Research ExplorerPublicationsImpact of atrial fibrillation pattern on outcomes after left...

Impact of atrial fibrillation pattern on outcomes after left atrial appendage closure: lessons from the prospective LAARGE registry

Standard

Impact of atrial fibrillation pattern on outcomes after left atrial appendage closure: lessons from the prospective LAARGE registry. / Kany, Shinwan; Brachmann, Johannes; Lewalter, Thorsten; Akin, Ibrahim; Sievert, Horst; Zeymer, Uwe; Ledwoch, Jakob; Ince, Hüseyin; Thomas, Dierk; Hochadel, Matthias; Senges, Jochen; Kirchhof, Paulus; Rillig, Andreas.

In: CLIN RES CARDIOL, Vol. 111, No. 5, 05.2022, p. 511-521.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Kany, S, Brachmann, J, Lewalter, T, Akin, I, Sievert, H, Zeymer, U, Ledwoch, J, Ince, H, Thomas, D, Hochadel, M, Senges, J, Kirchhof, P & Rillig, A 2022, 'Impact of atrial fibrillation pattern on outcomes after left atrial appendage closure: lessons from the prospective LAARGE registry', CLIN RES CARDIOL, vol. 111, no. 5, pp. 511-521. https://doi.org/10.1007/s00392-021-01874-3

APA

Kany, S., Brachmann, J., Lewalter, T., Akin, I., Sievert, H., Zeymer, U., Ledwoch, J., Ince, H., Thomas, D., Hochadel, M., Senges, J., Kirchhof, P., & Rillig, A. (2022). Impact of atrial fibrillation pattern on outcomes after left atrial appendage closure: lessons from the prospective LAARGE registry. CLIN RES CARDIOL, 111(5), 511-521. https://doi.org/10.1007/s00392-021-01874-3

Vancouver

Kany S, Brachmann J, Lewalter T, Akin I, Sievert H, Zeymer U et al. Impact of atrial fibrillation pattern on outcomes after left atrial appendage closure: lessons from the prospective LAARGE registry. CLIN RES CARDIOL. 2022 May;111(5):511-521. https://doi.org/10.1007/s00392-021-01874-3

Bibtex

@article{7b94353ca9da44e6ae91880d151373a2,
title = "Impact of atrial fibrillation pattern on outcomes after left atrial appendage closure: lessons from the prospective LAARGE registry",
abstract = "BACKGROUND: Non-paroxysmal (NPAF) forms of atrial fibrillation (AF) have been reported to be associated with an increased risk for systemic embolism or death.METHODS: Comparison of procedural details and long-term outcomes in patients (pts) with paroxysmal AF (PAF) against controls with NPAF in the prospective, multicentre observational registry of patients undergoing LAAC (LAARGE).RESULTS: A total of 638 pts (PAF 274 pts, NPAF 364 pts) were enrolled. In both groups, a history of PVI was rare (4.0% vs 1.6%, p = 0.066). The total CHA2DS2-VASc score was lower in the PAF group (4.4 ± 1.5 vs 4.6 ± 1.5, p = 0.033), while HAS-BLED score (3.8 ± 1.1 vs 3.9 ± 1.1, p = 0.40) was comparable. The rate of successful implantation was equally high (97.4% vs 97.8%, p = 0.77). In the three-month echo follow-up, LA thrombi (2.1% vs 7.3%, p = 0.12) and peridevice leak > 5 mm (0.0% vs 7.1%, p = 0.53) were numerically higher in the NPAF group. Overall, in-hospital complications occurred in 15.0% of the PAF cohort and 10.7% of the NPAF cohort (p = 0.12). In the one-year follow-up, unadjusted mortality (8.4% vs 14.0%, p = 0.039) and combined outcome of death, stroke and systemic embolism (8.8% vs 15.1%, p = 0.022) were significantly higher in the NPAF cohort. After adjusting for CHA2DS2-VASc and previous bleeding, NPAF was associated with increased death/stroke/systemic embolism (HR 1.67, 95% CI 1.02-2.72, p = 0.041).CONCLUSION: Atrial fibrillation type did not impair periprocedural safety or in-hospital MACE patients undergoing LAAC. However, after one year, NPAF was associated with higher mortality.",
author = "Shinwan Kany and Johannes Brachmann and Thorsten Lewalter and Ibrahim Akin and Horst Sievert and Uwe Zeymer and Jakob Ledwoch and H{\"u}seyin Ince and Dierk Thomas and Matthias Hochadel and Jochen Senges and Paulus Kirchhof and Andreas Rillig",
year = "2022",
month = may,
doi = "10.1007/s00392-021-01874-3",
language = "English",
volume = "111",
pages = "511--521",
journal = "CLIN RES CARDIOL",
issn = "1861-0684",
publisher = "D. Steinkopff-Verlag",
number = "5",

