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Impact of HIV infection and antiretroviral treatment on N-terminal prohormone of brain natriuretic peptide as surrogate of myocardial function

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Impact of HIV infection and antiretroviral treatment on N-terminal prohormone of brain natriuretic peptide as surrogate of myocardial function. / Schuster, Christopher; Binder, Christina; Strassl, Robert; Aichelburg, Maximilian C; Blackwell, Emma; Pavo, Noemi; Ramharter, Michael; Hülsmann, Martin; Grabmeier-Pfistershammer, Katharina; Rieger, Armin; Goliasch, Georg.

In: AIDS, Vol. 31, No. 3, 28.01.2017, p. 395-400.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Schuster, C, Binder, C, Strassl, R, Aichelburg, MC, Blackwell, E, Pavo, N, Ramharter, M, Hülsmann, M, Grabmeier-Pfistershammer, K, Rieger, A & Goliasch, G 2017, 'Impact of HIV infection and antiretroviral treatment on N-terminal prohormone of brain natriuretic peptide as surrogate of myocardial function', AIDS, vol. 31, no. 3, pp. 395-400. https://doi.org/10.1097/QAD.0000000000001350

APA

Schuster, C., Binder, C., Strassl, R., Aichelburg, M. C., Blackwell, E., Pavo, N., Ramharter, M., Hülsmann, M., Grabmeier-Pfistershammer, K., Rieger, A., & Goliasch, G. (2017). Impact of HIV infection and antiretroviral treatment on N-terminal prohormone of brain natriuretic peptide as surrogate of myocardial function. AIDS, 31(3), 395-400. https://doi.org/10.1097/QAD.0000000000001350

Vancouver

Schuster C, Binder C, Strassl R, Aichelburg MC, Blackwell E, Pavo N et al. Impact of HIV infection and antiretroviral treatment on N-terminal prohormone of brain natriuretic peptide as surrogate of myocardial function. AIDS. 2017 Jan 28;31(3):395-400. https://doi.org/10.1097/QAD.0000000000001350

Bibtex

@article{cd5f405344b44f22ba4f8ec6b740b613,
title = "Impact of HIV infection and antiretroviral treatment on N-terminal prohormone of brain natriuretic peptide as surrogate of myocardial function",
abstract = "OBJECTIVE: Vasoactive cardiovascular hormones such as the N-terminal prohormone of brain natriuretic peptide (NT-proBNP) are produced upon ventricular stretch and play a central role in neurohumoral pathways of the heart regulating cardiovascular remodeling and volume homeostasis. The impact of HIV infection on these neurohumoral pathways of the heart and its potential reversibility by combinations of antiretroviral therapies remain unclear.METHODS: We assessed serum levels of NT-proBNP in 219 antiretroviral therapy-na{\"i}ve HIV-infected patients with a normal cardiac and renal status at treatment initiation and after attainment of viremic control.RESULTS: Before antiretroviral therapy, NT-proBNP as a surrogate of myocardial function displayed a significant correlation with absolute CD4 cell count (r = -0.31; P < 0.001) as well as with HIV viral load (r = 0.26; P < 0.001). The median levels of NT-proBNP were 80 pg/ml (36-205) in patients with a CD4 cell count less than 200 cells/μl and 42 pg/ml (20-80; P < 0.001) with a CD4 cell count more than 500 cells/μl. After viremic control, no statistical correlation was present.CONCLUSION: Higher NT-proBNP levels were observed in treatment-na{\"i}ve patients with low CD4 cell count and high HIV viral load, indicating a subclinical impact of HIV infection on myocardial function. This association is reversible by the initiation of antiretroviral therapy and subsequent viral suppression.",
keywords = "Adult, Anti-Retroviral Agents/therapeutic use, Biomarkers/blood, CD4 Lymphocyte Count, Cardiomyopathies/diagnosis, Female, HIV Infections/complications, Humans, Male, Middle Aged, Natriuretic Peptide, Brain/blood, Peptide Fragments/blood, Viral Load",
author = "Christopher Schuster and Christina Binder and Robert Strassl and Aichelburg, {Maximilian C} and Emma Blackwell and Noemi Pavo and Michael Ramharter and Martin H{\"u}lsmann and Katharina Grabmeier-Pfistershammer and Armin Rieger and Georg Goliasch",
year = "2017",
month = jan,
day = "28",
doi = "10.1097/QAD.0000000000001350",
language = "English",
volume = "31",
pages = "395--400",
journal = "AIDS",
issn = "0269-9370",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

