Impact of IDH1 R132 mutations and an IDH1 single nucleotide polymorphism in cytogenetically normal acute myeloid leukemia: SNP rs11554137 is an adverse prognostic factor.

  • Katharina Wagner
  • Frederik Damm
  • Gudrun Göhring
  • Kerstin Görlich
  • Michael Heuser
  • Irina Schäfer
  • Oliver Ottmann
  • Michael Lübbert
  • Wolfgang Heit
  • Lothar Kanz
  • Günter Schlimok
  • Aruna A Raghavachar
  • Walter Fiedler
  • Hartmut H Kirchner
  • Wolfram Brugger
  • Manuela Zucknick
  • Brigitte Schlegelberger
  • Gerhard Heil
  • Arnold Ganser
  • Jürgen Krauter

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Abstract

We assessed the prognostic impact of IDH1 R132 mutations and a known single nucleotide polymorphism (SNP) located in the same exon of the IDH1 gene in patients with cytogenetically normal acute myeloid leukemia (CN-AML) in the context of other prognostic markers.

Bibliographical data

Original languageGerman
Article number14
ISSN0732-183X
Publication statusPublished - 2010
pubmed 20368538