}

RIS

TY - JOUR

T1 - Impact of atrial fibrillation pattern on outcomes after left atrial appendage closure: lessons from the prospective LAARGE registry

AU - Kany, Shinwan

AU - Brachmann, Johannes

AU - Lewalter, Thorsten

AU - Akin, Ibrahim

AU - Sievert, Horst

AU - Zeymer, Uwe

AU - Ledwoch, Jakob

AU - Ince, Hüseyin

AU - Thomas, Dierk

AU - Hochadel, Matthias

AU - Senges, Jochen

AU - Kirchhof, Paulus

AU - Rillig, Andreas

PY - 2022/5

Y1 - 2022/5

N2 - BACKGROUND: Non-paroxysmal (NPAF) forms of atrial fibrillation (AF) have been reported to be associated with an increased risk for systemic embolism or death.METHODS: Comparison of procedural details and long-term outcomes in patients (pts) with paroxysmal AF (PAF) against controls with NPAF in the prospective, multicentre observational registry of patients undergoing LAAC (LAARGE).RESULTS: A total of 638 pts (PAF 274 pts, NPAF 364 pts) were enrolled. In both groups, a history of PVI was rare (4.0% vs 1.6%, p = 0.066). The total CHA2DS2-VASc score was lower in the PAF group (4.4 ± 1.5 vs 4.6 ± 1.5, p = 0.033), while HAS-BLED score (3.8 ± 1.1 vs 3.9 ± 1.1, p = 0.40) was comparable. The rate of successful implantation was equally high (97.4% vs 97.8%, p = 0.77). In the three-month echo follow-up, LA thrombi (2.1% vs 7.3%, p = 0.12) and peridevice leak > 5 mm (0.0% vs 7.1%, p = 0.53) were numerically higher in the NPAF group. Overall, in-hospital complications occurred in 15.0% of the PAF cohort and 10.7% of the NPAF cohort (p = 0.12). In the one-year follow-up, unadjusted mortality (8.4% vs 14.0%, p = 0.039) and combined outcome of death, stroke and systemic embolism (8.8% vs 15.1%, p = 0.022) were significantly higher in the NPAF cohort. After adjusting for CHA2DS2-VASc and previous bleeding, NPAF was associated with increased death/stroke/systemic embolism (HR 1.67, 95% CI 1.02-2.72, p = 0.041).CONCLUSION: Atrial fibrillation type did not impair periprocedural safety or in-hospital MACE patients undergoing LAAC. However, after one year, NPAF was associated with higher mortality.

AB - BACKGROUND: Non-paroxysmal (NPAF) forms of atrial fibrillation (AF) have been reported to be associated with an increased risk for systemic embolism or death.METHODS: Comparison of procedural details and long-term outcomes in patients (pts) with paroxysmal AF (PAF) against controls with NPAF in the prospective, multicentre observational registry of patients undergoing LAAC (LAARGE).RESULTS: A total of 638 pts (PAF 274 pts, NPAF 364 pts) were enrolled. In both groups, a history of PVI was rare (4.0% vs 1.6%, p = 0.066). The total CHA2DS2-VASc score was lower in the PAF group (4.4 ± 1.5 vs 4.6 ± 1.5, p = 0.033), while HAS-BLED score (3.8 ± 1.1 vs 3.9 ± 1.1, p = 0.40) was comparable. The rate of successful implantation was equally high (97.4% vs 97.8%, p = 0.77). In the three-month echo follow-up, LA thrombi (2.1% vs 7.3%, p = 0.12) and peridevice leak > 5 mm (0.0% vs 7.1%, p = 0.53) were numerically higher in the NPAF group. Overall, in-hospital complications occurred in 15.0% of the PAF cohort and 10.7% of the NPAF cohort (p = 0.12). In the one-year follow-up, unadjusted mortality (8.4% vs 14.0%, p = 0.039) and combined outcome of death, stroke and systemic embolism (8.8% vs 15.1%, p = 0.022) were significantly higher in the NPAF cohort. After adjusting for CHA2DS2-VASc and previous bleeding, NPAF was associated with increased death/stroke/systemic embolism (HR 1.67, 95% CI 1.02-2.72, p = 0.041).CONCLUSION: Atrial fibrillation type did not impair periprocedural safety or in-hospital MACE patients undergoing LAAC. However, after one year, NPAF was associated with higher mortality.

U2 - 10.1007/s00392-021-01874-3

DO - 10.1007/s00392-021-01874-3

M3 - SCORING: Journal article

C2 - 34043052

VL - 111

SP - 511

EP - 521

JO - CLIN RES CARDIOL

JF - CLIN RES CARDIOL

SN - 1861-0684

IS - 5

ER -