Impact of clinical factors and surgical outcome on long-term survival in high-grade serous ovarian cancer: a multicenter analysis
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Impact of clinical factors and surgical outcome on long-term survival in high-grade serous ovarian cancer: a multicenter analysis. / Baum, Joanna; Braicu, Elena Ioana; Hunsicker, Oliver; Vergote, Ignace; Concin, Nicole; Van Nieuwenhuysen, Els; Feldheiser, Aarne; Achimas-Cadariu, Patriciu; Darb-Esfahani, Silvia; Berger, Astrid; Fetica, Bogdan; Mahner, Sven; Papadia, Andrea; Wölber, Linn; Gasparri, Maria Luisa; Vanderstichele, Adriaan; Benedetti Panici, Pierluigi; Mueller, Michael D; Ruscito, Ilary; Woopen, Hannah; Sehouli, Jalid.
In: INT J GYNECOL CANCER, Vol. 31, No. 5, 05.2021, p. 713-720.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Impact of clinical factors and surgical outcome on long-term survival in high-grade serous ovarian cancer: a multicenter analysis
AU - Baum, Joanna
AU - Braicu, Elena Ioana
AU - Hunsicker, Oliver
AU - Vergote, Ignace
AU - Concin, Nicole
AU - Van Nieuwenhuysen, Els
AU - Feldheiser, Aarne
AU - Achimas-Cadariu, Patriciu
AU - Darb-Esfahani, Silvia
AU - Berger, Astrid
AU - Fetica, Bogdan
AU - Mahner, Sven
AU - Papadia, Andrea
AU - Wölber, Linn
AU - Gasparri, Maria Luisa
AU - Vanderstichele, Adriaan
AU - Benedetti Panici, Pierluigi
AU - Mueller, Michael D
AU - Ruscito, Ilary
AU - Woopen, Hannah
AU - Sehouli, Jalid
N1 - © IGCS and ESGO 2021. No commercial re-use. See rights and permissions. Published by BMJ.
PY - 2021/5
Y1 - 2021/5
N2 - INTRODUCTION: Long-term survivors of ovarian cancer are a unique group of patients in whom prognostic factors for long-term survival have been poorly described. Such factors may provide information for a more personalized therapeutic approach. The objective of this study is to determine further characteristics of long-term survivors with high-grade serous ovarian cancer.METHODS: Long-term survivors were defined as patients living longer than 8 years after first diagnosis and were recruited within seven high volume centers across Europe from November 1988 to November 2008. The control group included patients with high-grade serous ovarian cancer with less than 5 years' survival identified from the systematic 'Tumorbank ovarian cancer' database. A subanalysis of Charité patients only was performed separately for in-depth analysis of tumor dissemination. Propensity score matching with nearest-neighbor caliper width was used to match long-term survivors and the control group regarding age, FIGO stage, and residual tumor.RESULTS: A total of 276 patients with high-grade serous ovarian cancer were included, divided into 131 long-term survivors and 145 control group patients. After propensity score matching and multivariable adjustment, platinum sensitivity (p=0.002) was an independent favorable prognostic factor whereas recurrence (p<0.001) and ascites (p=0.021) were independent detrimental predictors for long-term survival. Significantly more long-term survivors tested positive for mutation in the BRCA1 gene than the BRCA2 gene (p=0.016). Intraoperatively, these patients had less tumor involvement of the upper abdomen at initial surgery (p=0.024). Complexity of surgery and surgical techniques were similar in both cohorts.CONCLUSION: Platinum sensitivity constitutes a favorable factor for long-term survival whereas tumor involvement of the upper abdomen, ascites, and recurrence have a negative impact. Based on clinical estimation, long-term survival is associated with combinations of clinical, surgical, and molecular factors.
AB - INTRODUCTION: Long-term survivors of ovarian cancer are a unique group of patients in whom prognostic factors for long-term survival have been poorly described. Such factors may provide information for a more personalized therapeutic approach. The objective of this study is to determine further characteristics of long-term survivors with high-grade serous ovarian cancer.METHODS: Long-term survivors were defined as patients living longer than 8 years after first diagnosis and were recruited within seven high volume centers across Europe from November 1988 to November 2008. The control group included patients with high-grade serous ovarian cancer with less than 5 years' survival identified from the systematic 'Tumorbank ovarian cancer' database. A subanalysis of Charité patients only was performed separately for in-depth analysis of tumor dissemination. Propensity score matching with nearest-neighbor caliper width was used to match long-term survivors and the control group regarding age, FIGO stage, and residual tumor.RESULTS: A total of 276 patients with high-grade serous ovarian cancer were included, divided into 131 long-term survivors and 145 control group patients. After propensity score matching and multivariable adjustment, platinum sensitivity (p=0.002) was an independent favorable prognostic factor whereas recurrence (p<0.001) and ascites (p=0.021) were independent detrimental predictors for long-term survival. Significantly more long-term survivors tested positive for mutation in the BRCA1 gene than the BRCA2 gene (p=0.016). Intraoperatively, these patients had less tumor involvement of the upper abdomen at initial surgery (p=0.024). Complexity of surgery and surgical techniques were similar in both cohorts.CONCLUSION: Platinum sensitivity constitutes a favorable factor for long-term survival whereas tumor involvement of the upper abdomen, ascites, and recurrence have a negative impact. Based on clinical estimation, long-term survival is associated with combinations of clinical, surgical, and molecular factors.
U2 - 10.1136/ijgc-2020-002023
DO - 10.1136/ijgc-2020-002023
M3 - SCORING: Journal article
C2 - 33563640
VL - 31
SP - 713
EP - 720
JO - INT J GYNECOL CANCER
JF - INT J GYNECOL CANCER
SN - 1048-891X
IS - 5
ER -
