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Impact of Propofol Bolus Administration on the Nociceptive Flexion Reflex Threshold and Bispectral Index in Children-A Case Series

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Impact of Propofol Bolus Administration on the Nociceptive Flexion Reflex Threshold and Bispectral Index in Children-A Case Series. / Mauritz, Maximilian David; Uhlenberg, Felix; Vettorazzi, Eik; Ebenebe, Chinedu Ulrich; Singer, Dominique; Deindl, Philipp.

In: CHILDREN-BASEL, Vol. 8, No. 8, 27.07.2021, p. 639.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Mauritz, MD, Uhlenberg, F, Vettorazzi, E, Ebenebe, CU, Singer, D & Deindl, P 2021, 'Impact of Propofol Bolus Administration on the Nociceptive Flexion Reflex Threshold and Bispectral Index in Children-A Case Series', CHILDREN-BASEL, vol. 8, no. 8, pp. 639. https://doi.org/10.3390/children8080639

APA

Mauritz, M. D., Uhlenberg, F., Vettorazzi, E., Ebenebe, C. U., Singer, D., & Deindl, P. (2021). Impact of Propofol Bolus Administration on the Nociceptive Flexion Reflex Threshold and Bispectral Index in Children-A Case Series. CHILDREN-BASEL, 8(8), 639. https://doi.org/10.3390/children8080639

Vancouver

Mauritz MD, Uhlenberg F, Vettorazzi E, Ebenebe CU, Singer D, Deindl P. Impact of Propofol Bolus Administration on the Nociceptive Flexion Reflex Threshold and Bispectral Index in Children-A Case Series. CHILDREN-BASEL. 2021 Jul 27;8(8):639. https://doi.org/10.3390/children8080639

Bibtex

@article{e5b08ae3e9cc44bfb32951c0c6340532,
title = "Impact of Propofol Bolus Administration on the Nociceptive Flexion Reflex Threshold and Bispectral Index in Children-A Case Series",
abstract = "We analyzed the impact of propofol administration during continuous sedation and analgesia on the nociceptive flexion reflex threshold (NFRT) and Bispectral Index (BIS) in ventilated children. We examined patients who received propofol before planned endotracheal suctioning. Patients were clinically assessed using the modified Face, Legs, Activity, Cry, Consolability (mFLACC) scale and COMFORT-B (Comfort Behavior) scale. We continuously recorded the NFRT and BIS. We recorded 23 propofol administrations in eight patients with an average age of 8.6 ± 3.5 years. The median (minimum-maximum) scores for the mFLACC scale and COMFORT-B scale were 0 (0-5) and 6 (6-17), respectively, before the bolus. The administration of a weight-adjusted propofol bolus of 1.03 ± 0.31 mg/kg resulted in an increase in NFRT and burst-suppression ratio; BIS and electromyogram values decreased. Changes from baseline (95% CI) after propofol bolus administration were BIS -23.9 (-30.8 to -17.1), EMG -10.5 dB (-13.3 to -7.7), SR 14.8 % (5.6 to 24.0) and NFRT 13.6 mA (5.5 to 21.7). Further studies are needed to determine whether sedated children may benefit from objective pain and sedation monitoring with BIS and NFRT.",
author = "Mauritz, {Maximilian David} and Felix Uhlenberg and Eik Vettorazzi and Ebenebe, {Chinedu Ulrich} and Dominique Singer and Philipp Deindl",
year = "2021",
month = jul,
day = "27",
doi = "10.3390/children8080639",
language = "English",
volume = "8",
pages = "639",
journal = "CHILDREN-BASEL",
issn = "2227-9067",
publisher = "MDPI AG",
number = "8",

}

RIS

TY - JOUR

T1 - Impact of Propofol Bolus Administration on the Nociceptive Flexion Reflex Threshold and Bispectral Index in Children-A Case Series

AU - Mauritz, Maximilian David

AU - Uhlenberg, Felix

AU - Vettorazzi, Eik

AU - Ebenebe, Chinedu Ulrich

AU - Singer, Dominique

AU - Deindl, Philipp

PY - 2021/7/27

Y1 - 2021/7/27

N2 - We analyzed the impact of propofol administration during continuous sedation and analgesia on the nociceptive flexion reflex threshold (NFRT) and Bispectral Index (BIS) in ventilated children. We examined patients who received propofol before planned endotracheal suctioning. Patients were clinically assessed using the modified Face, Legs, Activity, Cry, Consolability (mFLACC) scale and COMFORT-B (Comfort Behavior) scale. We continuously recorded the NFRT and BIS. We recorded 23 propofol administrations in eight patients with an average age of 8.6 ± 3.5 years. The median (minimum-maximum) scores for the mFLACC scale and COMFORT-B scale were 0 (0-5) and 6 (6-17), respectively, before the bolus. The administration of a weight-adjusted propofol bolus of 1.03 ± 0.31 mg/kg resulted in an increase in NFRT and burst-suppression ratio; BIS and electromyogram values decreased. Changes from baseline (95% CI) after propofol bolus administration were BIS -23.9 (-30.8 to -17.1), EMG -10.5 dB (-13.3 to -7.7), SR 14.8 % (5.6 to 24.0) and NFRT 13.6 mA (5.5 to 21.7). Further studies are needed to determine whether sedated children may benefit from objective pain and sedation monitoring with BIS and NFRT.

AB - We analyzed the impact of propofol administration during continuous sedation and analgesia on the nociceptive flexion reflex threshold (NFRT) and Bispectral Index (BIS) in ventilated children. We examined patients who received propofol before planned endotracheal suctioning. Patients were clinically assessed using the modified Face, Legs, Activity, Cry, Consolability (mFLACC) scale and COMFORT-B (Comfort Behavior) scale. We continuously recorded the NFRT and BIS. We recorded 23 propofol administrations in eight patients with an average age of 8.6 ± 3.5 years. The median (minimum-maximum) scores for the mFLACC scale and COMFORT-B scale were 0 (0-5) and 6 (6-17), respectively, before the bolus. The administration of a weight-adjusted propofol bolus of 1.03 ± 0.31 mg/kg resulted in an increase in NFRT and burst-suppression ratio; BIS and electromyogram values decreased. Changes from baseline (95% CI) after propofol bolus administration were BIS -23.9 (-30.8 to -17.1), EMG -10.5 dB (-13.3 to -7.7), SR 14.8 % (5.6 to 24.0) and NFRT 13.6 mA (5.5 to 21.7). Further studies are needed to determine whether sedated children may benefit from objective pain and sedation monitoring with BIS and NFRT.

U2 - 10.3390/children8080639

DO - 10.3390/children8080639

M3 - SCORING: Journal article

C2 - 34438531

VL - 8

SP - 639

JO - CHILDREN-BASEL

JF - CHILDREN-BASEL

SN - 2227-9067

IS - 8

ER -