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Impact of histologic subtype on cancer-specific survival in patients with renal cell carcinoma and tumor thrombus

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Impact of histologic subtype on cancer-specific survival in patients with renal cell carcinoma and tumor thrombus. / Tilki, Derya; Nguyen, Hao G; Dall'Era, Marc A; Bertini, Roberto; Carballido, Joaquín A; Chromecki, Thomas; Ciancio, Gaetano; Daneshmand, Siamak; Gontero, Paolo; Gonzalez, Javier; Haferkamp, Axel; Hohenfellner, Markus; Huang, William C; Koppie, Theresa M; Lorentz, C Adam; Mandel, Philipp; Martinez-Salamanca, Juan I; Master, Viraj A; Matloob, Rayan; McKiernan, James M; Mlynarczyk, Carrie M; Montorsi, Francesco; Novara, Giacomo; Pahernik, Sascha; Palou, Juan; Pruthi, Raj S; Ramaswamy, Krishna; Rodriguez Faba, Oscar; Russo, Paul; Shariat, Shahrokh F; Spahn, Martin; Terrone, Carlo; Vergho, Daniel; Wallen, Eric M; Xylinas, Evanguelos; Zigeuner, Richard; Libertino, John A; Evans, Christopher P.

In: EUR UROL, Vol. 66, No. 3, 09.2014, p. 577-83.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Tilki, D, Nguyen, HG, Dall'Era, MA, Bertini, R, Carballido, JA, Chromecki, T, Ciancio, G, Daneshmand, S, Gontero, P, Gonzalez, J, Haferkamp, A, Hohenfellner, M, Huang, WC, Koppie, TM, Lorentz, CA, Mandel, P, Martinez-Salamanca, JI, Master, VA, Matloob, R, McKiernan, JM, Mlynarczyk, CM, Montorsi, F, Novara, G, Pahernik, S, Palou, J, Pruthi, RS, Ramaswamy, K, Rodriguez Faba, O, Russo, P, Shariat, SF, Spahn, M, Terrone, C, Vergho, D, Wallen, EM, Xylinas, E, Zigeuner, R, Libertino, JA & Evans, CP 2014, 'Impact of histologic subtype on cancer-specific survival in patients with renal cell carcinoma and tumor thrombus', EUR UROL, vol. 66, no. 3, pp. 577-83. https://doi.org/10.1016/j.eururo.2013.06.048

APA

Tilki, D., Nguyen, H. G., Dall'Era, M. A., Bertini, R., Carballido, J. A., Chromecki, T., Ciancio, G., Daneshmand, S., Gontero, P., Gonzalez, J., Haferkamp, A., Hohenfellner, M., Huang, W. C., Koppie, T. M., Lorentz, C. A., Mandel, P., Martinez-Salamanca, J. I., Master, V. A., Matloob, R., ... Evans, C. P. (2014). Impact of histologic subtype on cancer-specific survival in patients with renal cell carcinoma and tumor thrombus. EUR UROL, 66(3), 577-83. https://doi.org/10.1016/j.eururo.2013.06.048

Vancouver

Tilki D, Nguyen HG, Dall'Era MA, Bertini R, Carballido JA, Chromecki T et al. Impact of histologic subtype on cancer-specific survival in patients with renal cell carcinoma and tumor thrombus. EUR UROL. 2014 Sep;66(3):577-83. https://doi.org/10.1016/j.eururo.2013.06.048

