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Impact of histological variants on oncological outcomes of patients with urothelial carcinoma of the bladder treated with radical cystectomy

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Impact of histological variants on oncological outcomes of patients with urothelial carcinoma of the bladder treated with radical cystectomy. / Xylinas, Evanguelos; Rink, Michael; Robinson, Brian D; Lotan, Yair; Babjuk, Marek; Brisuda, Antonin; Green, David A; Kluth, Luis A; Pycha, Armin; Fradet, Yves; Faison, Talia; Lee, Richard K; Karakiewicz, Pierre I; Zerbib, Marc; Scherr, Douglas S; Shariat, Shahrokh F.

In: EUR J CANCER, Vol. 49, No. 8, 01.05.2013, p. 1889-97.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Xylinas, E, Rink, M, Robinson, BD, Lotan, Y, Babjuk, M, Brisuda, A, Green, DA, Kluth, LA, Pycha, A, Fradet, Y, Faison, T, Lee, RK, Karakiewicz, PI, Zerbib, M, Scherr, DS & Shariat, SF 2013, 'Impact of histological variants on oncological outcomes of patients with urothelial carcinoma of the bladder treated with radical cystectomy', EUR J CANCER, vol. 49, no. 8, pp. 1889-97. https://doi.org/10.1016/j.ejca.2013.02.001

APA

Xylinas, E., Rink, M., Robinson, B. D., Lotan, Y., Babjuk, M., Brisuda, A., Green, D. A., Kluth, L. A., Pycha, A., Fradet, Y., Faison, T., Lee, R. K., Karakiewicz, P. I., Zerbib, M., Scherr, D. S., & Shariat, S. F. (2013). Impact of histological variants on oncological outcomes of patients with urothelial carcinoma of the bladder treated with radical cystectomy. EUR J CANCER, 49(8), 1889-97. https://doi.org/10.1016/j.ejca.2013.02.001

Vancouver

Xylinas E, Rink M, Robinson BD, Lotan Y, Babjuk M, Brisuda A et al. Impact of histological variants on oncological outcomes of patients with urothelial carcinoma of the bladder treated with radical cystectomy. EUR J CANCER. 2013 May 1;49(8):1889-97. https://doi.org/10.1016/j.ejca.2013.02.001

Bibtex

@article{e92f80c82b64477cba385c184434e530,
title = "Impact of histological variants on oncological outcomes of patients with urothelial carcinoma of the bladder treated with radical cystectomy",
abstract = "OBJECTIVE: To investigate the impact of variant histologies of urothelial carcinoma of the bladder (UCB) on oncologic outcomes after radical cystectomy (RC).MATERIALS AND METHODS: Data from 1984 UCB patients treated by RC without preoperative chemo- or radiotherapy were reviewed for histological differentiation and variants. We analysed the differences between pure UCB and UCB with variant histology, and those between the different histological variants using various stratifications.RESULTS: Overall, 488 (24.6%) patients had UCB variants with squamous cell (11.4%) and glandular differentiation (3.8%) being the most common. Histological UCB variants were associated with advanced tumour stage, lymphovascular invasion and lymph node metastasis (all p-values<0.01) when compared to pure UCB. In univariable analyses, patients with non-squamous UCB variants were at significantly higher risk for disease recurrence and cancer-specific mortality than those with pure UCB patients (p-values=0.001) and those with squamous cell differentiated UCB (p-values=0.04); the latter two had the same risk. In multivariable analyses that adjusted for the effects of standard clinicopathologic characteristics, variant UCB histology was not associated with both survival end-points. In patients treated with adjuvant chemotherapy (n=492) there was no difference in cancer-specific survival between pure UCB, squamous cell differentiated UCB and other histological UCB variants.CONCLUSIONS: A quarter of UCB patients treated with RC harboured histological UCB variants. Variant UCB histologies were associated with features of biologically aggressive disease. While variant UCB histology was associated with worse outcomes in univariable analyses, this effect did not remain significant in multivariable analyses.",
keywords = "Aged, Carcinoma, Transitional Cell, Cystectomy, Female, Humans, Kaplan-Meier Estimate, Lymphatic Metastasis, Male, Middle Aged, Multivariate Analysis, Neoplasm Recurrence, Local, Neoplasm Staging, Outcome Assessment (Health Care), Prognosis, Proportional Hazards Models, Survival Rate, Urinary Bladder, Urinary Bladder Neoplasms",
author = "Evanguelos Xylinas and Michael Rink and Robinson, {Brian D} and Yair Lotan and Marek Babjuk and Antonin Brisuda and Green, {David A} and Kluth, {Luis A} and Armin Pycha and Yves Fradet and Talia Faison and Lee, {Richard K} and Karakiewicz, {Pierre I} and Marc Zerbib and Scherr, {Douglas S} and Shariat, {Shahrokh F}",
note = "Copyright {\textcopyright} 2013 Elsevier Ltd. All rights reserved.",
year = "2013",
month = may,
day = "1",
doi = "10.1016/j.ejca.2013.02.001",
language = "English",
volume = "49",
pages = "1889--97",
journal = "EUR J CANCER",
issn = "0959-8049",
publisher = "Elsevier Limited",
number = "8",

