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Impact of Myocardial Fibrosis on Left Ventricular Function Evaluated by Feature-Tracking Myocardial Strain Cardiac Magnetic Resonance in Competitive Male Triathletes With Normal Ejection Fraction

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Impact of Myocardial Fibrosis on Left Ventricular Function Evaluated by Feature-Tracking Myocardial Strain Cardiac Magnetic Resonance in Competitive Male Triathletes With Normal Ejection Fraction. / Tahir, Enver; Starekova, Jitka; Muellerleile, Kai; Freiwald, Eric; von Stritzky, Alexandra; Münch, Julia; Avanesov, Maxim; Weinrich, Julius Matthias; Stehning, Christian; Cavus, Ersin; Bohnen, Sebastian; Radunski, Ulf K; Blankenberg, Stefan; Adam, Gerhard; Simon, Perikles; Pressler, Axel; Patten, Monica; Lund, Gunnar K.

In: CIRC J, Vol. 83, No. 7, 25.06.2019, p. 1553-1562.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Tahir, E, Starekova, J, Muellerleile, K, Freiwald, E, von Stritzky, A, Münch, J, Avanesov, M, Weinrich, JM, Stehning, C, Cavus, E, Bohnen, S, Radunski, UK, Blankenberg, S, Adam, G, Simon, P, Pressler, A, Patten, M & Lund, GK 2019, 'Impact of Myocardial Fibrosis on Left Ventricular Function Evaluated by Feature-Tracking Myocardial Strain Cardiac Magnetic Resonance in Competitive Male Triathletes With Normal Ejection Fraction', CIRC J, vol. 83, no. 7, pp. 1553-1562. https://doi.org/10.1253/circj.CJ-18-1388

APA

Tahir, E., Starekova, J., Muellerleile, K., Freiwald, E., von Stritzky, A., Münch, J., Avanesov, M., Weinrich, J. M., Stehning, C., Cavus, E., Bohnen, S., Radunski, U. K., Blankenberg, S., Adam, G., Simon, P., Pressler, A., Patten, M., & Lund, G. K. (2019). Impact of Myocardial Fibrosis on Left Ventricular Function Evaluated by Feature-Tracking Myocardial Strain Cardiac Magnetic Resonance in Competitive Male Triathletes With Normal Ejection Fraction. CIRC J, 83(7), 1553-1562. https://doi.org/10.1253/circj.CJ-18-1388

Vancouver

Tahir E, Starekova J, Muellerleile K, Freiwald E, von Stritzky A, Münch J et al. Impact of Myocardial Fibrosis on Left Ventricular Function Evaluated by Feature-Tracking Myocardial Strain Cardiac Magnetic Resonance in Competitive Male Triathletes With Normal Ejection Fraction. CIRC J. 2019 Jun 25;83(7):1553-1562. https://doi.org/10.1253/circj.CJ-18-1388

Bibtex

@article{b16c4cc575b848719bb6dd9803a57d3e,
title = "Impact of Myocardial Fibrosis on Left Ventricular Function Evaluated by Feature-Tracking Myocardial Strain Cardiac Magnetic Resonance in Competitive Male Triathletes With Normal Ejection Fraction",
abstract = "BACKGROUND: To analyze the effect of myocardial fibrosis on left ventricular (LV) function evaluated by feature-tracking strain analysis by cine cardiac magnetic resonance (CMR) in competitive male triathletes with normal ejection fraction (EF).Methods and Results:78 asymptomatic male triathletes with >10 weekly training hours (43±11 years) and 28 male age-matched controls were studied by late gadolinium enhancement (LGE) and cine CMR. Global and segmental radial, longitudinal and circumferential strains were analyzed using feature-tracking cine CMR. Focal non-ischemic LGE was observed in 15 of 78 triathletes (19%, LGE+) with predominance in the basal inferolateral segments. LVEF was normal in LGE+ (62±6%) and LGE- triathletes (62±5%, P=0.958). In contrast, global radial strain was lower in LGE+ triathletes at 40±7% compared with LGE- triathletes (45±7%, P<0.05). Reduced segmental radial strain occurred either in LGE+ segments or in directly adjacent segments. Strain analysis revealed regional differences in controls, with the highest radial and longitudinal strain in the inferolateral segments, which were typically affected by fibrosis in LGE+ triathletes.CONCLUSIONS: Reduced global and regional radial strain suggests a negative effect of myocardial fibrosis on LV function in LGE+ triathletes with normal EF. The observed regional differences in controls with the highest radial and longitudinal strain in the inferolateral segments may explain the typical occurrence of fibrosis in this myocardial region in triathletes.",
author = "Enver Tahir and Jitka Starekova and Kai Muellerleile and Eric Freiwald and {von Stritzky}, Alexandra and Julia M{\"u}nch and Maxim Avanesov and Weinrich, {Julius Matthias} and Christian Stehning and Ersin Cavus and Sebastian Bohnen and Radunski, {Ulf K} and Stefan Blankenberg and Gerhard Adam and Perikles Simon and Axel Pressler and Monica Patten and Lund, {Gunnar K}",
year = "2019",
month = jun,
day = "25",
doi = "10.1253/circj.CJ-18-1388",
language = "English",
volume = "83",
pages = "1553--1562",
journal = "CIRC J",
issn = "1346-9843",
publisher = "Japanese Circulation Society",
number = "7",

