Impact of KIT and PDGFRA gene mutations on prognosis of patients with gastrointestinal stromal tumors after complete primary tumor resection.

Ying-Yong Hou; Florian Grabellus; Frank Weber; Yang Zhou; Yun-Shan Tan; Jun Li; Kun-Tang Shen; Jin Qin; Yi-Hong Sun; Xin-Yu Qin; Maximilian Bockhorn; Guido Gerken; Christoph E Broelsch; Andrea Frilling

Impact of KIT and PDGFRA gene mutations on prognosis of patients with gastrointestinal stromal tumors after complete primary tumor resection.

Standard

Impact of KIT and PDGFRA gene mutations on prognosis of patients with gastrointestinal stromal tumors after complete primary tumor resection. / Hou, Ying-Yong; Grabellus, Florian; Weber, Frank; Zhou, Yang; Tan, Yun-Shan; Li, Jun; Shen, Kun-Tang; Qin, Jin; Sun, Yi-Hong; Qin, Xin-Yu; Bockhorn, Maximilian; Gerken, Guido; Broelsch, Christoph E; Frilling, Andrea.

In: J GASTROINTEST SURG, Vol. 13, No. 9, 9, 2009, p. 1583-1592.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Hou, Y-Y, Grabellus, F, Weber, F, Zhou, Y, Tan, Y-S, Li, J, Shen, K-T, Qin, J, Sun, Y-H, Qin, X-Y, Bockhorn, M, Gerken, G, Broelsch, CE & Frilling, A 2009, 'Impact of KIT and PDGFRA gene mutations on prognosis of patients with gastrointestinal stromal tumors after complete primary tumor resection.', J GASTROINTEST SURG, vol. 13, no. 9, 9, pp. 1583-1592. <http://www.ncbi.nlm.nih.gov/pubmed/19291337?dopt=Citation>

APA

Hou, Y-Y., Grabellus, F., Weber, F., Zhou, Y., Tan, Y-S., Li, J., Shen, K-T., Qin, J., Sun, Y-H., Qin, X-Y., Bockhorn, M., Gerken, G., Broelsch, C. E., & Frilling, A. (2009). Impact of KIT and PDGFRA gene mutations on prognosis of patients with gastrointestinal stromal tumors after complete primary tumor resection. J GASTROINTEST SURG, 13(9), 1583-1592. [9]. http://www.ncbi.nlm.nih.gov/pubmed/19291337?dopt=Citation

Vancouver

Hou Y-Y, Grabellus F, Weber F, Zhou Y, Tan Y-S, Li J et al. Impact of KIT and PDGFRA gene mutations on prognosis of patients with gastrointestinal stromal tumors after complete primary tumor resection. J GASTROINTEST SURG. 2009;13(9):1583-1592. 9.

Bibtex

@article{3616d7a6acba4fce89549e636cc85a54,

title = "Impact of KIT and PDGFRA gene mutations on prognosis of patients with gastrointestinal stromal tumors after complete primary tumor resection.",

abstract = "INTRODUCTION: To investigate the impact of KIT and PDGFRA gene mutations on the prognosis of gastrointestinal stromal tumors (GIST). MATERIAL AND METHODS: Tumor tissue from 184 patients with primary GIST was submitted to mutational analysis of exons 9, 11, 13, and 17 of the KIT gene and exons 12 and 18 of the PDGFRA gene. Clinical and pathological parameters were analyzed and correlated to the risk of recurrence and disease-free survival (DFS). RESULTS AND DISCUSSION: The authors found that somatic mutations were detected in 162 tumors (88.0%). Age, clinical stage, mitotic count, and tumor size were of prognostic relevance on both univariate and multivariate analysis. Five-year DFS was 41.9%. While the presence of a KIT or PDGFRA mutation per se was not associated with tumor recurrence and/or disease-free survival, exon 11 deletion and hemizygous mutation status were both independent factors highly predictive for poor survival. CONCLUSION: The authors conclude that KIT exon 11 deletions and somatic loss of the wild-type KIT identified patients with poor prognosis. Age, clinical stage, tumor size, and mitotic count were standard clinicopathologic features that significantly influenced the prognosis. Mutation type of the mitogen receptor c-kit has a potential for predicting the course of the disease and might contribute to management individualization of GIST patients.",

keywords = "Adult, Humans, Male, Aged, Female, Middle Aged, Aged, 80 and over, Adolescent, Young Adult, Multivariate Analysis, Registries, Biopsy, Needle, Immunohistochemistry, Prognosis, Risk Assessment, Survival Analysis, Disease-Free Survival, Proportional Hazards Models, Retrospective Studies, Mutation, Chi-Square Distribution, Digestive System Surgical Procedures methods, Gastrointestinal Stromal Tumors genetics, Gene Expression Regulation, Neoplastic, Genetic Predisposition to Disease epidemiology, Neoplasm Recurrence, Local genetics, Neoplasm Staging, Proto-Oncogene Proteins c-kit genetics, Receptor, Platelet-Derived Growth Factor alpha genetics, Adult, Humans, Male, Aged, Female, Middle Aged, Aged, 80 and over, Adolescent, Young Adult, Multivariate Analysis, Registries, Biopsy, Needle, Immunohistochemistry, Prognosis, Risk Assessment, Survival Analysis, Disease-Free Survival, Proportional Hazards Models, Retrospective Studies, Mutation, Chi-Square Distribution, Digestive System Surgical Procedures methods, Gastrointestinal Stromal Tumors genetics, Gene Expression Regulation, Neoplastic, Genetic Predisposition to Disease epidemiology, Neoplasm Recurrence, Local genetics, Neoplasm Staging, Proto-Oncogene Proteins c-kit genetics, Receptor, Platelet-Derived Growth Factor alpha genetics",

