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Impact of CCR7 on T-Cell Response and Susceptibility to Yersinia pseudotuberculosis Infection

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Impact of CCR7 on T-Cell Response and Susceptibility to Yersinia pseudotuberculosis Infection. / Pezoldt, Joern; Pisano, Fabio; Heine, Wiebke; Pasztoi, Maria; Rosenheinrich, Maik; Nuss, Aaron M; Pils, Marina C; Prinz, Immo; Förster, Reinhold; Huehn, Jochen; Dersch, Petra.

In: J INFECT DIS, Vol. 216, No. 6, 15.09.2017, p. 752-760.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Pezoldt, J, Pisano, F, Heine, W, Pasztoi, M, Rosenheinrich, M, Nuss, AM, Pils, MC, Prinz, I, Förster, R, Huehn, J & Dersch, P 2017, 'Impact of CCR7 on T-Cell Response and Susceptibility to Yersinia pseudotuberculosis Infection', J INFECT DIS, vol. 216, no. 6, pp. 752-760. https://doi.org/10.1093/infdis/jix037

APA

Pezoldt, J., Pisano, F., Heine, W., Pasztoi, M., Rosenheinrich, M., Nuss, A. M., Pils, M. C., Prinz, I., Förster, R., Huehn, J., & Dersch, P. (2017). Impact of CCR7 on T-Cell Response and Susceptibility to Yersinia pseudotuberculosis Infection. J INFECT DIS, 216(6), 752-760. https://doi.org/10.1093/infdis/jix037

Vancouver

Pezoldt J, Pisano F, Heine W, Pasztoi M, Rosenheinrich M, Nuss AM et al. Impact of CCR7 on T-Cell Response and Susceptibility to Yersinia pseudotuberculosis Infection. J INFECT DIS. 2017 Sep 15;216(6):752-760. https://doi.org/10.1093/infdis/jix037

Bibtex

@article{f1f79db6508e4c1fad29714a6a8860e2,
title = "Impact of CCR7 on T-Cell Response and Susceptibility to Yersinia pseudotuberculosis Infection",
abstract = "Background: To successfully limit pathogen dissemination, an immunological link between the entry tissue of the pathogen and the underlying secondary lymphoid organs (SLOs) needs to be established to prime adaptive immune responses. Here, the prerequisite of CCR7 to mount host immune responses within SLOs during gastrointestinal Yersinia pseudotuberculosis infection to limit pathogen spread was investigated.Methods: Survival, bacterial dissemination, and intestinal and systemic pathology of wild-type and CCR7-/- mice were assessed and correlated to the presence of immune cell subsets and cytokine responses throughout the course of infection.Results: The CCR7-/- mice show a significantly higher morbidity and are more prone to pathogen dissemination and intestinal and systemic inflammation during the oral route of infection. Significant impact of CCR7 deficiency over the course of infection on several immunological parameters were observed (ie, elevated neutrophil-dominated innate immune response in Peyer's patches, limited dendritic cell migration to mesenteric lymph nodes [mLNs] causing reduced T cell-mediated adaptive immune responses (in particular Th17-like responses) in mLNs).Conclusions: Our work indicates that CCR7 is required to mount a robust immune response against enteropathogenic Y. pseudotuberculosis by promoting Th17-like responses in mLNs.",
keywords = "Animals, Cell Movement, Dendritic Cells/immunology, Genetic Predisposition to Disease, Host-Pathogen Interactions/genetics, Intestines/immunology, Lymph Nodes/immunology, Mice, Myeloid Cells/immunology, Peyer's Patches/immunology, Receptors, CCR7/genetics, Th17 Cells/immunology, Yersinia pseudotuberculosis, Yersinia pseudotuberculosis Infections/genetics",
author = "Joern Pezoldt and Fabio Pisano and Wiebke Heine and Maria Pasztoi and Maik Rosenheinrich and Nuss, {Aaron M} and Pils, {Marina C} and Immo Prinz and Reinhold F{\"o}rster and Jochen Huehn and Petra Dersch",
note = "{\textcopyright} The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissions@oup.com.",
year = "2017",
month = sep,
day = "15",
doi = "10.1093/infdis/jix037",
language = "English",
volume = "216",
pages = "752--760",
journal = "J INFECT DIS",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "6",

