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Impact of a time-to-effect-guided ablation protocol in cryoballoon ablation on the durability of pulmonary vein isolation

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Impact of a time-to-effect-guided ablation protocol in cryoballoon ablation on the durability of pulmonary vein isolation. / Rexha, Enida; Heeger, Christian-Hendrik; Maack, Sabrina; Rottner, Laura; Wohlmuth, Peter; Lemes, Christine; Maurer, Tilman; Reißmann, Bruno; Rillig, Andreas; Mathew, Shibu; Sohns, Christian; Ouyang, Feifan; Kuck, Karl-Heinz; Metzner, Andreas.

In: J CARDIOVASC ELECTR, Vol. 33, No. 6, 06.2022, p. 1096-1103.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Rexha, E, Heeger, C-H, Maack, S, Rottner, L, Wohlmuth, P, Lemes, C, Maurer, T, Reißmann, B, Rillig, A, Mathew, S, Sohns, C, Ouyang, F, Kuck, K-H & Metzner, A 2022, 'Impact of a time-to-effect-guided ablation protocol in cryoballoon ablation on the durability of pulmonary vein isolation', J CARDIOVASC ELECTR, vol. 33, no. 6, pp. 1096-1103. https://doi.org/10.1111/jce.15453

APA

Rexha, E., Heeger, C-H., Maack, S., Rottner, L., Wohlmuth, P., Lemes, C., Maurer, T., Reißmann, B., Rillig, A., Mathew, S., Sohns, C., Ouyang, F., Kuck, K-H., & Metzner, A. (2022). Impact of a time-to-effect-guided ablation protocol in cryoballoon ablation on the durability of pulmonary vein isolation. J CARDIOVASC ELECTR, 33(6), 1096-1103. https://doi.org/10.1111/jce.15453

Vancouver

Rexha E, Heeger C-H, Maack S, Rottner L, Wohlmuth P, Lemes C et al. Impact of a time-to-effect-guided ablation protocol in cryoballoon ablation on the durability of pulmonary vein isolation. J CARDIOVASC ELECTR. 2022 Jun;33(6):1096-1103. https://doi.org/10.1111/jce.15453

Bibtex

@article{73471f6abc114889b3fd955bd1cef325,
title = "Impact of a time-to-effect-guided ablation protocol in cryoballoon ablation on the durability of pulmonary vein isolation",
abstract = "BACKGROUND: Cryoballoon (CB)-based pulmonary vein isolation (PVI) has proven to be as effective as radiofrequency-based ablation. Different ablation protocols took the individual time-to-isolation (TTI) into account aiming at shorter but equally or even more effective freeze cycles. The current study sought to assess the impact of the TTI on PVI durability in patients undergoing a repeat procedure for recurrence of atrial tachyarrhythmia (ATA).METHODS AND RESULTS: In 205 patients with ATA recurrence after previous CB-based PVI, a total of 806 pulmonary veins (PVs) were identified. A total of 126 out of 806 PVs (16%) were previously treated with a TTI-guided ablation (Protocol #1; TTI + 120 s), in 92/806 (11%) PVs TTI was only monitored (m) but fixed freeze cycles were applied (Protocol #2; mTTI) and in 588/806 (73%) a fixed freeze cycle was applied without mTTI. There was no difference in the PV-reconduction rate between the groups (p = .23). The right inferior pulmonary vein (RIPV) showed overall significantly higher reconduction rates compared to the other PVs (RIPV-left inferior PV p < .003, -left superior PV p < .001, -right superior PV p < .013). Twenty-one patients (10%) were demonstrated to have only electrical reconduction of the RIPV, while all other PVs were still electrically isolated.CONCLUSIONS: The TTI-based CB ablation protocol did not show significant differences regarding PV-reconduction rates compared to the other ablation protocols.",
keywords = "Atrial Fibrillation/diagnosis, Catheter Ablation/adverse effects, Cryosurgery/adverse effects, Humans, Pulmonary Veins/surgery, Recurrence, Treatment Outcome",
author = "Enida Rexha and Christian-Hendrik Heeger and Sabrina Maack and Laura Rottner and Peter Wohlmuth and Christine Lemes and Tilman Maurer and Bruno Rei{\ss}mann and Andreas Rillig and Shibu Mathew and Christian Sohns and Feifan Ouyang and Karl-Heinz Kuck and Andreas Metzner",
note = "{\textcopyright} 2022 Wiley Periodicals LLC.",
year = "2022",
month = jun,
doi = "10.1111/jce.15453",
language = "English",
volume = "33",
pages = "1096--1103",
journal = "J CARDIOVASC ELECTR",
issn = "1045-3873",
publisher = "Wiley-Blackwell",
number = "6",