RIS

TY - JOUR

T1 - Impact of HIV infection and antiretroviral treatment on N-terminal prohormone of brain natriuretic peptide as surrogate of myocardial function

AU - Schuster, Christopher

AU - Binder, Christina

AU - Strassl, Robert

AU - Aichelburg, Maximilian C

AU - Blackwell, Emma

AU - Pavo, Noemi

AU - Ramharter, Michael

AU - Hülsmann, Martin

AU - Grabmeier-Pfistershammer, Katharina

AU - Rieger, Armin

AU - Goliasch, Georg

PY - 2017/1/28

Y1 - 2017/1/28

N2 - OBJECTIVE: Vasoactive cardiovascular hormones such as the N-terminal prohormone of brain natriuretic peptide (NT-proBNP) are produced upon ventricular stretch and play a central role in neurohumoral pathways of the heart regulating cardiovascular remodeling and volume homeostasis. The impact of HIV infection on these neurohumoral pathways of the heart and its potential reversibility by combinations of antiretroviral therapies remain unclear.METHODS: We assessed serum levels of NT-proBNP in 219 antiretroviral therapy-naïve HIV-infected patients with a normal cardiac and renal status at treatment initiation and after attainment of viremic control.RESULTS: Before antiretroviral therapy, NT-proBNP as a surrogate of myocardial function displayed a significant correlation with absolute CD4 cell count (r = -0.31; P < 0.001) as well as with HIV viral load (r = 0.26; P < 0.001). The median levels of NT-proBNP were 80 pg/ml (36-205) in patients with a CD4 cell count less than 200 cells/μl and 42 pg/ml (20-80; P < 0.001) with a CD4 cell count more than 500 cells/μl. After viremic control, no statistical correlation was present.CONCLUSION: Higher NT-proBNP levels were observed in treatment-naïve patients with low CD4 cell count and high HIV viral load, indicating a subclinical impact of HIV infection on myocardial function. This association is reversible by the initiation of antiretroviral therapy and subsequent viral suppression.

AB - OBJECTIVE: Vasoactive cardiovascular hormones such as the N-terminal prohormone of brain natriuretic peptide (NT-proBNP) are produced upon ventricular stretch and play a central role in neurohumoral pathways of the heart regulating cardiovascular remodeling and volume homeostasis. The impact of HIV infection on these neurohumoral pathways of the heart and its potential reversibility by combinations of antiretroviral therapies remain unclear.METHODS: We assessed serum levels of NT-proBNP in 219 antiretroviral therapy-naïve HIV-infected patients with a normal cardiac and renal status at treatment initiation and after attainment of viremic control.RESULTS: Before antiretroviral therapy, NT-proBNP as a surrogate of myocardial function displayed a significant correlation with absolute CD4 cell count (r = -0.31; P < 0.001) as well as with HIV viral load (r = 0.26; P < 0.001). The median levels of NT-proBNP were 80 pg/ml (36-205) in patients with a CD4 cell count less than 200 cells/μl and 42 pg/ml (20-80; P < 0.001) with a CD4 cell count more than 500 cells/μl. After viremic control, no statistical correlation was present.CONCLUSION: Higher NT-proBNP levels were observed in treatment-naïve patients with low CD4 cell count and high HIV viral load, indicating a subclinical impact of HIV infection on myocardial function. This association is reversible by the initiation of antiretroviral therapy and subsequent viral suppression.

KW - Adult

KW - Anti-Retroviral Agents/therapeutic use

KW - Biomarkers/blood

KW - CD4 Lymphocyte Count

KW - Cardiomyopathies/diagnosis

KW - Female

KW - HIV Infections/complications

KW - Humans

KW - Male

KW - Middle Aged

KW - Natriuretic Peptide, Brain/blood

KW - Peptide Fragments/blood

KW - Viral Load

U2 - 10.1097/QAD.0000000000001350

DO - 10.1097/QAD.0000000000001350

M3 - SCORING: Journal article

C2 - 28081038

VL - 31

SP - 395

EP - 400

JO - AIDS

JF - AIDS

SN - 0269-9370

IS - 3

ER -