Research ExplorerPublicationsImpact of Modern Low Dose Involved Site Radiation Therapy on...

Impact of Modern Low Dose Involved Site Radiation Therapy on Normal Tissue Toxicity in Cervicothoracic Non-Hodgkin Lymphomas: A Biophysical Study

Standard

Impact of Modern Low Dose Involved Site Radiation Therapy on Normal Tissue Toxicity in Cervicothoracic Non-Hodgkin Lymphomas: A Biophysical Study. / Roers, Julian; Rolf, Daniel; Baehr, Andrea; Pöttgen, Christoph; Stickan-Verfürth, Martina; Siats, Jan; Hering, Dominik A.; Moustakis, Christos; Grohmann, Maximilian; Oertel, Michael; Haverkamp, Uwe; Stuschke, Martin; Timmermann, Beate; Eich, Hans T.; Reinartz, Gabriele.

In: CANCERS, Vol. 15, No. 24, 5712, 05.12.2023.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Roers, J, Rolf, D, Baehr, A, Pöttgen, C, Stickan-Verfürth, M, Siats, J, Hering, DA, Moustakis, C, Grohmann, M, Oertel, M, Haverkamp, U, Stuschke, M, Timmermann, B, Eich, HT & Reinartz, G 2023, 'Impact of Modern Low Dose Involved Site Radiation Therapy on Normal Tissue Toxicity in Cervicothoracic Non-Hodgkin Lymphomas: A Biophysical Study', CANCERS, vol. 15, no. 24, 5712. https://doi.org/10.3390/cancers15245712

APA

Roers, J., Rolf, D., Baehr, A., Pöttgen, C., Stickan-Verfürth, M., Siats, J., Hering, D. A., Moustakis, C., Grohmann, M., Oertel, M., Haverkamp, U., Stuschke, M., Timmermann, B., Eich, H. T., & Reinartz, G. (2023). Impact of Modern Low Dose Involved Site Radiation Therapy on Normal Tissue Toxicity in Cervicothoracic Non-Hodgkin Lymphomas: A Biophysical Study. CANCERS, 15(24), [5712]. https://doi.org/10.3390/cancers15245712

Vancouver

Roers J, Rolf D, Baehr A, Pöttgen C, Stickan-Verfürth M, Siats J et al. Impact of Modern Low Dose Involved Site Radiation Therapy on Normal Tissue Toxicity in Cervicothoracic Non-Hodgkin Lymphomas: A Biophysical Study. CANCERS. 2023 Dec 5;15(24). 5712. https://doi.org/10.3390/cancers15245712

Bibtex

@article{17123c4e083948d4baac141e27771f90,
title = "Impact of Modern Low Dose Involved Site Radiation Therapy on Normal Tissue Toxicity in Cervicothoracic Non-Hodgkin Lymphomas: A Biophysical Study",
abstract = "This biophysical study aimed to determine fitting parameters for the Lyman–Kutcher–Burman (LKB) dose–response model for normal tissue complication probability (NTCP) calculations of acute side effects and to investigate the impact of reduced radiation doses on the probability of their occurrence in supradiaphragmatic non-Hodgkin lymphoma (NHL) irradiation. A cohort of 114 patients with NHL in the cervicothoracic region, treated between 2015 and 2021 at the University Hospitals of M{\"u}nster, Hamburg, and Essen, with involved site radiation therapy (ISRT), were included. Among them, 68 patients with aggressive NHL (a-NHL) received consolidative radiation therapy with 24–54 Gy following (R-)CHOP chemotherapy. Additionally, 46 patients with indolent NHL (i-NHL) underwent radiotherapy with 22.5–45.0 Gy. Two treatment plans were prospectively created for each patient (a-NHL: 30.0/40.0 Gy; i-NHL: 24.0/30.0 Gy). NTCP were then calculated using the optimized LKB model. The adapted dose–response models properly predicted the patient{\textquoteright}s probability of developing acute side effects when receiving doses ≤ 50 Gy. In addition, it was shown that reduced radiation doses can influence the NTCP of acute side effects depending on the aggressiveness of NHL significantly. This study provided a foundation to prospectively assess the probability of adverse side effects among today{\textquoteright}s reduced radiation doses in the treatment of NHL.",
keywords = "involved site radiation therapy, Lyman–Kutcher–Burman model, non-Hodgkin lymphoma, normal tissue toxicity, reduced radiation doses",
author = "Julian Roers and Daniel Rolf and Andrea Baehr and Christoph P{\"o}ttgen and Martina Stickan-Verf{\"u}rth and Jan Siats and Hering, {Dominik A.} and Christos Moustakis and Maximilian Grohmann and Michael Oertel and Uwe Haverkamp and Martin Stuschke and Beate Timmermann and Eich, {Hans T.} and Gabriele Reinartz",
year = "2023",
month = dec,
day = "5",
doi = "10.3390/cancers15245712",
language = "English",
volume = "15",
journal = "CANCERS",
issn = "2072-6694",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "24",

