Impact of prior imatinib mesylate on the outcome of hematopoietic cell transplantation for chronic myeloid leukemia.
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Impact of prior imatinib mesylate on the outcome of hematopoietic cell transplantation for chronic myeloid leukemia. / Lee, Stephanie J; Kukreja, Manisha; Wang, Tao; Giralt, Sergio A; Szer, Jeffrey; Arora, Mukta; Woolfrey, Ann E; Cervantes, Francisco; Champlin, Richard E; Gale, Robert Peter; Halter, Joerg; Keating, Armand; Marks, David I; McCarthy, Philip L; Olavarria, Eduardo; Stadtmauer, Edward A; Abecasis, Manuel; Gupta, Vikas; Khoury, H Jean; George, Biju; Hale, Gregory A; Liesveld, Jane L; Rizzieri, David A; Antin, Joseph H; Bolwell, Brian J; Carabasi, Matthew H; Copelan, Edward; Ilhan, Osman; Litzow, Mark R; Schouten, Harold C; Zander, Axel R.; Horowitz, Mary M; Maziarz, Richard T.
In: BLOOD, Vol. 112, No. 8, 8, 2008, p. 3500-3507.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Impact of prior imatinib mesylate on the outcome of hematopoietic cell transplantation for chronic myeloid leukemia.
AU - Lee, Stephanie J
AU - Kukreja, Manisha
AU - Wang, Tao
AU - Giralt, Sergio A
AU - Szer, Jeffrey
AU - Arora, Mukta
AU - Woolfrey, Ann E
AU - Cervantes, Francisco
AU - Champlin, Richard E
AU - Gale, Robert Peter
AU - Halter, Joerg
AU - Keating, Armand
AU - Marks, David I
AU - McCarthy, Philip L
AU - Olavarria, Eduardo
AU - Stadtmauer, Edward A
AU - Abecasis, Manuel
AU - Gupta, Vikas
AU - Khoury, H Jean
AU - George, Biju
AU - Hale, Gregory A
AU - Liesveld, Jane L
AU - Rizzieri, David A
AU - Antin, Joseph H
AU - Bolwell, Brian J
AU - Carabasi, Matthew H
AU - Copelan, Edward
AU - Ilhan, Osman
AU - Litzow, Mark R
AU - Schouten, Harold C
AU - Zander, Axel R.
AU - Horowitz, Mary M
AU - Maziarz, Richard T
PY - 2008
Y1 - 2008
N2 - Imatinib mesylate (IM, Gleevec) has largely supplanted allogeneic hematopoietic cell transplantation (HCT) as first line therapy for chronic myeloid leukemia (CML). Nevertheless, many people with CML eventually undergo HCT, raising the question of whether prior IM therapy impacts HCT success. Data from the Center for International Blood and Marrow Transplant Research on 409 subjects treated with IM before HCT (IM(+)) and 900 subjects who did not receive IM before HCT (IM(-)) were analyzed. Among patients in first chronic phase, IM therapy before HCT was associated with better survival but no statistically significant differences in treatment-related mortality, relapse, and leukemia-free survival. Better HLA-matched donors, use of bone marrow, and transplantation within one year of diagnosis were also associated with better survival. A matched-pairs analysis was performed and confirmed a higher survival rate among first chronic phase patients receiving IM. Among patients transplanted with advanced CML, use of IM before HCT was not associated with treatment-related mortality, relapse, leukemia-free survival, or survival. Acute graft-versus-host disease rates were similar between IM(+) and IM(-) groups regardless of leukemia phase. These results should be reassuring to patients receiving IM before HCT.
AB - Imatinib mesylate (IM, Gleevec) has largely supplanted allogeneic hematopoietic cell transplantation (HCT) as first line therapy for chronic myeloid leukemia (CML). Nevertheless, many people with CML eventually undergo HCT, raising the question of whether prior IM therapy impacts HCT success. Data from the Center for International Blood and Marrow Transplant Research on 409 subjects treated with IM before HCT (IM(+)) and 900 subjects who did not receive IM before HCT (IM(-)) were analyzed. Among patients in first chronic phase, IM therapy before HCT was associated with better survival but no statistically significant differences in treatment-related mortality, relapse, and leukemia-free survival. Better HLA-matched donors, use of bone marrow, and transplantation within one year of diagnosis were also associated with better survival. A matched-pairs analysis was performed and confirmed a higher survival rate among first chronic phase patients receiving IM. Among patients transplanted with advanced CML, use of IM before HCT was not associated with treatment-related mortality, relapse, leukemia-free survival, or survival. Acute graft-versus-host disease rates were similar between IM(+) and IM(-) groups regardless of leukemia phase. These results should be reassuring to patients receiving IM before HCT.
M3 - SCORING: Zeitschriftenaufsatz
VL - 112
SP - 3500
EP - 3507
JO - BLOOD
JF - BLOOD
SN - 0006-4971
IS - 8
M1 - 8
ER -