author = "Ying-Yong Hou and Florian Grabellus and Frank Weber and Yang Zhou and Yun-Shan Tan and Jun Li and Kun-Tang Shen and Jin Qin and Yi-Hong Sun and Xin-Yu Qin and Maximilian Bockhorn and Guido Gerken and Broelsch, {Christoph E} and Andrea Frilling",

year = "2009",

language = "Deutsch",

volume = "13",

pages = "1583--1592",

journal = "J GASTROINTEST SURG",

issn = "1091-255X",

publisher = "Springer New York",

number = "9",

}

RIS

TY - JOUR

T1 - Impact of KIT and PDGFRA gene mutations on prognosis of patients with gastrointestinal stromal tumors after complete primary tumor resection.

AU - Hou, Ying-Yong

AU - Grabellus, Florian

AU - Weber, Frank

AU - Zhou, Yang

AU - Tan, Yun-Shan

AU - Li, Jun

AU - Shen, Kun-Tang

AU - Qin, Jin

AU - Sun, Yi-Hong

AU - Qin, Xin-Yu

AU - Bockhorn, Maximilian

AU - Gerken, Guido

AU - Broelsch, Christoph E

AU - Frilling, Andrea

PY - 2009

Y1 - 2009

N2 - INTRODUCTION: To investigate the impact of KIT and PDGFRA gene mutations on the prognosis of gastrointestinal stromal tumors (GIST). MATERIAL AND METHODS: Tumor tissue from 184 patients with primary GIST was submitted to mutational analysis of exons 9, 11, 13, and 17 of the KIT gene and exons 12 and 18 of the PDGFRA gene. Clinical and pathological parameters were analyzed and correlated to the risk of recurrence and disease-free survival (DFS). RESULTS AND DISCUSSION: The authors found that somatic mutations were detected in 162 tumors (88.0%). Age, clinical stage, mitotic count, and tumor size were of prognostic relevance on both univariate and multivariate analysis. Five-year DFS was 41.9%. While the presence of a KIT or PDGFRA mutation per se was not associated with tumor recurrence and/or disease-free survival, exon 11 deletion and hemizygous mutation status were both independent factors highly predictive for poor survival. CONCLUSION: The authors conclude that KIT exon 11 deletions and somatic loss of the wild-type KIT identified patients with poor prognosis. Age, clinical stage, tumor size, and mitotic count were standard clinicopathologic features that significantly influenced the prognosis. Mutation type of the mitogen receptor c-kit has a potential for predicting the course of the disease and might contribute to management individualization of GIST patients.

AB - INTRODUCTION: To investigate the impact of KIT and PDGFRA gene mutations on the prognosis of gastrointestinal stromal tumors (GIST). MATERIAL AND METHODS: Tumor tissue from 184 patients with primary GIST was submitted to mutational analysis of exons 9, 11, 13, and 17 of the KIT gene and exons 12 and 18 of the PDGFRA gene. Clinical and pathological parameters were analyzed and correlated to the risk of recurrence and disease-free survival (DFS). RESULTS AND DISCUSSION: The authors found that somatic mutations were detected in 162 tumors (88.0%). Age, clinical stage, mitotic count, and tumor size were of prognostic relevance on both univariate and multivariate analysis. Five-year DFS was 41.9%. While the presence of a KIT or PDGFRA mutation per se was not associated with tumor recurrence and/or disease-free survival, exon 11 deletion and hemizygous mutation status were both independent factors highly predictive for poor survival. CONCLUSION: The authors conclude that KIT exon 11 deletions and somatic loss of the wild-type KIT identified patients with poor prognosis. Age, clinical stage, tumor size, and mitotic count were standard clinicopathologic features that significantly influenced the prognosis. Mutation type of the mitogen receptor c-kit has a potential for predicting the course of the disease and might contribute to management individualization of GIST patients.

KW - Adult

KW - Humans

KW - Male

KW - Aged

KW - Female

KW - Middle Aged

KW - Aged, 80 and over

KW - Adolescent

KW - Young Adult

KW - Multivariate Analysis

KW - Registries

KW - Biopsy, Needle

KW - Immunohistochemistry

KW - Prognosis

KW - Risk Assessment

KW - Survival Analysis

KW - Disease-Free Survival

KW - Proportional Hazards Models

KW - Retrospective Studies

KW - Mutation

KW - Chi-Square Distribution

KW - Digestive System Surgical Procedures methods

KW - Gastrointestinal Stromal Tumors genetics

KW - Gene Expression Regulation, Neoplastic

KW - Genetic Predisposition to Disease epidemiology

KW - Neoplasm Recurrence, Local genetics

KW - Neoplasm Staging

KW - Proto-Oncogene Proteins c-kit genetics

KW - Receptor, Platelet-Derived Growth Factor alpha genetics