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Impact of kidney function on mortality after transcatheter valve implantation in patients with severe aortic valvular stenosis

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Impact of kidney function on mortality after transcatheter valve implantation in patients with severe aortic valvular stenosis. / Voigtländer, Lisa; Schewel, Jury; Martin, Julia; Schewel, Dimitry; Frerker, Christian; Wohlmuth, Peter; Thielsen, Thomas; Kuck, Karl-Heinz; Schäfer, Ulrich.

In: INT J CARDIOL, Vol. 178, 15.01.2015, p. 275-281.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Voigtländer, L, Schewel, J, Martin, J, Schewel, D, Frerker, C, Wohlmuth, P, Thielsen, T, Kuck, K-H & Schäfer, U 2015, 'Impact of kidney function on mortality after transcatheter valve implantation in patients with severe aortic valvular stenosis', INT J CARDIOL, vol. 178, pp. 275-281. https://doi.org/10.1016/j.ijcard.2014.10.172

APA

Voigtländer, L., Schewel, J., Martin, J., Schewel, D., Frerker, C., Wohlmuth, P., Thielsen, T., Kuck, K-H., & Schäfer, U. (2015). Impact of kidney function on mortality after transcatheter valve implantation in patients with severe aortic valvular stenosis. INT J CARDIOL, 178, 275-281. https://doi.org/10.1016/j.ijcard.2014.10.172

Vancouver

Voigtländer L, Schewel J, Martin J, Schewel D, Frerker C, Wohlmuth P et al. Impact of kidney function on mortality after transcatheter valve implantation in patients with severe aortic valvular stenosis. INT J CARDIOL. 2015 Jan 15;178:275-281. https://doi.org/10.1016/j.ijcard.2014.10.172

Bibtex

@article{70bd8a47c507411c98b05f9053cf0249,
title = "Impact of kidney function on mortality after transcatheter valve implantation in patients with severe aortic valvular stenosis",
abstract = "AIMS: Transcatheter aortic valve implantation (TAVI) is an accepted alternative for patients with severe aortic valve stenosis who cannot undergo surgery. Acute kidney injury (AKI) is a serious complication in any invasive cardiovascular intervention. The objectives of the study were to determine (i) the influence of kidney function before TAVI and (ii) the impact of changes in kidney function after TAVI, including acute kidney injury (AKI), on mortality.METHODS AND RESULTS: A total of 540 patients undergoing TAVI were included. Patients were divided into three groups according to glomerular filtration rate (GFR) before TAVI (A: normal renal function i.e. GFR ≥60ml/min; B: impaired renal function i.e. GFR 30-59ml/min; C: severe impaired renal function i.e. GFR <30ml/min). Multivariate analysis showed a significant impact of GFR on mortality (p<0.0008). Subgroup analysis showed significant differences between the groups in 30-day (A: 5.4%, B: 9.0%, C: 25.0%) and 12-month mortality (A: 15.0%, B: 32.0%, C: 49%). Patients who had an increase in GFR after TAVI by more than 22% (p=0.0068) had an improved survival rate, whereas a decrease in GFR by more than 15% was associated with an increased mortality rate (p=0.0051). AKI occurred in 30 patients (5.6%), of which 22 patients (73.3%) died within 12months.CONCLUSION: Outcome is significantly related to pre-procedural kidney function. In addition, changes in kidney function after TAVI have a significant impact on mortality. Due to a very poor prognosis in patients with AKI, any effort to prevent this serious complication after TAVI needs to be taken.",
keywords = "Acute Kidney Injury/diagnosis, Aged, Aged, 80 and over, Aortic Valve Stenosis/diagnosis, Female, Humans, Kidney/physiology, Male, Retrospective Studies, Risk Factors, Severity of Illness Index, Transcatheter Aortic Valve Replacement/adverse effects, Treatment Outcome",
author = "Lisa Voigtl{\"a}nder and Jury Schewel and Julia Martin and Dimitry Schewel and Christian Frerker and Peter Wohlmuth and Thomas Thielsen and Karl-Heinz Kuck and Ulrich Sch{\"a}fer",
note = "Copyright {\textcopyright} 2014 Elsevier Ireland Ltd. All rights reserved.",
year = "2015",
month = jan,
day = "15",
doi = "10.1016/j.ijcard.2014.10.172",
language = "English",
volume = "178",
pages = "275--281",
journal = "INT J CARDIOL",
issn = "0167-5273",
publisher = "Elsevier Ireland Ltd",