Bibtex

@article{49e107be1ef2451fb8f210fa632e9c46,
title = "Impact of histologic subtype on cancer-specific survival in patients with renal cell carcinoma and tumor thrombus",
abstract = "BACKGROUND: Although different prognostic factors for patients with renal cell carcinoma (RCC) and vena cava tumor thrombus (TT) have been studied, the prognostic value of histologic subtype in these patients remains unclear.OBJECTIVE: We analyzed the impact of histologic subtype on cancer-specific survival (CSS).DESIGN, SETTINGS, AND PARTICIPANTS: We retrospectively analyzed the records of 1774 patients with RCC and TT who underwent radical nephrectomy and tumor thrombectomy from 1971 to 2012 at 22 US and European centers.OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: Multivariable ordered logistic and Cox regression models were used to quantify the impact of tumor histology on CSS.RESULTS AND LIMITATIONS: Overall 5-yr CSS was 53.4% (confidence interval [CI], 50.5-56.2) in the entire group. TT level (according to the Mayo classification of macroscopic venous invasion in RCC) was I in 38.5% of patients, II in 30.6%, III in 17.3%, and IV in 13.5%. Histologic subtypes were clear cell renal cell carcinoma (cRCC) in 89.9% of patients, papillary renal cell carcinoma (pRCC) in 8.5%, and chromophobe RCC in 1.6%. In univariable analysis, pRCC was associated with a significantly worse CSS (p<0.001) compared with cRCC. In multivariable analysis, the presence of pRCC was independently associated with CSS (hazard ratio: 1.62; CI, 1.01-2.61; p<0.05). Higher TT level, positive lymph node status, distant metastasis, and fat invasion were also independently associated with CSS.CONCLUSIONS: In our multi-institutional series, we found that patients with pRCC and vena cava TT who underwent radical nephrectomy and tumor thrombectomy had significantly worse cancer-specific outcomes when compared with patients with other histologic subtypes of RCC. We confirmed that higher TT level and fat invasion were independently associated with reduced CSS.",
keywords = "Adipose Tissue, Adult, Aged, Aged, 80 and over, Carcinoma, Renal Cell, Female, Humans, Kidney Neoplasms, Lymphatic Metastasis, Male, Middle Aged, Neoplasm Invasiveness, Nephrectomy, Prognosis, Retrospective Studies, Severity of Illness Index, Survival Rate, Venae Cavae, Venous Thrombosis, Young Adult, Journal Article",
author = "Derya Tilki and Nguyen, {Hao G} and Dall'Era, {Marc A} and Roberto Bertini and Carballido, {Joaqu{\'i}n A} and Thomas Chromecki and Gaetano Ciancio and Siamak Daneshmand and Paolo Gontero and Javier Gonzalez and Axel Haferkamp and Markus Hohenfellner and Huang, {William C} and Koppie, {Theresa M} and Lorentz, {C Adam} and Philipp Mandel and Martinez-Salamanca, {Juan I} and Master, {Viraj A} and Rayan Matloob and McKiernan, {James M} and Mlynarczyk, {Carrie M} and Francesco Montorsi and Giacomo Novara and Sascha Pahernik and Juan Palou and Pruthi, {Raj S} and Krishna Ramaswamy and {Rodriguez Faba}, Oscar and Paul Russo and Shariat, {Shahrokh F} and Martin Spahn and Carlo Terrone and Daniel Vergho and Wallen, {Eric M} and Evanguelos Xylinas and Richard Zigeuner and Libertino, {John A} and Evans, {Christopher P}",
note = "Copyright {\textcopyright} 2013 European Association of Urology. Published by Elsevier B.V. All rights reserved.",
year = "2014",
month = sep,
doi = "10.1016/j.eururo.2013.06.048",
language = "English",
volume = "66",
pages = "577--83",
journal = "EUR UROL",
issn = "0302-2838",
publisher = "Elsevier",
number = "3",

}

RIS

TY - JOUR

T1 - Impact of histologic subtype on cancer-specific survival in patients with renal cell carcinoma and tumor thrombus

AU - Tilki, Derya

AU - Nguyen, Hao G

AU - Dall'Era, Marc A

AU - Bertini, Roberto

AU - Carballido, Joaquín A

AU - Chromecki, Thomas

AU - Ciancio, Gaetano

AU - Daneshmand, Siamak

AU - Gontero, Paolo

AU - Gonzalez, Javier

AU - Haferkamp, Axel

AU - Hohenfellner, Markus

AU - Huang, William C

AU - Koppie, Theresa M

AU - Lorentz, C Adam

AU - Mandel, Philipp

AU - Martinez-Salamanca, Juan I

AU - Master, Viraj A

AU - Matloob, Rayan

AU - McKiernan, James M

AU - Mlynarczyk, Carrie M

AU - Montorsi, Francesco

AU - Novara, Giacomo

AU - Pahernik, Sascha

AU - Palou, Juan

AU - Pruthi, Raj S

AU - Ramaswamy, Krishna

AU - Rodriguez Faba, Oscar

AU - Russo, Paul

AU - Shariat, Shahrokh F

AU - Spahn, Martin

AU - Terrone, Carlo

AU - Vergho, Daniel

AU - Wallen, Eric M

AU - Xylinas, Evanguelos

AU - Zigeuner, Richard

AU - Libertino, John A

AU - Evans, Christopher P

N1 - Copyright © 2013 European Association of Urology. Published by Elsevier B.V. All rights reserved.

