean MTR was 0.12. ADC and MTR values showed a strong negative correlation in the patients (Spearman's rank correlation rs=-0.80, p<0.01) and a very strong negative correlation in the in vitro examinations (rs=-1.0, p<0.01).CONCLUSION: The strong negative correlation of ADC and MTR values suggest a strong influence of proteins on proton diffusion in intracranial cysts. The phenomena can be explained by macromolecules that bind nearby protons in their vicinity.
AB - PURPOSE: The physical background of diffusion phenomena in intracranial cysts is unclear in some cases. To evaluate a potential dependency of proton diffusion on the concentration of proteins in cystic lesions we investigated the correlation of diffusion weighted imaging (DWI) and magnetization transfer ratio imaging (MTR) in intracranial cystic pathologies in vivo and in vitro with protein solutions.MATERIALS AND METHODS: 21 patients (14 male/7 female) with intracranial cystic lesions underwent preoperative MRI (1.5T) including MTR and DWI sequences. For comparison a series of samples with declining concentration of albumin was investigated in vitro with a 7T animal scanner. Results: In the patients examination mean ADC values were 1.93×10-3mm2/sec and mean MTR values were 0.2. Mean ADC value of the albumin solutions was 0.22× 0-3mm2/sec and mean MTR was 0.12. ADC and MTR values showed a strong negative correlation in the patients (Spearman's rank correlation rs=-0.80, p<0.01) and a very strong negative correlation in the in vitro examinations (rs=-1.0, p<0.01).CONCLUSION: The strong negative correlation of ADC and MTR values suggest a strong influence of proteins on proton diffusion in intracranial cysts. The phenomena can be explained by macromolecules that bind nearby protons in their vicinity.
KW - Adult
KW - Humans
KW - Male
KW - Aged
KW - Female
KW - Middle Aged
KW - Young Adult
KW - Reproducibility of Results
KW - Sensitivity and Specificity
KW - Artifacts
KW - Protons
KW - Diffusion
KW - Arachnoid Cysts
KW - Brain Diseases/metabolism/pathology
KW - Cysts/chemistry/pathology
KW - Nerve Tissue Proteins/chemistry
KW - Adult
KW - Humans
KW - Male
KW - Aged
KW - Female
KW - Middle Aged
KW - Young Adult
KW - Reproducibility of Results
KW - Sensitivity and Specificity
KW - Artifacts
KW - Protons
KW - Diffusion
KW - Arachnoid Cysts
KW - Brain Diseases/metabolism/pathology
KW - Cysts/chemistry/pathology
KW - Nerve Tissue Proteins/chemistry
U2 - 10.1055/s-0032-1325406
DO - 10.1055/s-0032-1325406
M3 - SCORING: Journal article
C2 - 23059700
VL - 185
SP - 60
EP - 65
JO - ROFO-FORTSCHR RONTG
JF - ROFO-FORTSCHR RONTG
SN - 1438-9029
IS - 1
M1 - 1
ER -