}

RIS

TY - JOUR

T1 - Impact of histological variants on oncological outcomes of patients with urothelial carcinoma of the bladder treated with radical cystectomy

AU - Xylinas, Evanguelos

AU - Rink, Michael

AU - Robinson, Brian D

AU - Lotan, Yair

AU - Babjuk, Marek

AU - Brisuda, Antonin

AU - Green, David A

AU - Kluth, Luis A

AU - Pycha, Armin

AU - Fradet, Yves

AU - Faison, Talia

AU - Lee, Richard K

AU - Karakiewicz, Pierre I

AU - Zerbib, Marc

AU - Scherr, Douglas S

AU - Shariat, Shahrokh F

N1 - Copyright © 2013 Elsevier Ltd. All rights reserved.

PY - 2013/5/1

Y1 - 2013/5/1

N2 - OBJECTIVE: To investigate the impact of variant histologies of urothelial carcinoma of the bladder (UCB) on oncologic outcomes after radical cystectomy (RC).MATERIALS AND METHODS: Data from 1984 UCB patients treated by RC without preoperative chemo- or radiotherapy were reviewed for histological differentiation and variants. We analysed the differences between pure UCB and UCB with variant histology, and those between the different histological variants using various stratifications.RESULTS: Overall, 488 (24.6%) patients had UCB variants with squamous cell (11.4%) and glandular differentiation (3.8%) being the most common. Histological UCB variants were associated with advanced tumour stage, lymphovascular invasion and lymph node metastasis (all p-values<0.01) when compared to pure UCB. In univariable analyses, patients with non-squamous UCB variants were at significantly higher risk for disease recurrence and cancer-specific mortality than those with pure UCB patients (p-values=0.001) and those with squamous cell differentiated UCB (p-values=0.04); the latter two had the same risk. In multivariable analyses that adjusted for the effects of standard clinicopathologic characteristics, variant UCB histology was not associated with both survival end-points. In patients treated with adjuvant chemotherapy (n=492) there was no difference in cancer-specific survival between pure UCB, squamous cell differentiated UCB and other histological UCB variants.CONCLUSIONS: A quarter of UCB patients treated with RC harboured histological UCB variants. Variant UCB histologies were associated with features of biologically aggressive disease. While variant UCB histology was associated with worse outcomes in univariable analyses, this effect did not remain significant in multivariable analyses.

AB - OBJECTIVE: To investigate the impact of variant histologies of urothelial carcinoma of the bladder (UCB) on oncologic outcomes after radical cystectomy (RC).MATERIALS AND METHODS: Data from 1984 UCB patients treated by RC without preoperative chemo- or radiotherapy were reviewed for histological differentiation and variants. We analysed the differences between pure UCB and UCB with variant histology, and those between the different histological variants using various stratifications.RESULTS: Overall, 488 (24.6%) patients had UCB variants with squamous cell (11.4%) and glandular differentiation (3.8%) being the most common. Histological UCB variants were associated with advanced tumour stage, lymphovascular invasion and lymph node metastasis (all p-values<0.01) when compared to pure UCB. In univariable analyses, patients with non-squamous UCB variants were at significantly higher risk for disease recurrence and cancer-specific mortality than those with pure UCB patients (p-values=0.001) and those with squamous cell differentiated UCB (p-values=0.04); the latter two had the same risk. In multivariable analyses that adjusted for the effects of standard clinicopathologic characteristics, variant UCB histology was not associated with both survival end-points. In patients treated with adjuvant chemotherapy (n=492) there was no difference in cancer-specific survival between pure UCB, squamous cell differentiated UCB and other histological UCB variants.CONCLUSIONS: A quarter of UCB patients treated with RC harboured histological UCB variants. Variant UCB histologies were associated with features of biologically aggressive disease. While variant UCB histology was associated with worse outcomes in univariable analyses, this effect did not remain significant in multivariable analyses.

KW - Aged

KW - Carcinoma, Transitional Cell

KW - Cystectomy

KW - Female

KW - Humans

KW - Kaplan-Meier Estimate

KW - Lymphatic Metastasis

KW - Male

KW - Middle Aged

KW - Multivariate Analysis

KW - Neoplasm Recurrence, Local

KW - Neoplasm Staging

KW - Outcome Assessment (Health Care)

KW - Prognosis

KW - Proportional Hazards Models

KW - Survival Rate

KW - Urinary Bladder

KW - Urinary Bladder Neoplasms

U2 - 10.1016/j.ejca.2013.02.001

DO - 10.1016/j.ejca.2013.02.001

M3 - SCORING: Journal article

C2 - 23466126

VL - 49

SP - 1889

EP - 1897

JO - EUR J CANCER

JF - EUR J CANCER

SN - 0959-8049

IS - 8

ER -