PY - 2014/9

Y1 - 2014/9

N2 - BACKGROUND: Although different prognostic factors for patients with renal cell carcinoma (RCC) and vena cava tumor thrombus (TT) have been studied, the prognostic value of histologic subtype in these patients remains unclear.OBJECTIVE: We analyzed the impact of histologic subtype on cancer-specific survival (CSS).DESIGN, SETTINGS, AND PARTICIPANTS: We retrospectively analyzed the records of 1774 patients with RCC and TT who underwent radical nephrectomy and tumor thrombectomy from 1971 to 2012 at 22 US and European centers.OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: Multivariable ordered logistic and Cox regression models were used to quantify the impact of tumor histology on CSS.RESULTS AND LIMITATIONS: Overall 5-yr CSS was 53.4% (confidence interval [CI], 50.5-56.2) in the entire group. TT level (according to the Mayo classification of macroscopic venous invasion in RCC) was I in 38.5% of patients, II in 30.6%, III in 17.3%, and IV in 13.5%. Histologic subtypes were clear cell renal cell carcinoma (cRCC) in 89.9% of patients, papillary renal cell carcinoma (pRCC) in 8.5%, and chromophobe RCC in 1.6%. In univariable analysis, pRCC was associated with a significantly worse CSS (p<0.001) compared with cRCC. In multivariable analysis, the presence of pRCC was independently associated with CSS (hazard ratio: 1.62; CI, 1.01-2.61; p<0.05). Higher TT level, positive lymph node status, distant metastasis, and fat invasion were also independently associated with CSS.CONCLUSIONS: In our multi-institutional series, we found that patients with pRCC and vena cava TT who underwent radical nephrectomy and tumor thrombectomy had significantly worse cancer-specific outcomes when compared with patients with other histologic subtypes of RCC. We confirmed that higher TT level and fat invasion were independently associated with reduced CSS.

AB - BACKGROUND: Although different prognostic factors for patients with renal cell carcinoma (RCC) and vena cava tumor thrombus (TT) have been studied, the prognostic value of histologic subtype in these patients remains unclear.OBJECTIVE: We analyzed the impact of histologic subtype on cancer-specific survival (CSS).DESIGN, SETTINGS, AND PARTICIPANTS: We retrospectively analyzed the records of 1774 patients with RCC and TT who underwent radical nephrectomy and tumor thrombectomy from 1971 to 2012 at 22 US and European centers.OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: Multivariable ordered logistic and Cox regression models were used to quantify the impact of tumor histology on CSS.RESULTS AND LIMITATIONS: Overall 5-yr CSS was 53.4% (confidence interval [CI], 50.5-56.2) in the entire group. TT level (according to the Mayo classification of macroscopic venous invasion in RCC) was I in 38.5% of patients, II in 30.6%, III in 17.3%, and IV in 13.5%. Histologic subtypes were clear cell renal cell carcinoma (cRCC) in 89.9% of patients, papillary renal cell carcinoma (pRCC) in 8.5%, and chromophobe RCC in 1.6%. In univariable analysis, pRCC was associated with a significantly worse CSS (p<0.001) compared with cRCC. In multivariable analysis, the presence of pRCC was independently associated with CSS (hazard ratio: 1.62; CI, 1.01-2.61; p<0.05). Higher TT level, positive lymph node status, distant metastasis, and fat invasion were also independently associated with CSS.CONCLUSIONS: In our multi-institutional series, we found that patients with pRCC and vena cava TT who underwent radical nephrectomy and tumor thrombectomy had significantly worse cancer-specific outcomes when compared with patients with other histologic subtypes of RCC. We confirmed that higher TT level and fat invasion were independently associated with reduced CSS.

KW - Adipose Tissue

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Carcinoma, Renal Cell

KW - Female

KW - Humans

KW - Kidney Neoplasms

KW - Lymphatic Metastasis

KW - Male

KW - Middle Aged

KW - Neoplasm Invasiveness

KW - Nephrectomy

KW - Prognosis

KW - Retrospective Studies

KW - Severity of Illness Index

KW - Survival Rate

KW - Venae Cavae

KW - Venous Thrombosis

KW - Young Adult

KW - Journal Article

U2 - 10.1016/j.eururo.2013.06.048

DO - 10.1016/j.eururo.2013.06.048

M3 - SCORING: Journal article

C2 - 23871402

VL - 66

SP - 577

EP - 583

JO - EUR UROL

JF - EUR UROL

SN - 0302-2838

IS - 3

ER -