}

RIS

TY - JOUR

T1 - Impact of kidney function on mortality after transcatheter valve implantation in patients with severe aortic valvular stenosis

AU - Voigtländer, Lisa

AU - Schewel, Jury

AU - Martin, Julia

AU - Schewel, Dimitry

AU - Frerker, Christian

AU - Wohlmuth, Peter

AU - Thielsen, Thomas

AU - Kuck, Karl-Heinz

AU - Schäfer, Ulrich

N1 - Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

PY - 2015/1/15

Y1 - 2015/1/15

N2 - AIMS: Transcatheter aortic valve implantation (TAVI) is an accepted alternative for patients with severe aortic valve stenosis who cannot undergo surgery. Acute kidney injury (AKI) is a serious complication in any invasive cardiovascular intervention. The objectives of the study were to determine (i) the influence of kidney function before TAVI and (ii) the impact of changes in kidney function after TAVI, including acute kidney injury (AKI), on mortality.METHODS AND RESULTS: A total of 540 patients undergoing TAVI were included. Patients were divided into three groups according to glomerular filtration rate (GFR) before TAVI (A: normal renal function i.e. GFR ≥60ml/min; B: impaired renal function i.e. GFR 30-59ml/min; C: severe impaired renal function i.e. GFR <30ml/min). Multivariate analysis showed a significant impact of GFR on mortality (p<0.0008). Subgroup analysis showed significant differences between the groups in 30-day (A: 5.4%, B: 9.0%, C: 25.0%) and 12-month mortality (A: 15.0%, B: 32.0%, C: 49%). Patients who had an increase in GFR after TAVI by more than 22% (p=0.0068) had an improved survival rate, whereas a decrease in GFR by more than 15% was associated with an increased mortality rate (p=0.0051). AKI occurred in 30 patients (5.6%), of which 22 patients (73.3%) died within 12months.CONCLUSION: Outcome is significantly related to pre-procedural kidney function. In addition, changes in kidney function after TAVI have a significant impact on mortality. Due to a very poor prognosis in patients with AKI, any effort to prevent this serious complication after TAVI needs to be taken.

AB - AIMS: Transcatheter aortic valve implantation (TAVI) is an accepted alternative for patients with severe aortic valve stenosis who cannot undergo surgery. Acute kidney injury (AKI) is a serious complication in any invasive cardiovascular intervention. The objectives of the study were to determine (i) the influence of kidney function before TAVI and (ii) the impact of changes in kidney function after TAVI, including acute kidney injury (AKI), on mortality.METHODS AND RESULTS: A total of 540 patients undergoing TAVI were included. Patients were divided into three groups according to glomerular filtration rate (GFR) before TAVI (A: normal renal function i.e. GFR ≥60ml/min; B: impaired renal function i.e. GFR 30-59ml/min; C: severe impaired renal function i.e. GFR <30ml/min). Multivariate analysis showed a significant impact of GFR on mortality (p<0.0008). Subgroup analysis showed significant differences between the groups in 30-day (A: 5.4%, B: 9.0%, C: 25.0%) and 12-month mortality (A: 15.0%, B: 32.0%, C: 49%). Patients who had an increase in GFR after TAVI by more than 22% (p=0.0068) had an improved survival rate, whereas a decrease in GFR by more than 15% was associated with an increased mortality rate (p=0.0051). AKI occurred in 30 patients (5.6%), of which 22 patients (73.3%) died within 12months.CONCLUSION: Outcome is significantly related to pre-procedural kidney function. In addition, changes in kidney function after TAVI have a significant impact on mortality. Due to a very poor prognosis in patients with AKI, any effort to prevent this serious complication after TAVI needs to be taken.

KW - Acute Kidney Injury/diagnosis

KW - Aged

KW - Aged, 80 and over

KW - Aortic Valve Stenosis/diagnosis

KW - Female

KW - Humans

KW - Kidney/physiology

KW - Male

KW - Retrospective Studies

KW - Risk Factors

KW - Severity of Illness Index

KW - Transcatheter Aortic Valve Replacement/adverse effects

KW - Treatment Outcome

U2 - 10.1016/j.ijcard.2014.10.172

DO - 10.1016/j.ijcard.2014.10.172

M3 - SCORING: Journal article

C2 - 25464269

VL - 178

SP - 275

EP - 281

JO - INT J CARDIOL

JF - INT J CARDIOL

SN - 0167-5273

ER -