Impact of gender and age on cardiovascular function late after repair of tetralogy of Fallot: percentiles based on cardiac magnetic resonance
Standard
Impact of gender and age on cardiovascular function late after repair of tetralogy of Fallot: percentiles based on cardiac magnetic resonance. / Sarikouch, Samir; Koerperich, Hermann; Dubowy, Karl-Otto; Boethig, Dietmar; Boettler, Petra; Mir, Thomas S; Peters, Brigitte; Kuehne, Titus; Beerbaum, Philipp; German Competence Network for Congenital Heart Defects Investigators.
In: CIRC-CARDIOVASC IMAG, Vol. 4, No. 6, 11.2011, p. 703-711.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Impact of gender and age on cardiovascular function late after repair of tetralogy of Fallot: percentiles based on cardiac magnetic resonance
AU - Sarikouch, Samir
AU - Koerperich, Hermann
AU - Dubowy, Karl-Otto
AU - Boethig, Dietmar
AU - Boettler, Petra
AU - Mir, Thomas S
AU - Peters, Brigitte
AU - Kuehne, Titus
AU - Beerbaum, Philipp
AU - German Competence Network for Congenital Heart Defects Investigators
PY - 2011/11
Y1 - 2011/11
N2 - BACKGROUND: The impact of gender and age on cardiac function by cardiac magnetic resonance (CMR) in repaired tetralogy of Fallot (TOF) is unknown, which limits the value of currently discussed volumetric thresholds and the accuracy of individual follow-up.METHODS AND RESULTS: In a nationwide, prospective, 14-center study, 407 consecutive patients with repaired TOF (age, 17.9±8.3 years; range, 8-59 years; 226 male patients) underwent standardized CMR ventricular volumetry and flow quantification (pulmonary artery/ascending aorta). There were no sex differences for age at TOF repair, type of repair, number of prior repair palliations or reinterventions after repair, pulmonary regurgitation fraction, and maximal gradient across the right ventricular outflow tract. Biventricular volumes and mass (indexed to body surface area), available in 380 of 407 patients, respectively, were higher in male patients (P<0.003), but biventricular ejection fraction was higher in female patients (P<0.012). As opposed to reported data of healthy populations, sex-specific reference percentiles computed for an age range of 8 to 40 years (lambda-mu-sigma method) demonstrated (1) an increase of end-diastolic and end-systolic left ventricular volumes, particularly in female patients; (2) an increase of end-systolic right ventricular volumes in both sexes; and (3) a decrease of biventricular ejection fraction in male patients, whereas in female patients, only right ventricular ejection fraction decreased.CONCLUSIONS: Significant gender differences of biventricular volumes, function, and mass by CMR exist late after repair of TOF, suggesting that age and gender cannot be ignored when discussing thresholds. Gender-specific percentiles may present a more relevant framework of reference for an individual patient at a given age and suggest a gradual decline of biventricular systolic function over time.
AB - BACKGROUND: The impact of gender and age on cardiac function by cardiac magnetic resonance (CMR) in repaired tetralogy of Fallot (TOF) is unknown, which limits the value of currently discussed volumetric thresholds and the accuracy of individual follow-up.METHODS AND RESULTS: In a nationwide, prospective, 14-center study, 407 consecutive patients with repaired TOF (age, 17.9±8.3 years; range, 8-59 years; 226 male patients) underwent standardized CMR ventricular volumetry and flow quantification (pulmonary artery/ascending aorta). There were no sex differences for age at TOF repair, type of repair, number of prior repair palliations or reinterventions after repair, pulmonary regurgitation fraction, and maximal gradient across the right ventricular outflow tract. Biventricular volumes and mass (indexed to body surface area), available in 380 of 407 patients, respectively, were higher in male patients (P<0.003), but biventricular ejection fraction was higher in female patients (P<0.012). As opposed to reported data of healthy populations, sex-specific reference percentiles computed for an age range of 8 to 40 years (lambda-mu-sigma method) demonstrated (1) an increase of end-diastolic and end-systolic left ventricular volumes, particularly in female patients; (2) an increase of end-systolic right ventricular volumes in both sexes; and (3) a decrease of biventricular ejection fraction in male patients, whereas in female patients, only right ventricular ejection fraction decreased.CONCLUSIONS: Significant gender differences of biventricular volumes, function, and mass by CMR exist late after repair of TOF, suggesting that age and gender cannot be ignored when discussing thresholds. Gender-specific percentiles may present a more relevant framework of reference for an individual patient at a given age and suggest a gradual decline of biventricular systolic function over time.
KW - Adolescent
KW - Adult
KW - Age Factors
KW - Cardiac Surgical Procedures/adverse effects
KW - Child
KW - Cohort Studies
KW - Disease Progression
KW - Female
KW - Follow-Up Studies
KW - Germany
KW - Heart Function Tests
KW - Humans
KW - Magnetic Resonance Imaging/methods
KW - Male
KW - Middle Aged
KW - Monitoring, Physiologic/methods
KW - Prospective Studies
KW - Risk Assessment
KW - Sex Factors
KW - Stroke Volume
KW - Survival Rate
KW - Tetralogy of Fallot/diagnosis
KW - Time Factors
KW - Ventricular Function, Left/physiology
KW - Ventricular Function, Right/physiology
KW - Young Adult
U2 - 10.1161/CIRCIMAGING.111.963637
DO - 10.1161/CIRCIMAGING.111.963637
M3 - SCORING: Journal article
C2 - 21908707
VL - 4
SP - 703
EP - 711
JO - CIRC-CARDIOVASC IMAG
JF - CIRC-CARDIOVASC IMAG
SN - 1941-9651
IS - 6
ER -