}

RIS

TY - JOUR

T1 - Impact of CCR7 on T-Cell Response and Susceptibility to Yersinia pseudotuberculosis Infection

AU - Pezoldt, Joern

AU - Pisano, Fabio

AU - Heine, Wiebke

AU - Pasztoi, Maria

AU - Rosenheinrich, Maik

AU - Nuss, Aaron M

AU - Pils, Marina C

AU - Prinz, Immo

AU - Förster, Reinhold

AU - Huehn, Jochen

AU - Dersch, Petra

N1 - © The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissions@oup.com.

PY - 2017/9/15

Y1 - 2017/9/15

N2 - Background: To successfully limit pathogen dissemination, an immunological link between the entry tissue of the pathogen and the underlying secondary lymphoid organs (SLOs) needs to be established to prime adaptive immune responses. Here, the prerequisite of CCR7 to mount host immune responses within SLOs during gastrointestinal Yersinia pseudotuberculosis infection to limit pathogen spread was investigated.Methods: Survival, bacterial dissemination, and intestinal and systemic pathology of wild-type and CCR7-/- mice were assessed and correlated to the presence of immune cell subsets and cytokine responses throughout the course of infection.Results: The CCR7-/- mice show a significantly higher morbidity and are more prone to pathogen dissemination and intestinal and systemic inflammation during the oral route of infection. Significant impact of CCR7 deficiency over the course of infection on several immunological parameters were observed (ie, elevated neutrophil-dominated innate immune response in Peyer's patches, limited dendritic cell migration to mesenteric lymph nodes [mLNs] causing reduced T cell-mediated adaptive immune responses (in particular Th17-like responses) in mLNs).Conclusions: Our work indicates that CCR7 is required to mount a robust immune response against enteropathogenic Y. pseudotuberculosis by promoting Th17-like responses in mLNs.

AB - Background: To successfully limit pathogen dissemination, an immunological link between the entry tissue of the pathogen and the underlying secondary lymphoid organs (SLOs) needs to be established to prime adaptive immune responses. Here, the prerequisite of CCR7 to mount host immune responses within SLOs during gastrointestinal Yersinia pseudotuberculosis infection to limit pathogen spread was investigated.Methods: Survival, bacterial dissemination, and intestinal and systemic pathology of wild-type and CCR7-/- mice were assessed and correlated to the presence of immune cell subsets and cytokine responses throughout the course of infection.Results: The CCR7-/- mice show a significantly higher morbidity and are more prone to pathogen dissemination and intestinal and systemic inflammation during the oral route of infection. Significant impact of CCR7 deficiency over the course of infection on several immunological parameters were observed (ie, elevated neutrophil-dominated innate immune response in Peyer's patches, limited dendritic cell migration to mesenteric lymph nodes [mLNs] causing reduced T cell-mediated adaptive immune responses (in particular Th17-like responses) in mLNs).Conclusions: Our work indicates that CCR7 is required to mount a robust immune response against enteropathogenic Y. pseudotuberculosis by promoting Th17-like responses in mLNs.

KW - Animals

KW - Cell Movement

KW - Dendritic Cells/immunology

KW - Genetic Predisposition to Disease

KW - Host-Pathogen Interactions/genetics

KW - Intestines/immunology

KW - Lymph Nodes/immunology

KW - Mice

KW - Myeloid Cells/immunology

KW - Peyer's Patches/immunology

KW - Receptors, CCR7/genetics

KW - Th17 Cells/immunology

KW - Yersinia pseudotuberculosis

KW - Yersinia pseudotuberculosis Infections/genetics

U2 - 10.1093/infdis/jix037

DO - 10.1093/infdis/jix037

M3 - SCORING: Journal article

C2 - 28329174

VL - 216

SP - 752

EP - 760

JO - J INFECT DIS

JF - J INFECT DIS

SN - 0022-1899

IS - 6

ER -