}

RIS

TY - JOUR

T1 - Impact of Modern Low Dose Involved Site Radiation Therapy on Normal Tissue Toxicity in Cervicothoracic Non-Hodgkin Lymphomas: A Biophysical Study

AU - Roers, Julian

AU - Rolf, Daniel

AU - Baehr, Andrea

AU - Pöttgen, Christoph

AU - Stickan-Verfürth, Martina

AU - Siats, Jan

AU - Hering, Dominik A.

AU - Moustakis, Christos

AU - Grohmann, Maximilian

AU - Oertel, Michael

AU - Haverkamp, Uwe

AU - Stuschke, Martin

AU - Timmermann, Beate

AU - Eich, Hans T.

AU - Reinartz, Gabriele

PY - 2023/12/5

Y1 - 2023/12/5

N2 - This biophysical study aimed to determine fitting parameters for the Lyman–Kutcher–Burman (LKB) dose–response model for normal tissue complication probability (NTCP) calculations of acute side effects and to investigate the impact of reduced radiation doses on the probability of their occurrence in supradiaphragmatic non-Hodgkin lymphoma (NHL) irradiation. A cohort of 114 patients with NHL in the cervicothoracic region, treated between 2015 and 2021 at the University Hospitals of Münster, Hamburg, and Essen, with involved site radiation therapy (ISRT), were included. Among them, 68 patients with aggressive NHL (a-NHL) received consolidative radiation therapy with 24–54 Gy following (R-)CHOP chemotherapy. Additionally, 46 patients with indolent NHL (i-NHL) underwent radiotherapy with 22.5–45.0 Gy. Two treatment plans were prospectively created for each patient (a-NHL: 30.0/40.0 Gy; i-NHL: 24.0/30.0 Gy). NTCP were then calculated using the optimized LKB model. The adapted dose–response models properly predicted the patient’s probability of developing acute side effects when receiving doses ≤ 50 Gy. In addition, it was shown that reduced radiation doses can influence the NTCP of acute side effects depending on the aggressiveness of NHL significantly. This study provided a foundation to prospectively assess the probability of adverse side effects among today’s reduced radiation doses in the treatment of NHL.

AB - This biophysical study aimed to determine fitting parameters for the Lyman–Kutcher–Burman (LKB) dose–response model for normal tissue complication probability (NTCP) calculations of acute side effects and to investigate the impact of reduced radiation doses on the probability of their occurrence in supradiaphragmatic non-Hodgkin lymphoma (NHL) irradiation. A cohort of 114 patients with NHL in the cervicothoracic region, treated between 2015 and 2021 at the University Hospitals of Münster, Hamburg, and Essen, with involved site radiation therapy (ISRT), were included. Among them, 68 patients with aggressive NHL (a-NHL) received consolidative radiation therapy with 24–54 Gy following (R-)CHOP chemotherapy. Additionally, 46 patients with indolent NHL (i-NHL) underwent radiotherapy with 22.5–45.0 Gy. Two treatment plans were prospectively created for each patient (a-NHL: 30.0/40.0 Gy; i-NHL: 24.0/30.0 Gy). NTCP were then calculated using the optimized LKB model. The adapted dose–response models properly predicted the patient’s probability of developing acute side effects when receiving doses ≤ 50 Gy. In addition, it was shown that reduced radiation doses can influence the NTCP of acute side effects depending on the aggressiveness of NHL significantly. This study provided a foundation to prospectively assess the probability of adverse side effects among today’s reduced radiation doses in the treatment of NHL.

KW - involved site radiation therapy

KW - Lyman–Kutcher–Burman model

KW - non-Hodgkin lymphoma

KW - normal tissue toxicity

KW - reduced radiation doses

U2 - 10.3390/cancers15245712

DO - 10.3390/cancers15245712

M3 - SCORING: Journal article

VL - 15

JO - CANCERS

JF - CANCERS

SN - 2072-6694

IS - 24

M1 - 5712

ER -