}

RIS

TY - JOUR

T1 - Impact of Myocardial Fibrosis on Left Ventricular Function Evaluated by Feature-Tracking Myocardial Strain Cardiac Magnetic Resonance in Competitive Male Triathletes With Normal Ejection Fraction

AU - Tahir, Enver

AU - Starekova, Jitka

AU - Muellerleile, Kai

AU - Freiwald, Eric

AU - von Stritzky, Alexandra

AU - Münch, Julia

AU - Avanesov, Maxim

AU - Weinrich, Julius Matthias

AU - Stehning, Christian

AU - Cavus, Ersin

AU - Bohnen, Sebastian

AU - Radunski, Ulf K

AU - Blankenberg, Stefan

AU - Adam, Gerhard

AU - Simon, Perikles

AU - Pressler, Axel

AU - Patten, Monica

AU - Lund, Gunnar K

PY - 2019/6/25

Y1 - 2019/6/25

N2 - BACKGROUND: To analyze the effect of myocardial fibrosis on left ventricular (LV) function evaluated by feature-tracking strain analysis by cine cardiac magnetic resonance (CMR) in competitive male triathletes with normal ejection fraction (EF).Methods and Results:78 asymptomatic male triathletes with >10 weekly training hours (43±11 years) and 28 male age-matched controls were studied by late gadolinium enhancement (LGE) and cine CMR. Global and segmental radial, longitudinal and circumferential strains were analyzed using feature-tracking cine CMR. Focal non-ischemic LGE was observed in 15 of 78 triathletes (19%, LGE+) with predominance in the basal inferolateral segments. LVEF was normal in LGE+ (62±6%) and LGE- triathletes (62±5%, P=0.958). In contrast, global radial strain was lower in LGE+ triathletes at 40±7% compared with LGE- triathletes (45±7%, P<0.05). Reduced segmental radial strain occurred either in LGE+ segments or in directly adjacent segments. Strain analysis revealed regional differences in controls, with the highest radial and longitudinal strain in the inferolateral segments, which were typically affected by fibrosis in LGE+ triathletes.CONCLUSIONS: Reduced global and regional radial strain suggests a negative effect of myocardial fibrosis on LV function in LGE+ triathletes with normal EF. The observed regional differences in controls with the highest radial and longitudinal strain in the inferolateral segments may explain the typical occurrence of fibrosis in this myocardial region in triathletes.

AB - BACKGROUND: To analyze the effect of myocardial fibrosis on left ventricular (LV) function evaluated by feature-tracking strain analysis by cine cardiac magnetic resonance (CMR) in competitive male triathletes with normal ejection fraction (EF).Methods and Results:78 asymptomatic male triathletes with >10 weekly training hours (43±11 years) and 28 male age-matched controls were studied by late gadolinium enhancement (LGE) and cine CMR. Global and segmental radial, longitudinal and circumferential strains were analyzed using feature-tracking cine CMR. Focal non-ischemic LGE was observed in 15 of 78 triathletes (19%, LGE+) with predominance in the basal inferolateral segments. LVEF was normal in LGE+ (62±6%) and LGE- triathletes (62±5%, P=0.958). In contrast, global radial strain was lower in LGE+ triathletes at 40±7% compared with LGE- triathletes (45±7%, P<0.05). Reduced segmental radial strain occurred either in LGE+ segments or in directly adjacent segments. Strain analysis revealed regional differences in controls, with the highest radial and longitudinal strain in the inferolateral segments, which were typically affected by fibrosis in LGE+ triathletes.CONCLUSIONS: Reduced global and regional radial strain suggests a negative effect of myocardial fibrosis on LV function in LGE+ triathletes with normal EF. The observed regional differences in controls with the highest radial and longitudinal strain in the inferolateral segments may explain the typical occurrence of fibrosis in this myocardial region in triathletes.

U2 - 10.1253/circj.CJ-18-1388

DO - 10.1253/circj.CJ-18-1388

M3 - SCORING: Journal article

C2 - 31080228

VL - 83

SP - 1553

EP - 1562

JO - CIRC J

JF - CIRC J

SN - 1346-9843

IS - 7

ER -