}

RIS

TY - JOUR

T1 - Impact of a time-to-effect-guided ablation protocol in cryoballoon ablation on the durability of pulmonary vein isolation

AU - Rexha, Enida

AU - Heeger, Christian-Hendrik

AU - Maack, Sabrina

AU - Rottner, Laura

AU - Wohlmuth, Peter

AU - Lemes, Christine

AU - Maurer, Tilman

AU - Reißmann, Bruno

AU - Rillig, Andreas

AU - Mathew, Shibu

AU - Sohns, Christian

AU - Ouyang, Feifan

AU - Kuck, Karl-Heinz

AU - Metzner, Andreas

N1 - © 2022 Wiley Periodicals LLC.

PY - 2022/6

Y1 - 2022/6

N2 - BACKGROUND: Cryoballoon (CB)-based pulmonary vein isolation (PVI) has proven to be as effective as radiofrequency-based ablation. Different ablation protocols took the individual time-to-isolation (TTI) into account aiming at shorter but equally or even more effective freeze cycles. The current study sought to assess the impact of the TTI on PVI durability in patients undergoing a repeat procedure for recurrence of atrial tachyarrhythmia (ATA).METHODS AND RESULTS: In 205 patients with ATA recurrence after previous CB-based PVI, a total of 806 pulmonary veins (PVs) were identified. A total of 126 out of 806 PVs (16%) were previously treated with a TTI-guided ablation (Protocol #1; TTI + 120 s), in 92/806 (11%) PVs TTI was only monitored (m) but fixed freeze cycles were applied (Protocol #2; mTTI) and in 588/806 (73%) a fixed freeze cycle was applied without mTTI. There was no difference in the PV-reconduction rate between the groups (p = .23). The right inferior pulmonary vein (RIPV) showed overall significantly higher reconduction rates compared to the other PVs (RIPV-left inferior PV p < .003, -left superior PV p < .001, -right superior PV p < .013). Twenty-one patients (10%) were demonstrated to have only electrical reconduction of the RIPV, while all other PVs were still electrically isolated.CONCLUSIONS: The TTI-based CB ablation protocol did not show significant differences regarding PV-reconduction rates compared to the other ablation protocols.

AB - BACKGROUND: Cryoballoon (CB)-based pulmonary vein isolation (PVI) has proven to be as effective as radiofrequency-based ablation. Different ablation protocols took the individual time-to-isolation (TTI) into account aiming at shorter but equally or even more effective freeze cycles. The current study sought to assess the impact of the TTI on PVI durability in patients undergoing a repeat procedure for recurrence of atrial tachyarrhythmia (ATA).METHODS AND RESULTS: In 205 patients with ATA recurrence after previous CB-based PVI, a total of 806 pulmonary veins (PVs) were identified. A total of 126 out of 806 PVs (16%) were previously treated with a TTI-guided ablation (Protocol #1; TTI + 120 s), in 92/806 (11%) PVs TTI was only monitored (m) but fixed freeze cycles were applied (Protocol #2; mTTI) and in 588/806 (73%) a fixed freeze cycle was applied without mTTI. There was no difference in the PV-reconduction rate between the groups (p = .23). The right inferior pulmonary vein (RIPV) showed overall significantly higher reconduction rates compared to the other PVs (RIPV-left inferior PV p < .003, -left superior PV p < .001, -right superior PV p < .013). Twenty-one patients (10%) were demonstrated to have only electrical reconduction of the RIPV, while all other PVs were still electrically isolated.CONCLUSIONS: The TTI-based CB ablation protocol did not show significant differences regarding PV-reconduction rates compared to the other ablation protocols.

KW - Atrial Fibrillation/diagnosis

KW - Catheter Ablation/adverse effects

KW - Cryosurgery/adverse effects

KW - Humans

KW - Pulmonary Veins/surgery

KW - Recurrence

KW - Treatment Outcome

U2 - 10.1111/jce.15453

DO - 10.1111/jce.15453

M3 - SCORING: Journal article

C2 - 35304790

VL - 33

SP - 1096

EP - 1103

JO - J CARDIOVASC ELECTR

JF - J CARDIOVASC ELECTR

SN - 1045-3873

IS - 6

ER -